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Life Sciences - Pharmacology - 04.03.2020
Mouse trial shows gene therapy potential for treating childhood brain disorder
Mouse trial shows gene therapy potential for treating childhood brain disorder
Researchers have developed a gene therapy with potential for treating a debilitating childhood neurological condition. The approach, which has only been trialled so far in mice and human cells, is thought to be the first to successfully target a rare genetic condition called CDKL5 deficiency disorder.

Pharmacology - Economics / Business - 04.03.2020
Average cost of developing a new drug could be up to $1.5 billion less than pharmaceutical industry claims
Average cost of developing a new drug could be up to $1.5 billion less than pharmaceutical industry claims
The costs of bringing a new drug to market may be lower than has been previously claimed by the pharmaceutical industry, according to a study published today (Tuesday March 3, 2020) in the journal JAMA.

Pharmacology - Health - 27.02.2020
Metals could be the link to new antibiotics
Compounds containing metals could hold the key to the next generation of antibiotics to combat the growing threat of global antibiotic resistance. University of Queensland researchers, working with a network of international collaborators, have discovered 23 previously unexplored compounds containing metals such as silver, manganese, zinc, ruthenium and iridium that have antibacterial and antifungal activity.

Health - Pharmacology - 27.02.2020
Getting off of the blood sugar roller coaster
Channels McGill University News and Events McGill researchers are pioneering a new artificial pancreas system that provides life-changing support to people living with type 1 diabetes. By Ashley Rabinovitch For the 250,000 Canadians living with type 1 diabetes, the days of desperately trying to keep their blood sugar stable are coming to an end.

Health - Pharmacology - 26.02.2020
Gene therapy shows promise in tackling common cause of childhood blindness
Gene therapy shows promise in tackling common cause of childhood blindness
The results of a first-in-human clinical trial of gene therapy to treat a common cause of genetic blindness have shown partial reversal of sight loss in some patients. X-linked retinitis pigmentosa, caused by mutations in RPGR gene, is the most common cause of blindness in young people. The inherited mutations lead to degeneration of light sensitive cells (photoreceptors) beginning in early childhood leading to severe sight loss. Until now there has been no treatment for this disease.

Pharmacology - 26.02.2020
University of Birmingham nuclear physicist is honoured in ’power’ awards
A better understanding of the lived experience of people with schizophrenia would enable clinicians to help patients live with their condition, alongside treating symptoms with medication and psychotherapy, say experts at the University of Birmingham. According to researchers at the University, this approach would involve developing an understanding of 'self-disturbance' in schizophrenia - in which patients' sense of connection to themselves and to their actions is disrupted.

Social Sciences - Pharmacology - 25.02.2020
Computer-based treatment for adolescent anxiety shows promising results
For adolescents diagnosed with an anxiety disorder, a simple computer-based program known as attention training may offer relief, according to a new Yale-led study. In a promising finding, researchers discovered major reductions in anxiety among 64 youths after just four twice-weekly sessions of the attention training program.

Pharmacology - Health - 25.02.2020
Engaging with schizophrenia - experts argue for new approaches to treatment
A better understanding of the lived experience of people with schizophrenia would enable clinicians to help patients live with their condition, alongside treating symptoms with medication and psychotherapy, say experts at the University of Birmingham. According to researchers at the University, this approach would involve developing an understanding of 'self-disturbance' in schizophrenia - in which patients' sense of connection to themselves and to their actions is disrupted.

Life Sciences - Pharmacology - 24.02.2020
Researchers end decade-long search for mechanical pain sensor
Channels McGill University News and Events Researchers at McGill University have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain, laying the foundation for the development of powerful new analgesic drugs. The study, published in Cell , is the first to show that TACAN, a highly conserved protein among vertebrates whose function remained unclear, is in fact involved in detecting mechanical pain by converting mechanical pressures into electric signals.

Health - Pharmacology - 21.02.2020
Partnership policing with the University of Birmingham
Treatment of patients suffering from bile duct cancer could be improved by tailoring medication to the levels of a key protein in people with the disease, according to new research. Cholangiocarcinoma (CCA) is a deadly disease with few treatments, but researchers in the UK and Thailand have discovered that the PRH/HHEX protein is a key driver in the disease, with increased levels affecting the response of cancer cells to therapeutic drugs.

Pharmacology - Health - 21.02.2020
Drug cocktail holds promise for spinal injuries
Drug cocktail holds promise for spinal injuries
Scientists have discovered a combination of two commonly available drugs that could help the body heal spinal fractures. The early-stage research in rats, by a group of scientists led by Imperial College London , revealed two existing medications can boost the body's own repair machinery, by triggering the release of stem cells from the bone marrow.

Pharmacology - 21.02.2020
’Significant step’ in COVID-19 vaccine quest
A University of Queensland team has met a key milestone in their fast-tracked research to develop a vaccine for the coronavirus, COVID-19. In just three weeks, the team of researchers has created their first vaccine candidate in the laboratory and will move immediately into further development before formal pre-clinical testing.

Health - Pharmacology - 21.02.2020
A better diagnosis of rare diabetes to adapt treatment
A better diagnosis of rare diabetes to adapt treatment
Scientists highlight the importance of monogenic diabetes and the consequences in terms of care of a precise diagnosis. Diabetes affects more than 400 million people worldwide and is a major public health problem. Although commonly referred to as a single disease, it actually constitutes a group of metabolic disorders with hyperglycaemia as a common feature.

Pharmacology - Health - 20.02.2020
Artificial intelligence yields new antibiotic
Artificial intelligence yields new antibiotic
A deep-learning model identifies a powerful new drug that can kill many species of antibiotic-resistant bacteria. Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics.

Pharmacology - Health - 20.02.2020
Some antibiotics linked with birth defects
Children of mothers prescribed macrolide antibiotics during the first trimester of pregnancy are at an increased risk of major birth defects when compared with penicillin, and the drugs should be used 'with caution' according to a new UCL study. The study, published today in The BMJ , aimed to assess the association between macrolides - a class of drugs used to treat common bacterial infections - and major malformations such as heart and genital defects, as well as four neurodevelopmental disorders (cerebral palsy, epilepsy, ADHD, and autism spectrum disorder) in children.

Health - Pharmacology - 20.02.2020
Decision time predicts the risk of depression relapse
Decision time predicts the risk of depression relapse
In a study, researchers have shown that it is possible to predict the risk of relapsing into depression after stopping antidepressant medication. People who relapse take longer to decide how much effort to invest for a reward. Depressive disorder is a major public health problem with an unpredictable course.

Health - Pharmacology - 19.02.2020
Prospects of new treatments for diabetes through metabolic products of the intestinal flora
Channels McGill University News and Events In a study published in the journal Cell Reports , researchers at McGill University, Kyoto University and INSERM/University of Paris show that an organic compound produced by the intestinal flora, the metabolite 4-Cresol, exhibits protective effects against type 1 and type 2 diabetes by stimulating the proliferation and function of insulin-producing beta cells in the pancreas.

Pharmacology - 19.02.2020
Antiviral activity of chloroquine against coronaviruses discovered at KU Leuven in 2004
Chloroquine, an antimalarial medicine that has been on the international market since 1934, proves to be active against the novel SARS coronavirus type 2 (COVID-19).

Pharmacology - Health - 19.02.2020
Podcast: Coronavirus vaccine, global progress report and fighting racism
In this edition: Join the race to develop a Covid-19 vaccine, check in on the Sustainable Development Goals, and discover how to argue with a racist. Play the complete podcast (above) You can catch the podcast on all your favourite platforms. Just click on any of the icons below. OR listen to individual chapters: News: Solar Orbiter lift-off and cutting contrails - We follow Imperial's instrument aboard the Solar Orbiter spacecraft as it takes its first data in space , and find out how altitude changes of just 2000 feet can cut the environmental impact of aeroplane contrails.

Health - Pharmacology - 19.02.2020
Virtual games help people stand and walk in rehab
VR, activity monitors and handheld devices can increase the chances people will stand and walk, the largest trial into the effects of digital devices in rehabilitation, carried out through three hospitals, has found. Virtual reality video games, activity monitors, and handheld computer devices can help people stand as well as walk, the largest trial worldwide into the effects of digital devices in rehabilitation has found. Participants used on average four different devices while in hospital and two different devices when at home.