Laboratory Specialist (80-100%) Membrane Protein and Nanobody Expression and Purification

Closing Date
WorkplaceVilligen, North West Switzerland, Switzerland
Occupation rate
80% - 100%
Job Start01.07.2021

The company

Founded in 2015, leadXpro AG is a lead compound discovery company focusing on membrane protein drug targets such as GPCRs, ion-channels and transporters for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression, purification and engineering, the preferred access to synchrotron/free electron laser (SLS/SwissFEL) for X-ray analysis and cryo-EM facilities (Uni Basel), leadXpro is able to characterize the interaction of small molecules and biotherapeutics with drug targets timely to impact the drug discovery of novel therapeutics. The position at leadXpro is an excellent opportunity to join a young and exciting company engaged in cutting-edge applied research. leadXpro is located at PARK INNOVAARE, 5234 Villigen, Switzerland. For more information, please visit: ?" target="_blank" rel="nofollow">


The position

leadXpro is urgently seeking a highly motivated and enthusiastic Laboratory Specialist who will be part of an interdisciplinary team of scientists working on leadXpro proprietary and partnered projects, within a highly collaborative international environment. You will have technical expertise in membrane protein and nanobodies expression and purification.

Key tasks and responsibilities

You are expected to work within a dynamic team that values transparency, integrity, reliability and a passion for science to create benefits for patients.

Key duties include:

  • Performing scientific research in the field of membrane proteins
  • Maintaining cultures of insect and mammalian cells and generation of baculoviruses
  • Screening of expression conditions using fluorescence-based techniques and Western blot
  • Optimization and upscaling of recombinant protein expression
  • Purification of membrane proteins using chromatography methods (affinity, ion exchange and size exclusion chromatography)
  • Monitoring of protein quality and purity using fluorescence-size exclusion chromatography and SDS-PAGE
  • Maintenance of laboratory records and participation in data analysis
  • Taking part in laboratory organization and maintenance of supplies and equipment


Your qualifications

You should preferably have a Master of Science in chemistry, biochemistry, molecular biology, biotechnology or a related discipline. Hands-on experience with membrane protein expression, purification as well as standard protein analytical techniques is expected. A track record of successful work on membrane proteins and nanobodies is of advantage. Excellent communication skills and fluency in English is essential.

Contact and Address

How to apply

If you are interested to join the team, please send your full application in English language with the keyword “Laboratory Specialist” in the subject line to:

The deadline for the application is March 10th.



In your application, please refer to and reference JobID 1493676.

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