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Health - Pharmacology - 26.01.2024
Research breakthrough could spare brain cancer patients risky surgery
A simple blood test could help diagnose patients with the deadliest form of brain cancer, sparing them from undergoing invasive, highly-risky surgery. In a world-first, the new technique has been proven for glial tumours including glioblastoma (GBM), the most commonly-diagnosed type of high-grade brain tumour in adults.

Health - Pharmacology - 25.01.2024
Digital pathology cleared for use in cancer screening programmes
New research funded by the National Institute for Health and Care Research (NIHR) has led to the UK government approving the use of digital pathology to help speed up analysis of cancer screening samples. This allows the benefits offered by digital pathology to be used to improve cancer screening particularly in bowel, breast, lung and cervical cancers.

Pharmacology - Health - 24.01.2024
Innovative dengue vaccine successfully tested
Innovative dengue vaccine successfully tested
Unisanté (University of Lausanne) has conducted a clinical study on a new type of vaccine that induces cellular immunity to combat dengue fever. The results have just been published in The Lancet eBioMedicine. They are positive and encourage further investigation. This approach is also promising for other diseases.

Health - Pharmacology - 23.01.2024
Mutating Hepatitis Viruses Make Drug Treatment More Difficult
Mutating Hepatitis Viruses Make Drug Treatment More Difficult
A combination therapy with multiple drugs is more effective than just one active compound. To begin with, at least. Hepatitis E affects over 20 million people worldwide. It clears up without any consequences in most cases, but it can pose a risk to pregnant women and immunocompromised patients. There are no specific active substances against the virus.

Health - Pharmacology - 23.01.2024
New therapeutic approach for the treatment of sarcoidosis
A research team led by Georg Stary (Medical University of Vienna and CeMM) has identified a new approach to treating the inflammatory disease sarcoidosis. In a clinical study, the inhibition of a specific signaling pathway showed clear success in the treatment of granulomas in the skin. This opens up new therapeutic paths for sarcoidosis and similar inflammatory diseases.

Pharmacology - Chemistry - 22.01.2024
New agent blocks stress response
New agent blocks stress response
If the body's natural stress response gets knocked off balance, it can result in physical and mental health disorders. Researchers at ETH Zurich have developed an agent capable of selectively inhibiting this response. Stress isn't merely an oppressive feeling we experience when we're overwhelmed; it's the body's natural reaction to acute or persistent strain.

Health - Pharmacology - 22.01.2024
A new drug candidate can shrink kidney cysts
A new drug candidate can shrink kidney cysts
A compound originally developed to treat cancer could be repurposed to treat polycystic kidney disease, an inherited condition that can lead to kidney failure. Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease, can lead to kidney enlargement and eventual loss of function.

Health - Pharmacology - 18.01.2024
Standing United: When Immune Cells Join Forces, Cancer Therapy Is More Effective
A new kind of immunotherapy, based on crosstalk between different immune cells, could pave the way for innovative treatments of cancer and autoimmune diseases Winning on the battlefield takes a combination of precise intelligence and resolute soldiers. But when it comes to the battle against cancer, the immune system's fighters - the T cells - quickly lose their ability to kill and become exhausted, while the intelligence-providing dendritic cells are scarce.

Pharmacology - Economics - 18.01.2024
A navigation system to combat bottlenecks in medication supply
A navigation system to combat bottlenecks in medication supply
A new model designed by researchers measures how flexible medication distribution systems are in real time. It shows that supply shortages can be eased if pharmaceutical wholesalers coordinate their inventories and reroute scarce products as flexibly as possible along existing supply chains. Supply bottlenecks for medications present major challenges to healthcare systems the world over.

Health - Pharmacology - 18.01.2024
Complement System Causes Cell Damage in Long Covid
Medicine Long Covid patients suffer from chronic symptoms such as fatigue or shortness of breath. As researchers at the University of Zurich and University Hospital Zurich have discovered, this is to some extent due to a part of our immune system called the complement system. The study identified a pattern in the blood proteins that will improve the diagnosis and perhaps also the targeted treatment of Long Covid.

Health - Pharmacology - 17.01.2024
Early detection of breast cancer
Early detection of breast cancer
Further TOSYMA analysis underpins advantages of DBT+SM use compared to the previous screening standard In diagnostics, finding more is not automatically better. Rather, it is about finding the right thing - especially in the case of such dangerous diseases as cancer. This is where early detection comes into play, but it can also have unwanted side effects: For example, there is a risk of also discovering non-aggressive tumors that lead to treatment - but would not have substantively impaired quality of life or become life-threatening in the course of the disease.

Health - Pharmacology - 17.01.2024
Kidney and heart diseases reduce survival rate after severe burns
Despite enormous medical advances, severe burns are still potentially life-threatening injuries. Clinical scores, which take relevant parameters into account, are available to doctors as a decision-making aid for therapeutic measures and to assess the probability of patient survival. Pre-existing diseases were not previously included in these models.

Pharmacology - Health - 17.01.2024
Spider venom heart drug a step closer
Spider venom heart drug a step closer
A spider venom molecule being investigated by a University of Queensland team has met critical benchmarks towards becoming a treatment for heart attack and stroke. Associate Professor Nathan Palpant Professor Glenn King from UQ's Institute for Molecular Bioscience have previously shown that the drug candidate Hi1a protects cells from the damage caused by heart attack and stroke.

Pharmacology - Health - 16.01.2024
Machine learning predicts response to drug for arthritis in children
Doctors might one day be able to target children and young people with arthritis most likely to be helped by its first-line treatment, thanks to the application of machine learning by University of Manchester scientists. Though methotrexate is the first-line drug to be given for Juvenile idiopathic arthritis (JIA), it is only effective or tolerated in half of the children and young people who receive it.

Pharmacology - Psychology - 16.01.2024
Coming off antidepressants can trigger emotional and social difficulties alongside physical symptoms
Coming off antidepressants can trigger emotional and social difficulties alongside physical symptoms
New research from the Dept of Psychology looked at physical and emotional withdrawal symptoms experienced by people taking antidepressants. Published on Tuesday 16 January 2024 Last updated on Tuesday 16 January 2024 Coming off antidepressants is known to trigger physical symptoms, such as restlessness, fatigue and excessive sweating, but new research suggests people can also experience emotional and social difficulties, and changes in their thinking patterns when they stop taking antidepressants like Prozac.

Health - Pharmacology - 16.01.2024
New Covid variants learn old tricks to stay ahead of immune defences
New Covid variants learn old tricks to stay ahead of immune defences
Recent SARS-CoV-2 variants such as BA.4 and BA.5 developed abilities missing from the first Omicron variants that allowed them to overcome humans' innate immunity, according to research from UCL. The study, published in Nature Microbiology , examined viral evolution in eight Omicron variants to better understand how the virus has reacted since the introduction of vaccinations 1 .

Health - Pharmacology - 16.01.2024
Breaking the Cycle of Negative Feedback to Enhance Cancer Immunotherapy
KU Leuven researchers discover how to break the negative feedback loop to improve cancer immunotherapy. Over the past years, immunotherapy has improved the outlook for many cancer patients. However, not all cancers respond to current immunotherapies. A research team led by KU Leuven discovered a key mechanism behind this lack of response, and it came up with an innovative solution.

Health - Pharmacology - 15.01.2024
Significant gaps in COVID-19 vaccine uptake may have led to over 7,000 hospitalisations and deaths
Significant gaps in COVID-19 vaccine uptake may have led to over 7,000 hospitalisations and deaths
Between a third and a half of the populations of the four UK nations had not had the recommended number of COVID vaccinations and boosters by summer 2022, according to the first research study to look at COVID-19 vaccine coverage of the entire UK population. These results can be used to help create health policy and public health interventions to improve vaccine uptake Angela Wood The findings, published today in The Lancet , suggest that more than 7,000 hospitalisations and deaths might have been averted in summer 2022 if the UK had had better vaccine coverage.

Chemistry - Pharmacology - 15.01.2024
Accelerating how new drugs are made with machine learning
Researchers have developed a platform that combines automated experiments with AI to predict how chemicals will react with one another, which could accelerate the design process for new drugs. A deeper understanding of the chemistry could enable us to make pharmaceuticals and so many other useful products much faster.

Health - Pharmacology - 12.01.2024
Morphine treatment and cheating sparrows: News from Imperial
Morphine treatment and cheating sparrows: News from Imperial
Here's a batch of fresh news and announcements from across Imperial. From research exploring why female sparrows might cheat, to a study that investigated how morphine can reduce coughing in patients, here is some quick-read news from across Imperial. Pick me Picky female sparrows may be more unfaithful, new Imperial research suggests.
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