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Pharmacology



Results 21 - 40 of 167.


Pharmacology - Health - 03.06.2019
Role of bacteria in drug response
Yale researchers identified human gut microbes that metabolize over 150 therapeutic drugs, a finding that highlights the role bacteria play in determining how well individuals respond to medications, they report June 3 . Scientists in the lab of senior author Andrew Goodman of Yale's Microbial Sciences Institute and the Department of Microbial Pathogenesis also pinpointed the microbial genes responsible for many of these drug-metabolizing activities.

Health - Pharmacology - 01.06.2019
Immunotherapy improves five-year survival rate of people with advanced lung cancer
In a study led by UCLA investigators, treatment with the immunotherapy drug pembrolizumab helped more than 15% of people with advanced non-small cell lung cancer live for at least five years — and 25% of patients whose tumor cells had a specific protein lived at least that long. When the study began in 2012, the average five-year survival rate was just 5.5% for people with that type of cancer.

Pharmacology - Health - 31.05.2019
Law backs doctors who prescribe opioids to the dying
Law backs doctors who prescribe opioids to the dying
Some doctors fear litigation and professional ruin if they are seen to have overprescribed opioids to terminally ill patients, according to a University of Queensland researcher. Palliative care expert Professor Geoffrey Mitchell said opioid overuse and some states' new assisted dying legislation had put end-of-life care clinicians “between a rock and a hard place”.

Health - Pharmacology - 30.05.2019
'switch' that helps breast cancer spread around the body
’switch’ that helps breast cancer spread around the body
Researchers have unveiled clues into how breast cancer cells spread around the body. The early-stage research, led by scientists from Imperial College London and The Institute of Cancer Research , London, identified a genetic ‘switch' in breast cancer cells that boosts the production of a type of internal scaffolding.

Life Sciences - Pharmacology - 28.05.2019
Cranberries join forces with antibiotics to fight bacteria
The global spread of antibiotic resistance is undermining decades of progress in fighting bacterial infections. Due to the overuse of antibiotics in medicine and agriculture, we are on the cusp of returning to a pre-antibiotic era in which minor infections can once again become deadly. Therefore, countering the fall in antibiotic efficacy by improving the effectiveness of currently available antibiotics is a crucial goal.

Life Sciences - Pharmacology - 24.05.2019
Nerve stimulation could provide new treatment option for most common type of stroke
Research led by a UCLA scientist found that a new nerve stimulation therapy to increase blood flow could help patients with the most common type of stroke up to 24 hours after onset. A study of 1,000 patients found evidence that the technique, called active nerve cell cluster stimulation, reduced the patients' degree of disability three months after they suffered an acute cortical ischemic stroke, which affects the surface of the brain.

Health - Pharmacology - 23.05.2019
Trial of potential new treatment for type 1 diabetes
Researchers at Cardiff and Swansea Universities are running a new trial to investigate whether a medicine currently used for the skin condition psoriasis could also be used to help people with type 1 diabetes produce some of their own insulin. Over 300,000 people in the UK have Type 1 diabetes and the drug used to treat them - insulin - has not changed in 98 years.

Health - Pharmacology - 23.05.2019
WHRY funds studies on pain relief, cannabis, and sex differences in disease
Women's Health Research at Yale (WHRY) today announced funding for first-of-their-kind studies on pain relief, cannabis, and the genetic basis of sex differences across a broad range of ailments, including Alzheimer's disease and heart disease. " We are changing science to improve lives by addressing what makes us unique as individuals," said Dr. Carolyn M. Mazure, director of WHRY.

Health - Pharmacology - 23.05.2019
New way to eliminate cancer stem cells in prostate cancer
New way to eliminate cancer stem cells in prostate cancer
Tumor stem cells from prostate cancer. The coloring with different fluorochromes highlights the extensive network of mitochondria (red/green) surrounding the cell nuclei (blue). A study by investigators at the Institute of Oncology Research (IOR, affiliated to USI Università della Svizzera italiana) reveals a new way to eliminate cancer stem cells (CSC) in prostate tumours and enhance treatment efficacy.

Innovation / Technology - Pharmacology - 22.05.2019
MaaT Pharma expands patent portfolio with three granted patents covering its microbiome restoration biotherapeutic platform
MaaT Pharma expands patent portfolio with three granted patents covering its microbiome restoration biotherapeutic platform
First patents to cover the fundamental processes for accessing the human gut microbiome as biotherapeutics. MaaT Pharma's microbiome sample collection and administration devices receive CE mark for use in collecting and administrating gut-derived samples as biotherapeutics to patients.

Pharmacology - Health - 21.05.2019
Using 3D to test personalised treatments in five days
Using 3D to test personalised treatments in five days
UNIGE researchers have developed a cell co-culture platform that can reproduce a patient's tumour in 3D and test the best treatment combinations for its specific case in just five days. Why doesn't the same treatment work in the same way for every patient? How can a drug's performance be optimised without causing side effects due to an excessive dosage? In an attempt to answer these questions, researchers at the University of Geneva (UNIGE), Switzerland, have devised a cell co-culture platform that reproduces a patient's tumour structure in 3D.

Pharmacology - Life Sciences - 20.05.2019
New method simplifies the search for protein receptor complexes, speeding drug development
For a drug to intervene in cells or entire organs that are not behaving normally, it must first bind to specific protein receptors in the cell membranes. Receptors can change their molecular structure in a multitude of ways during binding - and only the right structure will “unlock” the drug's therapeutic effect.

Pharmacology - Health - 17.05.2019
’Stepped’ treatment reduces drinking in patients with HIV
People with HIV who drink too much were more likely to reduce drinking after undergoing an approach to care known as integrated stepped alcohol treatment, according to a Yale-led study. The finding supports greater use of this treatment model in HIV clinics to improve outcomes for patients with both HIV and drinking problems, the researchers said.

Health - Pharmacology - 16.05.2019
’Smart’ insulin could prevent hypoglycemia during diabetes treatment
UCLA bioengineers and their colleagues have developed a new type of insulin that could help prevent hypoglycemia in people who use the drug to manage diabetes. The treatment is being evaluated for potential clinical trials and, if successful, could change diabetes care. The study was published in the Proceedings of the National Academy of Sciences.

Health - Pharmacology - 15.05.2019
Study identifies how cancer drug inhibits DNA repair in cancer cells
According to researchers at Yale Cancer Center , a cancer drug thought to be of limited use possesses a superpower of sorts: It is able to stop certain cancer cells from repairing their DNA in order to survive. The study, published today Translational Medicine , suggests that combining this drug, cediranib, with other agents could potentially deliver a lethal blow in cancer that uses a specific pathway - or process - to create DNA repair cells.

Pharmacology - Health - 14.05.2019
Decoy antibiotics could get around bacteria's defences
Decoy antibiotics could get around bacteria’s defences
Imperial medical students have helped to devise a new type of 'decoy' drug to tackle infections that are resistant to antibiotics. In tests with cell cultures, the new drug successfully killed a strain of drug-resistant bacteria. It works by delivering two antibiotics, one of which is effectively hidden.

Life Sciences - Pharmacology - 14.05.2019
Second grant to bring research to market
05/14/2019 Getting an accurate picture of the real-time transcriptional activity of a cell: This is the goal of a new research project at the University of Würzburg which is funded by the European Research Council. If you paid attention during biology lessons, you may remember that genetic information in human cells is contained in the cell nucleus as a DNA double helix.

Pharmacology - 13.05.2019
Biomarker reveals PTSD sufferers at risk of suicide
The risk of suicide among individuals with post-traumatic stress disorder (PTSD) is much higher than the general population, but identifying those individuals at greatest risk has been difficult. However, a team at Yale has discovered a biological marker linked to individuals with PTSD who are most likely to think about suicide, the researchers report May 13 in the journal Proceedings of the National Academy of Sciences.

Pharmacology - Health - 13.05.2019
Researchers identify faster, more effective drug combination regimens to treat tuberculosis
Tuberculosis is a potentially deadly though curable disease. Each year about 10 million people develop active cases, and 1.6 million people die. In addition, about 1.7 billion people around the world are infected with TB bacteria, which can lie dormant for weeks to years, then become active and cause disease in up to 10 percent of those who are infected.

Health - Pharmacology - 09.05.2019
Smart design could prevent drug resistance in new malaria treatments
Smart design could prevent drug resistance in new malaria treatments
Researchers have overcome malaria parasites' resistance to potential new drugs by studying how it evolves. In a paper published today in Cell Chemical Biology , scientists from the Francis Crick Institute and Imperial College London studied malaria parasites resistant to a promising new class of candidate antimalarial drugs.