From left to right, Virginia Plá, Neus Barranco, Fernando Aguado and Irene Sánchez. Image: Fernando Aguado.
From left to right , Virginia Plá, Neus Barranco, Fernando Aguado and Irene Sánchez. Image: Fernando Aguado. Alzheimer's disease is the main neurodegenerative disease in old people for which there is no treatment or efficient prevention yet. Current diagnostic methods do not detect one of the earliest and most relevant alterations of the disease: the degree of synaptic dysfunction that shows the neuronal damage. A research study by the Intercellular Communication Group of the Faculty of Biology and the Institute of Neurosciences of the UB ( UBNeuro ), led by Professor Fernando Aguado, has discovered molecules in the cerebrospinal fluid of patients with Alzheimer's that may be a potential biomarker of damage to synapses, the structure that allows communication between neurons. The study has been published in the journal Translational Neurodegeneration , in an article whose first authors are the researchers Neus Barranco and Virginia Plá, and in which the PhD candidate Irene Sánchez has also participated. Also, among the participants in the study are Alberto Lleó and Daniel Alcolea, from the Unit of Memory of the Neurology Service at Hospital de la Santa Creu i Sant Pau and the Center for Networking Biomedical Neurodegenerative Diseases (CIBERNED); Isidro Ferrer, from the Department of Pathology and Experimental Therapeutics of the UB, the Hospital de Bellvitge, the Bellvitge Biomedical Research Institute (IDIBELL) and CIBERNED; and Reiner Fischer-Colbrie, from the Department of Pharmacology of the Medical University of Innsbruck (Austria).
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