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Life Sciences - Pharmacology - 22.05.2024
Hallucinogenic mushrooms to treat alcohol addiction
Hallucinogenic mushrooms to treat alcohol addiction
A ground-breaking study conducted by INSERM's Groupe de Recherches sur l'Alcool et les Pharmacodépendances (GRAP) opens up new therapeutic perspectives for the treatment of alcohol addiction with psilocybin, the active compound in hallucinogenic mushrooms. Published in the scientific journal Brain , their work confirms the potential of psilocybin to combat alcohol addiction, while shedding light on the molecule's hitherto unknown mechanisms of action.

Health - Pharmacology - 22.05.2024
Gentler cell therapies for blood cancer
Researchers have developed an approach to -deleting- a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells. Writing in the journal Nature, the team reports on the promising results obtained in animal experiments and with human cells in the laboratory.

Pharmacology - Health - 21.05.2024
Western-led analysis shows potential in new Alzheimer’s treatment
Alzheimer's disease is the most common cause of dementia, affecting more than 55 million people worldwide. Currently, the two main approaches for treatments to delay or slow its progression target the buildup of amyloid beta peptides - which form plaques in the spaces between nerve cells in the brain - and the buildup of tau protein, resulting in tangles which damage neurons.

Pharmacology - 20.05.2024
How beeswax could help families in warzones
Beeswax and local herbs could be crucial in helping families living in conflict zones store food, according to scientists from Cardiff University and Kharkiv Polytechnic Institute of National Technical University, Ukraine.

Health - Pharmacology - 16.05.2024
Pathoblockers, a Future Alternative to Antibiotics’
Researchers at Freie Universität Berlin and Charité - Universitätsmedizin Berlin "defanging" bacteria, rendering them harmless In most cases, antibiotics are a reliable form of protection against bacterial infections. They have saved billions of human lives since their introduction. This protection, however, is threatened by bacteria's resistance to classical antibiotics and by their aggressive pathogenicity.

Pharmacology - Life Sciences - 16.05.2024
A Second Chance for New Antibiotic Agent
Twenty years ago, a drug candidate was rejected due to its side effects. Researchers have now figured out how to potentially make a successor molecule more selective. An increasing number of bacteria have become resistant to many commonly used antibiotics. Researchers from Bochum have discovered a fresh opportunity for a potential active molecule whose predecessor was rejected: By studying its interaction with the bacterial target protein very precisely in three dimensions, they identified a previously undetected point of attack that could be targeted by this compound.

Health - Pharmacology - 16.05.2024
At the right time for tumours
By examining the immune modulations of tumours during the day, scientists from the University of Geneva and the LMU Munich are demonstrating their impact on the diagnosis and management of patients. The currently most promising anti-tumour treatments are immunotherapies, which aim to boost the action of the patients' immune system to fight cancer.

Pharmacology - 16.05.2024
Scientists brew killer bee beer
A new beer is being brewed by microbiologists, using extracts found in killer bees from Namibia. Scientists from Cardiff University have used brewer's yeast that resides in the gut microbiome of killer honeybees in Namibia and applied it to develop a unique craft beer. The Cardiff microbiologists originally visited Namibia as part of a project that unites Cardiff University and the University of Namibia for sustainable environmental development, when the scientists became interested in the Africanised honey bee - also known as the killer bee.

Pharmacology - Health - 15.05.2024
Study Paves the Way for an Active Agent Against Hepatitis E
A newly identified compound prevents a cellular enzyme from cleaving the virus particle. As a result, the virus can no longer infect cells. At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for one.

Health - Pharmacology - 14.05.2024
’Weight loss’ drug semaglutide linked to better heart health
The weight loss drug semaglutide delivers cardiovascular benefits irrespective of starting weight and amount of weight lost, according to preliminary findings from a UCL-led research team. The findings, presented at this year's European Congress on Obesity (ECO), suggest that even people with mild obesity or those not losing weight are likely to gain some cardiovascular advantage.

Health - Pharmacology - 13.05.2024
Birth by C-section more than doubles odds of measles vaccine failure
Researchers say it is vital that children born by caesarean section receive two doses of the measles vaccine for robust protection against the disease. A study by the University of Cambridge, UK, and Fudan University, China, has found that a single dose of the measles jab is up to 2.6 times more likely to be completely ineffective in children born by C-section, compared to those born naturally.

Health - Pharmacology - 13.05.2024
Limited efficacy of common local anaesthetic
Liposomal bupivacaine was launched on the market twelve years ago to provide long-lasting local control of pain. The medication is used as a local anaesthetic, particularly for orthopaedic operations. A research study by MedUni Vienna has now shown the limited effectiveness of the substance. The study has just been published in the journal "Anesthesiology", the peer-reviewed journal of the American Society of Anesthesiologists (ASA).

Health - Pharmacology - 13.05.2024
Cancer spread: targeting platelets to counter metastasis?
Scanning electron microscopy. Here we see how platelets (in blue/purple) attach to two tumour cells (in red) in a pre-clinical mouse model. Maria Jesus Garcia Leon (unit 1109 Inserm/Université de Strasbourg) What if our blood platelets , which play a major role in maintaining the integrity of our circulatory system, were not always on our side' Research teams from Inserm, Université de Strasbourg and the French Blood Establishment have studied their role in the process of metastasis formation.

Health - Pharmacology - 12.05.2024
Heart failure device could remotely monitor patients and prevent hospitalisation
A brand-new monitoring device for patients with heart failure may be able to detect signs of fluid overload, and could be used to monitor patients and help prevent hospital admissions, according to a new study.

Pharmacology - Health - 09.05.2024
New drug for sepsis
A new drug could prevent sepsis-related organ failure and death by restoring the health of a patient's blood vessels. Researchers from The University of Queensland and the Queensland Children's Hospital (QCH) have successfully tested the first-in-class drug in mice. Dr Mark Coulthard from UQ and the QCH 's Paediatric Intensive Care Unit said results from pre-clinical testing using human blood samples were also promising.

Health - Pharmacology - 09.05.2024
New treatment could reverse hair loss caused by an autoimmune skin disease
New treatment could reverse hair loss caused by an autoimmune skin disease
A microneedle patch that delivers immune-regulating molecules can teach T cells not to attack hair follicles, helping hair to regrow. Researchers at MIT, Brigham and Women's Hospital, and Harvard Medical School have developed a potential new treatment for alopecia areata, an autoimmune disorder that causes hair loss and affects people of all'ages, including children.

Health - Pharmacology - 08.05.2024
A third Covid vaccine dose improves defence for some clinically extremely vulnerable patients
A major clinical trial has found that an additional COVID 19 vaccine dose led to the majority of clinically extremely vulnerable people mounting defensive antibodies against Covid-19. New research published in The Lancet Rheumatology from the OCTAVE DUO research trial co-led by the University of Birmingham and University of Glasgow found that vaccine boosters led to improved antibody responses among many groups of immunocompromised and immunosuppressed patients.

Health - Pharmacology - 06.05.2024
New vaccine effective against coronaviruses that haven’t even emerged yet
Researchers have developed a new vaccine technology that has been shown in mice to provide protection against a broad range of coronaviruses with potential for future disease outbreaks - including ones we don't even know about Our focus is to create a vaccine that will protect us against the next coronavirus pandemic, and have it ready before the pandemic has even started.

Health - Pharmacology - 03.05.2024
UQ health research given $41 million boost
Researchers from The University of Queensland have received more than $41 million through the National Health and Medical Research Council (NHMRC) 2024 Investigator Grants to address health challenges. The 24 UQ researchers will lead projects from the development of pain killers and anti-epileptic drugs using venom, to improving patient outcomes for ovarian, endometrial and thyroid cancers.

Health - Pharmacology - 02.05.2024
Immunotherapy for lung cancer effective even before surgery
Blocking "switches" of the immune system has revolutionized the treatment of patients with various metastatic cancers. In 2018, the discovery of this principle was recognized by the Nobel Prize in Medicine. An international research team has now shown that the simultaneous inhibition of two "immune switches", PD-1 and LAG-3, can lead to the killing of lung cancer cells after just a few weeks.
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