- Life Sciences - 13:00 Old Hope for burns victims as researchers pilot revolutionary new dressing
- Medicine - 12:00 Palliative care expert informs new Quality of Death Index
- Life Sciences - 11:00 Birth weight and poor growth linked to later hearing and vision problems
- Life Sciences - 10:01 Piercing teeth in vertebrates didn’t evolve from their scales
- Life Sciences - 10:00 Hope for burns victims as researchers pilot revolutionary new dressing
- Medicine - 07:01 Department of Defense funds Australian research into inflammatory bowel disease
- Pedagogy - 06:01 Apps can benefit pre- schoolers, but parents need to choose wisely
- Environmental Sciences - Oct 6 MIT- USAID program releases evaluation of water filters
- Medicine - Oct 6 Predicting change in the Alzheimer’s brain
- Business - Oct 5 Imperial and MIT launch joint ’risky’ research fund
- Life Sciences - Oct 5 Chelsea- area farmer donates mammoth remains to University of Michigan
- Life Sciences - Oct 5 Bacteria in the world’s oceans produce millions of tonnes of hydrocarbons each year
- Medicine - Oct 5 Patient, test thyself
- Administration - Oct 5 Penn’s Dennis Culhane Co-authors New Report on Homelessness in the Developing World
- Chemistry - Oct 5 Former astronaut Helen Sharman finds a new space at Imperial
- Physics - Oct 5 Transmission of torque at small scales: the nanoclutch
Stopping cell migration may help block fibrosis and the spread of cancer
Discoveries by a Yale-led team of scientists could lead the way for development of new therapies for treating fibrosis and tumor metastasis. The researchers have both uncovered a signaling pathway that promotes cell migration in certain forms of pulmonary fibrosis, a deadly lung disease, and developed a drug treatment that may block the cancer cell migration. The study appears in the Advance Online Publication of Nature Cell Biology.
Pulmonary fibrosis is the development of excessive connective tissue in the lungs. It can develop without a known cause, and produces permanent scar tissue in the lungs. There is no known cure or treatment to slow down its progress.
Cell migration is the biological process by which cells move around the body, often contributing to the development or spread of diseases such as fibrosis or metastatic cancer.
Fibroblast connective tissue cells and cancer cells migrate in a way that requires sustained activation of signaling pathways. But until now the regulation of these cellular functions has been poorly understood. The Yale team studied the workings of a stimulant of cell migration known as lysophosphatidic acid (LPA). They identified the chemical reactions that ultimately induce cell migration, but more importantly, discovered a way to block the pathway via inhibition of the proteins responsible for promoting the migration.
Senior author Dianqing (Dan) Wu, professor of pharmacology and vascular biology at Yale School of Medicine and member of Yale Cancer Center, explained, "Our ability to block the pathway provides a potential therapeutic target for treating pulmonary fibrosis, a very serious disease that lacks effective treatments, and other types of fibrosis. Because cancer cells, particularly melanoma and lung cancer cells containing activated BRAF genetic mutations, can use this signaling pathway to migrate, blocking this pathway could also prevent metastasis of these cancers."
Other authors are Xiaoqing Gan, Jiyong Wang and Chen Wang of Yale; Eeva Sommer and Dario Alessi of the University of Dundee; Tohru Kozasa of the University of Illinois at Chicago; Srinivasa Srinivasula of the National Cancer Institute; Stefan Offermanns of the Max-Planck-Institute for Heart and Lung Research; and Melvin I. Simon of the University of California at San Diego.
Last job offers
- Veterinary Science - 5.10
Amtstierärztin / Amtstierarzt als Abteilungsleitung
- Administration/Government - 5.10
Leitung des Bergischen Veterinär- und Lebensmittelüberwachungsamtes (m/w)
- Chemistry - 5.10
Dozentin / Dozent Chemie für Umweltingenieure (100 %)
- Social Sciences - 2.10
Senior Projektleiter/in F&E (80%)
- Business/Economics - 2.10
Junior Researcher VWL (60-80%) / Wissenschaftliche/r Mitarbeiter/in (60-80%)
- Social Sciences - 2.10
Wissenschaftliche/r Mitarbeiter/in 60%
- Pedagogy/Education Science - 5.10
Assistant Professor in Energy Systems Modeling and Simulation
- Medicine/Pharmacology - 5.10
Assistant Professor in Inflammatory Origin of Depression
- Law/Forensics - 2.9
Universitätsprofessur für Smart Grids am Institut für Vernetzte und Eingebettete Systeme
- Media Sciences - 2.9
Universitätsprofessur für Visuelle Kultur am Institut für Medien- und Kommunikationswissenschaft
- History/Archeology - 5.10
Professur (W3) für Ur- und Frühgeschichte mit Schwerpunkt "Jüngere Steinzeiten"
- Physics/Materials Science - 5.10
Professorship in Experimental Physics
- Computer Science/Telecom - 5.10
Professor / Associate Professor in Computer Science
- Administration/Government - 2.10
Assistant Director (Associate Professor: Educational and Professional Development)
- History/Archeology - 6.10
International Studies & History - Assistant, Associate, or Full Professor (AA14240)
- History/Archeology - 5.10