Illustration for nuclear F-actin working to reshape the nucleus and organise the genome
Claudia Stocker VividBiology.
University of Bristol research has revealed how cells rebuild their nucleus and organise their genome when they divide - a discovery which could have major implications for understanding cancer and degeneration. When cells divide, they need to rebuild their nucleus and organise their genome. New collaborative research from the University of Bristol demonstrates how cells achieve this through the unexpected deployment of filamentous actin (F-actin) to the nucleus. The research, published online , provides the first evidence that actin polymerisation in the nucleus helps in reshaping the nucleus and reorganising the genome after cell division (mitosis). In mammals, including humans, the cell nucleus packages and protects the genome. When human cells divide, the nucleus is dissembled to allow segregation of the chromosomes. Once chromosome segregation is complete, new cells need to re-build their nucleus and organise their genome.
TO READ THIS ARTICLE, CREATE YOUR ACCOUNT
And extend your reading, free of charge and with no commitment.
