HERSHEY, Pa. -- A history of binge eating -- consuming large amounts of food in a short period of time -- may make an individual more likely to show other addiction-like behaviors, including substance abuse, according to Penn State College of Medicine researchers. In the short term, this finding may shed light on the factors that promote substance abuse, addiction, and relapse. In the long term, may help clinicians treat individuals suffering from this devastating disease.
- Environmental Sciences - Oct 30 Does it help conservation to put a price on nature?
- Medicine - Oct 30 European salamanders and newts vulnerable to fungal disease from Asia
- Business - Oct 30 Bringing space research closer to home: a roundup from Imperial’s SpaceLab 2014
- Business - Oct 30 Q&A with U-M Ford School dean: Economy and midterm election campaigns
- Medicine - Oct 30 Edie & Lew Wasserman Building opens in Stein Plaza at UCLA
- Environmental Sciences - Oct 30 They know the drill: UW leads the league in boring through ice sheets
- Physics - Oct 30 Lord of the Microrings
- Social Sciences - Oct 30 From pro- anorexia sites: 'dangerous stigma escalation'
- Medicine - Oct 30 Newly found fungus is threat to salamanders worldwide
- Medicine - Oct 30 Treating Ebola patients in Liberia: A Stanford physician’s story
- Social Sciences - Oct 30 Halloween reflects re-enchantment with the world, Stanford anthropologist says
- History - Oct 30 Major new history project will investigate the 'Tudors of Central Europe'
- Arts - Oct 30 Cornell plaster casts: 'embraced, defaced and dethroned'
- Life Sciences - Oct 30 Penn Medicine: Study Identifies Potential Treatment Target for Cocaine Addiction
- Life Sciences - Oct 30 U of M seeks public input on aquatic invasive species research
- Medicine - Oct 30 The Coming of Age of Stem Cell Therapy
Binge eating may lead to addiction-like behaviors
"Drug addiction persists as a major problem in the United States," said Patricia Sue Grigson, Ph.D., professor, Department of Neural and Behavioral Sciences. "Likewise, excessive food intake, like binge eating, has become problematic. Substance-abuse and binge eating are both characterized by a loss of control over consumption. Given the common characteristics of these two types of disorders, it is not surprising that the co-occurrence of eating disorders and substance abuse disorders is high. It is unknown, however, whether loss of control in one disorder predisposes an individual to loss of control in another."
Grigson and her colleagues found a link between bingeing on fat and the development of cocaine-seeking and -taking behaviors in rats, suggesting that conditions promoting excessive behavior toward one substance can increase the probability of excessive behavior toward another. They report their results in Behavioral Neuroscience.
The researchers used rats to test whether a history of binge eating on fat would augment addiction-like behavior toward cocaine by giving four groups of rats four different diets: normal rat chow; continuous ad lib access to an optional source of dietary fat; one hour of access to optional dietary fat daily; and one hour of access to dietary fat on Mondays, Wednesdays, and Fridays. All four groups also had unrestricted access to nutritionally complete chow and water. The researchers then assessed the cocaine-seeking and -taking behaviors.
"Fat bingeing behaviors developed in the rats with access to dietary fat on Mondays, Wednesdays, and Fridays -- the group with the most restricted access to the optional fat," Grigson said.
This group tended to take more cocaine late in training, continued to try to get cocaine when signaled it was not available, and worked harder for cocaine as work requirements increased.
"While the underlying mechanisms are not known, one point is clear from behavioral data: A history of bingeing on fat changed the brain, physiology, or both in a manner that made these rats more likely to seek and take a drug when tested more than a month later," Grigson said. "We must identify these predisposing neurophysiological changes."
While the consumption of fat in and of itself did not increase the likelihood of subsequent addiction-like behavior for cocaine, the irregular binge-type manner in which the fat was eaten proved critical. Rats that had continuous access to fat consumed more fat than any other group, but were three times less likely to exhibit addiction-like behavior for cocaine than the group with access only on Mondays, Wednesdays and Fridays.
"Indeed, while about 20 percent of those rats and humans exposed to cocaine will develop addiction-like behavior for the drug under normal circumstances, in our study, the probability of addiction to cocaine increased to approximately 50 (percent) for subjects with a history of having binged on fat," Grigson said.
Future studies will look more closely at how bingeing can lead to addiction-like behaviors -- whether bingeing on sugar or a mixture of sugar and fat also promotes cocaine or heroin addiction, for example, and whether bingeing on a drug, in turn, increases the likelihood of bingeing on fat.
Other researchers are Matthew D. Puhl, Angie M. Cason, Department of Neural and Behavioral Sciences, Penn State College of Medicine; Rebecca L. Corwin and Francis H.E. Wojnicki, Department of Nutritional Sciences, Penn State.
The National Institute on Drug Abuse funded this research.
Last job offers
- Social Sciences - 29.10
Professorship in Sociology or Anthropology of Tourism
- Mechanical Engineering - 29.10
Dozentin / Dozent Mechanik, Festigkeitslehre und Werkstofftechnik
- Mechanical Engineering - 29.10
Professorin / Professor Produktionstechnik und Automation
- Business - 28.10
Associate Professor at the GSEM (50%) and HES Professor at the HEG (50%) in Applied Economics
- Life Sciences - 27.10
Dozent/in Mess- und Automatisierungstechnik
- Business - 23.10
Wissenschaftlicher Referent für Wirtschaftspolitikberatung (m/w)
- Physics - 30.10
Professor of Cosmoparticle physics
- Administration - 29.10
Professor II /førsteamanuensis delstilling innen anvendt atomskalamodellering
- Business - 19.9
UniversitätsprofessorIn für die Stiftungsprofessur "Industrielle Energiesysteme"
- Social Sciences - 4.9
Juniorprofessur für Ethnologie mit Schwerpunkt, Politische Anthropologie (mit tenure track)
- Earth Sciences - 30.10
- Computer Science - 30.10
- Physics - 29.10
Lecturer (Assistant Professor)/Senior Lecturer (Associate Professor) in Physical Education
- Microtechnics - 27.10
Professor of Electronics and Systems Engineering
- Arts - 30.10
Assistant Professor - Painting / Drawing
- Mathematics - 30.10
Clinical Assistant / Associate Professor - Mathematics, Statistics, and Computer Science