Research Technician in Molecular Bioengineering for Organoids work

WorkplaceZürich, Zurich region, Switzerland
Research Technician in Molecular Bioengineering for Organoids work

80%-100%, Zurich, fixed-term

The laboratory of Neuroepigenetics at the Medical Faculty of the University Zürich and the Department of Health Science and Technology (D-HEST) of ETH Zürich, Switzerland is looking for a part- or full-time research technician to work on a project to develop 3D testicular organoid models for genetic/epigenetic editing.

Job description

The project is at the interface between bioengineering, reproductive biology and genetics/epigenetics and aims to establish two testicular organoid mouse models:
1) a 3D model based on the reconstitution of spheroids from dissociated testicular cells, and 2) a testis-on-chip model using microfluidics. The technician will have to establish these models based on existing protocols and transgenic mice, optimize their quality, reproducibility and reliability, and design and apply strategies for genetic and epigenetic editing in organoid cells using CRISPR tools and for multi-omics analyses. The overall goal is to study the biological mechanisms of epigenetic inheritance by a testing hypothesis based on findings made in a transgenerational mouse model of early life stress by the lab.

The technician will join a team of biologists, epigeneticists and bioinformaticians working on the molecular mechanisms of epigenetic inheritance and be embedded in a collaborating team of experts in bioengineering and microfluidics in the Department of Chemistry and Applied Biosciences at ETH Zürich.

Your profile

You should be highly motivated and have a strong interest in biomedical research and in the development of novel technologies to address important biological questions for health and disease. Hands-on expertise in bioengineering and technical skills in cell and organoid culture, and molecular biology at the Master's or doctoral level are required. You have some experience in quantitative microscopy and omics including library design and preparation, transfection and viral transduction, and flow cytometry are needed. Knowledge of reproductive biology and developmental biology is an advantage.
Furthermore, you are expected to be able to plan, execute and interpret complex experiments, work independently, be proactive in protocol development and troubleshooting, be solution-driven, be proficient in recording, tracking and presenting experimental results accurately, and be a good team player. The project is initially for 3-4 years with a possible extension.

We offer

ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.

Working, teaching and research at ETH Zurich

We value diversity

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So are we.

Applications including a CV, a description of previous research, and a letter of motivation should be sent to Isabelle Mansuy ( ), Laboratory of Neuroepigenetics, UZH and ETH. Further details on the project can be obtained by email or phone (044 635 3360). The position is available starting in fall 2022 or any time upon agreement and is located at the Brain Research Institute, University of Zürich, Irchel Campus, Winterthurerstrasse 190, 8057 Zürich.

For recruitment services, the GTC of ETH Zurich

Apply online now

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

In your application, please refer to and reference JobID 2351888.