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Health - Pharmacology - 10.06.2019
Improving breast cancer treatment
Millions of patients with incurable breast cancer could benefit from Welsh-led research which shows it is possible to control the cancer for twice as long by combing an investigational therapy with standard treatment. Oestrogen receptive positive breast cancer can be treated by drugs, such as fulvestrant, that interfere with the action of oestrogen.

Health - Pharmacology - 09.06.2019
Immunotherapy delays type 1 diabetes in people at high risk
A drug that targets the immune system can delay the onset of type 1 diabetes in people at high risk of developing the disease, said a Yale investigator who led the National Institutes of Health-funded Diabetes TrialNet study. The research is the first to show that the progression of type 1 diabetes can be slowed by two or more years with immunotherapy.

Mathematics - Pharmacology - 07.06.2019
New technique will help experts make heads or tails of male fertility
A new way of analysing sperm that tracks the movement of the sperm tail could enable substantial improvements to male fertility testing. The technique measures the speed and action of the sperm flagellum, or tail, which provides vital information for understanding whether sperm in an ejaculate have the potential to reach and fertilise the egg.

Health - Pharmacology - 06.06.2019
International partnership investigates causes of prostate cancer
United Kingdom and Kenyan experts are leading a major new international research project to investigate the causes of prostate cancer in East African men. Researchers from the University of Birmingham, the University of Nottingham, and the Kenya Medical Research Institute (KEMRI) will investigate the importance of immune cells and immune signals in male patients in Kenya and the UK.

Pharmacology - Health - 06.06.2019
Three-drug combination helps curb the growth of deadly type of skin cancer
A UCLA-led research team has pinpointed a three-drug combination that could prove to be an effective new therapy for people with a specific type of advanced melanoma. The approach shows promise for extending the lives of people with a type of melanoma that contains a potent gene mutation, BRAF V600E.

Health - Pharmacology - 05.06.2019
TAVR is helping people avoid open heart surgery
There was big news on Twitter this spring. The Rolling Stones tweeted that Mick Jagger, who is 75 and had been diagnosed with a heart problem, underwent a procedure and was expected to be back on the stage as soon as possible. His timing was spot on. Jagger had been diagnosed with aortic stenosis, a narrowing of his aortic valve.

Pharmacology - Health - 04.06.2019
Beta blockers reduce stress-induced irregular heart rhythm
Taking beta blockers - medications that reduce blood pressure and treat many heart conditions - can blunt the negative effects of stress and anger on people with a history of atrial fibrillation, or irregular heart rhythm, said Yale researchers. This strategy could potentially improve quality of life for many of the two million Americans with the condition, according to a new study.

Pharmacology - Health - 03.06.2019
Role of bacteria in drug response
Yale researchers identified human gut microbes that metabolize over 150 therapeutic drugs, a finding that highlights the role bacteria play in determining how well individuals respond to medications, they report June 3 . Scientists in the lab of senior author Andrew Goodman of Yale's Microbial Sciences Institute and the Department of Microbial Pathogenesis also pinpointed the microbial genes responsible for many of these drug-metabolizing activities.

Health - Pharmacology - 01.06.2019
Immunotherapy improves five-year survival rate of people with advanced lung cancer
In a study led by UCLA investigators, treatment with the immunotherapy drug pembrolizumab helped more than 15% of people with advanced non-small cell lung cancer live for at least five years — and 25% of patients whose tumor cells had a specific protein lived at least that long. When the study began in 2012, the average five-year survival rate was just 5.5% for people with that type of cancer.

Pharmacology - Health - 31.05.2019
Law backs doctors who prescribe opioids to the dying
Law backs doctors who prescribe opioids to the dying
Some doctors fear litigation and professional ruin if they are seen to have overprescribed opioids to terminally ill patients, according to a University of Queensland researcher. Palliative care expert Professor Geoffrey Mitchell said opioid overuse and some states' new assisted dying legislation had put end-of-life care clinicians “between a rock and a hard place”.

Health - Pharmacology - 30.05.2019
'switch' that helps breast cancer spread around the body
’switch’ that helps breast cancer spread around the body
Researchers have unveiled clues into how breast cancer cells spread around the body. The early-stage research, led by scientists from Imperial College London and The Institute of Cancer Research , London, identified a genetic ‘switch' in breast cancer cells that boosts the production of a type of internal scaffolding.

Health - Pharmacology - 29.05.2019
Key link discovered between tissue cell type and different forms of arthritis
Pioneering research by scientists at the Universities of Birmingham and Oxford brings us a step closer to developing targeted therapies for inflammatory diseases. The research team shows, for the first time, that different types of fibroblasts - the most common cells of connective tissue in animals - are organised in different layers in the joint and are responsible for two very different forms of arthritis; osteoarthritis and rheumatoid arthritis.

Life Sciences - Pharmacology - 28.05.2019
Cranberries join forces with antibiotics to fight bacteria
The global spread of antibiotic resistance is undermining decades of progress in fighting bacterial infections. Due to the overuse of antibiotics in medicine and agriculture, we are on the cusp of returning to a pre-antibiotic era in which minor infections can once again become deadly. Therefore, countering the fall in antibiotic efficacy by improving the effectiveness of currently available antibiotics is a crucial goal.

Life Sciences - Pharmacology - 24.05.2019
Nerve stimulation could provide new treatment option for most common type of stroke
Research led by a UCLA scientist found that a new nerve stimulation therapy to increase blood flow could help patients with the most common type of stroke up to 24 hours after onset. A study of 1,000 patients found evidence that the technique, called active nerve cell cluster stimulation, reduced the patients' degree of disability three months after they suffered an acute cortical ischemic stroke, which affects the surface of the brain.

Health - Pharmacology - 23.05.2019
Trial of potential new treatment for type 1 diabetes
Researchers at Cardiff and Swansea Universities are running a new trial to investigate whether a medicine currently used for the skin condition psoriasis could also be used to help people with type 1 diabetes produce some of their own insulin. Over 300,000 people in the UK have Type 1 diabetes and the drug used to treat them - insulin - has not changed in 98 years.

Health - Pharmacology - 23.05.2019
WHRY funds studies on pain relief, cannabis, and sex differences in disease
Women's Health Research at Yale (WHRY) today announced funding for first-of-their-kind studies on pain relief, cannabis, and the genetic basis of sex differences across a broad range of ailments, including Alzheimer's disease and heart disease. " We are changing science to improve lives by addressing what makes us unique as individuals," said Dr. Carolyn M. Mazure, director of WHRY.

Innovation / Technology - Pharmacology - 22.05.2019
MaaT Pharma expands patent portfolio with three granted patents covering its microbiome restoration biotherapeutic platform
MaaT Pharma expands patent portfolio with three granted patents covering its microbiome restoration biotherapeutic platform
First patents to cover the fundamental processes for accessing the human gut microbiome as biotherapeutics. MaaT Pharma's microbiome sample collection and administration devices receive CE mark for use in collecting and administrating gut-derived samples as biotherapeutics to patients.

Pharmacology - Health - 21.05.2019
Using 3D to test personalised treatments in five days
Using 3D to test personalised treatments in five days
UNIGE researchers have developed a cell co-culture platform that can reproduce a patient's tumour in 3D and test the best treatment combinations for its specific case in just five days. Why doesn't the same treatment work in the same way for every patient? How can a drug's performance be optimised without causing side effects due to an excessive dosage? In an attempt to answer these questions, researchers at the University of Geneva (UNIGE), Switzerland, have devised a cell co-culture platform that reproduces a patient's tumour structure in 3D.

Pharmacology - Life Sciences - 20.05.2019
New method simplifies the search for protein receptor complexes, speeding drug development
For a drug to intervene in cells or entire organs that are not behaving normally, it must first bind to specific protein receptors in the cell membranes. Receptors can change their molecular structure in a multitude of ways during binding - and only the right structure will “unlock” the drug's therapeutic effect.

Pharmacology - Health - 17.05.2019
’Stepped’ treatment reduces drinking in patients with HIV
People with HIV who drink too much were more likely to reduce drinking after undergoing an approach to care known as integrated stepped alcohol treatment, according to a Yale-led study. The finding supports greater use of this treatment model in HIV clinics to improve outcomes for patients with both HIV and drinking problems, the researchers said.
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