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Health - Pharmacology - 03.07.2020
Exploring the sun and targeting cancer: News from the College
Exploring the sun and targeting cancer: News from the College
Here's a batch of fresh news and announcements from across Imperial. From commencing a space study despite COVID-19 challenges, to a new drug and diet combo treatment for cancer, here is some quick-read news from across the College. Operating a spacecraft in lockdown After launching in February , the European Space Agency's (ESA) Solar Orbiter spacecraft has successfully completed four months of technical verification, known as commissioning.

Pharmacology - Health - 03.07.2020
Popular chemotherapy drug may be less effective in overweight and obese women
Breast cancer patients who are overweight or obese might benefit less from treatment with docetaxel, a common chemotherapy drug, than lean patients. An international team of researchers based this conclusion on a retrospective analysis of data from a large clinical trial. Their study was published in the Journal of Clinical Oncology .

Health - Pharmacology - 03.07.2020
Researchers test tuberculosis vaccine combination for COVID-19
Sydney researchers are taking an innovative approach to designing potential COVID-19 vaccines - using a tuberculosis vaccine to deliver components of the SARS-CoV-2 virus. Early results from pre-clinical testing in mice are promising. Researchers at the University of Sydney and Centenary Institute are repurposing an existing tuberculosis vaccine to see if it can be used in a new way against COVID-19 to develop a novel vaccine.

Health - Pharmacology - 02.07.2020
Convalescent blood plasma given to COVID-19 patients
An Imperial researcher discussed a trial giving UK COVID-19 patients blood plasma from people who have recovered from coronavirus, in a recent talk. Professor Anthony Gordon, Chair in Anaesthesia and Critical Care at Imperial College London and a Consultant in Intensive Care Medicine at Imperial College Healthcare NHS Trust, is leading a trial to investigate whether convalescent plasma transfusions improve the speed of recovery and chances of survival for patients with COVID-19.

Health - Pharmacology - 02.07.2020
COVID-19 vaccine technology can be used for future pandemics, says expert
The researcher developing a potential new coronavirus vaccine said the technology behind it could also be used for future pandemics, in a recent talk. Professor Robin Shattock, from the Department of Infectious Diseases at Imperial College London, is leading the development of a candidate vaccine. It is currently being tested in human trials to establish whether it can be well tolerated and produce an effective immune response against COVID-19.

Health - Pharmacology - 01.07.2020
Breast cancer found earlier in states with expanded Medicaid
In a new  Yale Cancer Center  (YCC) study, researchers have demonstrated that a higher percentage of women with breast cancer had their disease diagnosed at an early stage in states with expanded Medicaid coverage through the Affordable Care Act (ACA). No such change was seen in states that didn't expand their coverage.

Chemistry - Pharmacology - 01.07.2020
A new ultrafast insulin
A new ultrafast insulin
Stanford researchers tested a new insulin drug in diabetic pigs and found that it was twice as fast-acting as traditional insulin. Researchers at Stanford University are developing a new insulin formulation that begins to take effect almost immediately upon injection, potentially working four times as fast as current commercial fast-acting insulin formulations.

Health - Pharmacology - 30.06.2020
Yale IDs test to detect blood vessel injury, predict survival in COVID-19
Researchers at Yale have found that injury to endothelial cells - the cells lining blood vessels - may be a key driver of COVID-19 severity and death. The findings, published in the June 30 edition of The Lancet Haematology, may help to explain the mysterious blood clotting seen in some patients with COVID-19, a condition associated with the most severe cases and death.

Health - Pharmacology - 30.06.2020
Researchers ID test that detects injury, predicts survival in COVID-19
Researchers at Yale have found that injury to endothelial cells - the cells lining blood vessels - may be a key driver of COVID-19 severity and death. The findings, published in the June 30 edition of The Lancet Haematology, may help to explain the mysterious blood clotting seen in some patients with COVID-19, a condition associated with the most severe cases and death.

Health - Pharmacology - 29.06.2020
Joint cell discovery offers new hope for people with Rheumatoid Arthritis
The key to swift treatments to cure the pain of rheumatoid arthritis has been found in the joints of people with the condition who are in longterm remission. The study - published today and led by the University of Glasgow in collaboration with Fondazione A.Gemelli IRCCS in Italy and the Versus Arthritis funded Research into Inflammatory Arthritis Centre (RACE) - found that people with arthritis in long-term remission had a difference in cell function which could settle inflammation and 'teach' nearby cells to repair the joint.

Health - Pharmacology - 29.06.2020
Faecal microbial transplantation more effective and less costly than antibiotics to treat C-diff infections
An innovative treatment for patients with Clostridium difficile infection (CDI) which uses transplanted gut bacteria to treat the infection, is a more effective and more cost-efficient treatment than using antibiotics, a new UK study has found. CDI is an infection of the bowel, which commonly affects people who have recently been treated in hospital, those with underlying conditions and patients over 65.

Pharmacology - Health - 29.06.2020
New heart valve could transform open heart surgery for millions of patients globally
New heart valve could transform open heart surgery for millions of patients globally
A new polymeric heart valve with a life span potentially longer than current artificial valves that would also prevent the need for the millions of patients with diseased heart valves to require life-long blood thinning tablets has been developed by scientists at the universities of Bristol and Cambridge.

Pharmacology - Health - 25.06.2020
Kidney medication ineffective
A major clinical trial has found the drug Allopurinol does not prevent worsening of kidney disease. University of Queensland researchers at the Translational Research Institute have found Allopurinol is ineffective in treating the condition, despite up to 20 per cent of kidney disease patients being prescribed the medication.

Life Sciences - Pharmacology - 24.06.2020
On brain swelling in children with cerebral malaria reveals potential new treatment approach
Research on brain swelling in children with cerebral malaria reveals potential new treatment approach Through investigating the causes of brain swelling in cerebral malaria - a devastating parasitic disease that is fatal for one in five children - scientists have found a potential new treatment approach that could be safely used to improve outcome.

Health - Pharmacology - 24.06.2020
Bacterial predator could help reduce COVID-19 deaths
A type of virus that preys on bacteria could be harnessed to combat bacterial infections in patients whose immune systems have been weakened by the SARS-CoV-2 virus that causes the COVID-19 disease, according to an expert at the University of Birmingham and the Cancer Registry of Norway. Called bacteriophages, these viruses are harmless to humans and can be used to target and eliminate specific bacteria.

Health - Pharmacology - 24.06.2020
Blocking a ’jamming signal’ can unleash immune system to fight tumors
Yale researchers have discovered a "jamming signal" that blocks a powerful immune system stimulant called interleukin-18 (IL-18) from reaching tumors, including in cancers that are resistant to conventional immunotherapy treatments, they report June 24 . The research team created a version of IL-18 that could not be jammed and significantly reduced tumors in mice that are resistant to current immunotherapy.

Life Sciences - Pharmacology - 24.06.2020
Faulty brain processing of new information underlies psychotic delusions, finds new research
Faulty brain processing of new information underlies psychotic delusions, finds new research
Problems in how the brain recognizes and processes novel information lie at the root of psychosis, researchers from the University of Cambridge and King's College London have found. Their discovery that defective brain signals in patients with psychosis could be altered with medication paves the way for new treatments for the disease.

Health - Pharmacology - 23.06.2020
Existing drugs may limit damage caused by HIV
Yale researchers have identified four drugs that may help minimize the long-term health effects of HIV infection, they report June 23 in the Journal of Clinical Investigation. Antiretroviral therapy has proved to be a life-saving treatment for those infected with HIV. Yet even after treatment, most patients still harbor latent HIV in some immune system cells.

Health - Pharmacology - 23.06.2020
The tricks of the immune system
The tricks of the immune system
How the T-cell response changes in chronic virus infections "The Covid-19 pandemic clearly demonstrates the importance of understanding how the immune system reacts to virus infections," says Dr. Kilian Schober. Together with an interdisciplinary team of researchers from Medicine, Biology and Bioinformatics, he is investigating how important agents in the body's immune system known as T lymphocytes or T cells react when a virus invades the organism and how the immune response changes when the infection becomes chronic.

Health - Pharmacology - 23.06.2020
First volunteers receive Imperial COVID-19 vaccine
The first healthy volunteers have now received a candidate coronavirus vaccine developed by researchers. The clinical team, who delivered a small dose of the vaccine to participants at a West London facility, are closely monitoring the participants and report they are in good health, with no safety concerns.
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