University of Birmingham launches Technical Academy

One of the UK’s leading microbiologists is concerned that confusing language and a lack of specific objectives are hampering the global fight against antibiotic-resistant infections.

Professor Laura Piddock , of the Institute of Microbiology and Infection, at the University of Birmingham, and her collaborators have written a report for the UK All-Party Parliamentary Group on Antibiotics. It calls for policymakers to focus on measurable objectives and simple language, among other things.

A summary of the report, ‘Implementing WHO, EU and UK AMR strategies and action plans: has the world lived up to the challenge?’, was today published in The Lancet Infectious Diseases).

The World Health Organization (WHO) submitted a European Strategic Action Plan on Antibiotic Resistance to the WHO European Regional Committee in 2011. The plan highlighted seven strategic objectives as guidance to national governments in European member states to address antibiotic use and resistance.

In response, the EU and the UK government set out to devise their own plans to address the recommendations in the WHO policy document.

The evidence (spanning October 2014 to March 2017) reviewed for the report suggested that although some EU member states successfully implemented many of the WHO recommendations, some appear to have been overlooked.

In particular, there was a lack of evidence to suggest any activity to restrict non-prescription use of antibiotics by people or off-label veterinary use of certain new or critically important antibiotics to human medicine.

Likewise, it appears that little has been done to evaluate the need for incentives to stimulate discovery, research and development of veterinary medicines to increase the likelihood that drugs will reach the market at the rate required to combat AMR.

Professor Piddock, who produced the report while Director of Antibiotic Action - the public engagement arm of the British Society for Antimicrobial Chemotherapy , said: “The UK has taken significant steps to meet the objectives of the EU Action Plan, which in turn satisfies the WHO Europe Strategic Action Plan.

“Yet there is an absence of objective and tangible outcomes by which to measure success of these plans and strategies. There is also a lack of consistency between the strategies in use of terminology, areas of compliance, and recommendations, which makes it difficult to discern whether the EU and UK regional action plans have satisfied the overarching WHO Action Plan.

“The biggest weakness is the ambiguous nature of the words employed in the recommendations. This ‘jargon’ may limit the impetus for decisive government action in some areas and pose a challenge to finding evidence of fulfilment of the AMR strategy aims.”

The report made the following recommendations for use in future action plans to combat AMR:

  • Use more specific and measurable objectives, and outline the means by which all activities should be evaluated, into all future strategies
  • Demonstrate how all future strategies should comply/align with the WHO Action Plan
  • Develop a harmonised collection of educational tools to address the problems of AMR and antimicrobial stewardship practices for both the public and those working in the healthcare and veterinary sectors
  • Use simple language in all communications
  • Monitor the efficacy of education campaigns through online channels
  • Coordinate a review of progress in the discovery, research, and development of new drugs, including for the veterinary sector.