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Pharmacology - Life Sciences - 22.03.2019
How new ketamine drug helps with depression
On March 5, the Food and Drug Administration (FDA) approved the first truly new medication for major depression in decades. The drug is a nasal spray called esketamine, derived from ketamine-an anesthetic that has made waves for its surprising antidepressant effect.   Because treatment with esketamine might be so helpful to patients with treatment-resistant depression (meaning standard treatments had not helped them), the FDA expedited the approval process to make it more quickly available.

Chemistry - Pharmacology - 22.03.2019
Inert Nitrogen Forced to React with Itself
Inert Nitrogen Forced to React with Itself
03/22/2019 Direct coupling of two molecules of nitrogen: chemists from Würzburg and Frankfurt have achieved what was thought to be impossible. This new reaction is reported and opens new possibilities for one of the most inert molecules on earth. Constituting over 78 % of the air we breathe, nitrogen is the element found the most often in its pure form on earth.

Health - Pharmacology - 21.03.2019
New class of membranes shown to regenerate tissue and bone, viable solution for periodontitis
New class of membranes shown to regenerate tissue and bone, viable solution for periodontitis
Periodontitis affects nearly half of Americans ages 30 and older, and in its advanced stages, it could lead to early tooth loss or worse. Recent studies have shown that periodontitis could also increase risk of heart disease and Alzheimer's disease. A team of UCLA researchers has developed methods that may lead to more effective and reliable therapy for periodontal disease — ones that promote gum tissue and bone regeneration with biological and mechanical features that can be adjusted based on treatment needs.

Chemistry - Pharmacology - 21.03.2019
With a 'hello,' Microsoft and UW demonstrate first fully automated DNA data storage
With a ’hello,’ Microsoft and UW demonstrate first fully automated DNA data storage
Researchers from the University of Washington and Microsoft have demonstrated the first fully automated system to store and retrieve data in manufactured DNA - a key step in moving the technology out of the research lab and into commercial data centers. In a simple proof-of-concept test, the team successfully encoded the word "hello" in snippets of fabricated DNA and converted it back to digital data using a fully automated end-to-end system, which is described in a new paper published March 21 in Nature Scientific Reports.

Computer Science / Telecom - Pharmacology - 21.03.2019
Data sharing by popular health apps is
Data sharing by popular health apps is "routine"
Researchers call for greater regulation and transparency as analysis of medicines-related apps found most directly shared user data - including sensitive health data - with third parties, posing an unprecedented privacy risk. Mobile health apps are a booming market targeted at both patients and health professionals.

Health - Pharmacology - 20.03.2019
Researchers identify potential new combination treatment for pancreatic cancer
Researchers identify potential new combination treatment for pancreatic cancer
FINDINGS Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world's deadliest cancers. The combination approach uses one drug that inhibits the process — known as lysosome — that allows cancer cells to recycle essential nutrients to survive, and another drug that blocks the pathway used to repair DNA.

Pharmacology - Health - 20.03.2019
Giving cancer patients a voice
Giving cancer patients a voice
UCLA's Dr. Patricia Ganz is co-leading a study to understand treatment tolerability by including the patient's feedback in cancer research Duane Bates Far too often, cancer patients and their doctors aren't aware of all the side effects that accompany new cancer therapies. Some of these new medications might cause fatigue, muscle aches, general pain and discomfort.

Life Sciences - Pharmacology - 20.03.2019
Nicotine addiction from vaping is a bigger problem than teens realize
As the vaping epidemic continues, researchers point to well-known health risks associated with nicotine. Data show clearly that young people are vaping in record numbers. And despite the onslaught of reports and articles highlighting not only its dangers but the marketing tactics seemingly aimed to hook teens and young adults, the number of vaping users continues to climb.  These teens may be overlooking (or underestimating) a key ingredient in the vapors they inhale: nicotine.

Health - Pharmacology - 18.03.2019
Shows novel use of mosquito-killing drug may reduce childhood malaria
Childhood malaria episodes could be reduced by 20% during malaria transmission season if an entire village population were given the mosquito-killing drug ivermectin or IVM every three weeks, according to a new study published in The Lancet international medical journal. The study represents the first scientific evidence that repeated mass administration of IVM can reduce malaria incidence in children aged five or younger without an increase in adverse events for the wider population given the drug, the researchers said.

Pharmacology - Health - 18.03.2019
Caterpillars could hold the secret to new treatment for Osteoarthritis
A substance from a fungus that infects caterpillars could offer new treatment hope for sufferers of osteoarthritis according to new research. Cordycepin is an active compound isolated from the caterpillar fungus Cordyceps militaris and has proved to be effective in treating osteoarthritis by blocking inflammation in a new way, through reducing a process called polyadenylation.

Life Sciences - Pharmacology - 14.03.2019
A new approach to drugging a difficult cancer target
A new approach to drugging a difficult cancer target
Study suggests an alternative way to treat tumors that are dependent on the cancer-promoting Myc protein. One of the most common cancer-promoting genes, known as Myc, is also one of the most difficult to target with drugs. Scientists have long tried to develop drugs that block the Myc protein, but so far their efforts have not been successful.

Pharmacology - Health - 13.03.2019
New cholesterol-lowering drug could help patients unable to take statins
New cholesterol-lowering drug could help patients unable to take statins
A new class of oral cholesterol-lowering drug could help patients unable to take statins due to side effects. The findings come from the largest study to date to test the effectiveness and safety of bempedoic acid, an oral medication - yet to be approved in Europe - which inhibits the body's ability to create the building blocks of cholesterol.

Health - Pharmacology - 13.03.2019
Stress hormones promote breast cancer metastasis
It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones. In addition, they found that synthetic derivatives of stress hormones, which are frequently used as anti-inflammatory in cancer therapy, decrease the efficacy of chemotherapy.

Pharmacology - Health - 13.03.2019
Molecular patterns could better predict breast cancer recurrence
The genetic and molecular make-up of individual breast tumours holds clues to how a woman's disease could progress, including the likelihood of it coming back after treatment, and in what time frame, according to a study published in Nature.

Pharmacology - Health - 13.03.2019
Therapy could improve, prolong sight in those suffering vision loss
Therapy could improve, prolong sight in those suffering vision loss
Millions of Americans are progressively losing their sight as cells in their eyes deteriorate, but a new therapy developed by researchers at the University of California, Berkeley, could help prolong useful vision and delay total blindness. The treatment - involving either a drug or gene therapy - works by reducing the noise generated by nerve cells in the eye, which can interfere with vision much the way tinnitus interferes with hearing.

Pharmacology - Health - 13.03.2019
"Inactive" ingredients may not be
Most pills contain compounds with potential to cause allergic reactions or discomfort in some patients. These compounds, known as "inactive ingredients," help to stabilize the drug or aid in its absorption, and they can make up more than half of a pill's mass. While these components are usually considered benign, a new study from MIT and Brigham and Women's Hospital has found that nearly all pills and capsules contain some ingredients that can cause allergic reactions or irritations in certain patients.

Pharmacology - Health - 11.03.2019
Repurposing older drugs could raise new hope for breast cancer treatment
An estimated 15 to 20 percent of all breast cancer patients are "triple negative," meaning women lack three crucial treatment targets-the estrogen receptor, the progesterone receptor and human epidermal growth factor receptor 2. Because they lack these targets, most triple negative patients are treated with standard chemotherapy, rather than the preferred targeted drugs.

Health - Pharmacology - 11.03.2019
Zinc could help as non-antibiotic treatment for UTIs
Zinc could help as non-antibiotic treatment for UTIs
New details about the role of zinc in our immune system could help the development of new non-antibiotic treatment strategies for bacterial diseases, such as urinary tract infections (UTIs). UTIs are one of the most common bacterial infections worldwide with about 150 million cases each year, and can lead to serious conditions such as kidney infection and sepsis.

Pharmacology - Health - 07.03.2019
Potential new treatment for heart attack
Scientists have found a potential new drug for treating the heart damage caused by a heart attack - by targeting the way the heart reacts to stress. This is the finding of new research, by scientists at Imperial College London and published in the journal Cell Stem Cell. There are no existing therapies that directly address the problem of muscle cell death Professor Michael Schneider Study author The research team, part-funded by the British Heart Foundation (BHF) used stem cells to grow heart tissue and mimic a ‘heart attack in a dish'.

Health - Pharmacology - 07.03.2019
Targeting inflammation for new Parkinson’s disease treatments
Researchers from The University of Queensland will investigate the potential of existing drugs to be repurposed to fight Parkinson's disease thanks to a new research grant. The research will be funded by The Michael J. Fox Foundation for Parkinson's Research and Shake It Up Australia Foundation and headed by UQ Centre for Clinical Research Group Leader Dr Richard Gordon.
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