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Results 41 - 60 of 217.


Health - Pharmacology - 13.05.2024
Cancer spread: targeting platelets to counter metastasis?
Scanning electron microscopy. Here we see how platelets (in blue/purple) attach to two tumour cells (in red) in a pre-clinical mouse model. Maria Jesus Garcia Leon (unit 1109 Inserm/Université de Strasbourg) What if our blood platelets , which play a major role in maintaining the integrity of our circulatory system, were not always on our side' Research teams from Inserm, Université de Strasbourg and the French Blood Establishment have studied their role in the process of metastasis formation.

Health - Pharmacology - 12.05.2024
Heart failure device could remotely monitor patients and prevent hospitalisation
A brand-new monitoring device for patients with heart failure may be able to detect signs of fluid overload, and could be used to monitor patients and help prevent hospital admissions, according to a new study.

Pharmacology - Health - 09.05.2024
New drug for sepsis
A new drug could prevent sepsis-related organ failure and death by restoring the health of a patient's blood vessels. Researchers from The University of Queensland and the Queensland Children's Hospital (QCH) have successfully tested the first-in-class drug in mice. Dr Mark Coulthard from UQ and the QCH 's Paediatric Intensive Care Unit said results from pre-clinical testing using human blood samples were also promising.

Health - Pharmacology - 09.05.2024
New treatment could reverse hair loss caused by an autoimmune skin disease
New treatment could reverse hair loss caused by an autoimmune skin disease
A microneedle patch that delivers immune-regulating molecules can teach T cells not to attack hair follicles, helping hair to regrow. Researchers at MIT, Brigham and Women's Hospital, and Harvard Medical School have developed a potential new treatment for alopecia areata, an autoimmune disorder that causes hair loss and affects people of all'ages, including children.

Health - Pharmacology - 08.05.2024
A third Covid vaccine dose improves defence for some clinically extremely vulnerable patients
A major clinical trial has found that an additional COVID 19 vaccine dose led to the majority of clinically extremely vulnerable people mounting defensive antibodies against Covid-19. New research published in The Lancet Rheumatology from the OCTAVE DUO research trial co-led by the University of Birmingham and University of Glasgow found that vaccine boosters led to improved antibody responses among many groups of immunocompromised and immunosuppressed patients.

Health - Pharmacology - 06.05.2024
New vaccine effective against coronaviruses that haven’t even emerged yet
Researchers have developed a new vaccine technology that has been shown in mice to provide protection against a broad range of coronaviruses with potential for future disease outbreaks - including ones we don't even know about Our focus is to create a vaccine that will protect us against the next coronavirus pandemic, and have it ready before the pandemic has even started.

Health - Pharmacology - 03.05.2024
UQ health research given $41 million boost
Researchers from The University of Queensland have received more than $41 million through the National Health and Medical Research Council (NHMRC) 2024 Investigator Grants to address health challenges. The 24 UQ researchers will lead projects from the development of pain killers and anti-epileptic drugs using venom, to improving patient outcomes for ovarian, endometrial and thyroid cancers.

Health - Pharmacology - 02.05.2024
Immunotherapy for lung cancer effective even before surgery
Blocking "switches" of the immune system has revolutionized the treatment of patients with various metastatic cancers. In 2018, the discovery of this principle was recognized by the Nobel Prize in Medicine. An international research team has now shown that the simultaneous inhibition of two "immune switches", PD-1 and LAG-3, can lead to the killing of lung cancer cells after just a few weeks.

Health - Pharmacology - 01.05.2024
Immune cells hunt down cancer around the body
Scientists have discovered the key features of immune B cells which make them successful at targeting tumours - including when cancer has spread to a different part of the body. Published in Nature Immunology , the researchers have developed a computational tool to identify these anti-cancer immune cells which could lead to improved, personalised immunotherapies.

Health - Pharmacology - 01.05.2024
Tsetse fly protein provides anti-clotting agent with its own on-off switch
A completely novel way to develop 'surpamolecules' for drug discovery could have application in immunotherapy as well as this breakthrough design for an anticoagulant with on-demand reversibility. Researchers at the University of Sydney and University of Geneva have developed a new anticoagulant, whose anticlotting action can be rapidly stopped 'on demand'.

Health - Pharmacology - 01.05.2024
Patients with rheumatoid arthritis have unique and complex autoantibody patterns
Patients with rheumatoid arthritis have unique and complex autoantibody patterns
Research challenges therapeutic approaches and ideas about disease backgrounds Patients with rheumatoid arthritis (RA) all'have a unique and diverse set of antibodies that are involved in the development of the disease. Researchers at Utrecht University unveiled the complexity of these antibodies using powerful lab tools capable of analysing our immune system at molecular levels.

Health - Pharmacology - 01.05.2024
Liver study pinpoints cell that helps healing process
A type of cell responsible for repairing damaged liver tissue has been uncovered for the first time by a team of scientists, including Professor Rajiv Jalan (UCL Liver & Digestive Health). The study, published in Nature , showed how these new-found cells migrate to the site of damage, providing new insights into the way the liver heals itself.

Pharmacology - Health - 29.04.2024
New phytocannabinoid discovered in sweet violet
New phytocannabinoid discovered in sweet violet
Cannabinoids are endogenous hormones or naturally occurring molecules found in various plants, most commonly known as THC (?9-tetrahydrocannabinol) in cannabis plants. The therapeutic potential of these compounds is the subject of intensive research, yet their psychoactive and addictive properties stimulate intensive debate.

Health - Pharmacology - 29.04.2024
Possible alternative to antibiotics produced by bacteria
Possible alternative to antibiotics produced by bacteria
Antibacterial substance from staphylococci discovered with new mechanism of action against natural competitors Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers at the University Hospital Bonn (UKB), the University of Bonn and the German Center for Infection Research (DZIF) have discovered a new so-called lantibiotic, namely epilancin A37.

Health - Pharmacology - 29.04.2024
Exercise programmes benefit a wide range of long-term health conditions
A new study looking at health data from the last 20 years has highlighted the benefits of exercise programmes for individuals living with long-term health conditions. Drawing on a comprehensive overview of published evidence spanning 39 different long-term conditions - and encompassing 990 randomised controlled trials and over 900,000 patients - the research underscores the fundamental role of exercise in enhancing the wellbeing of individuals living with long-term health conditions.

Health - Pharmacology - 26.04.2024
Azithromycin and preventing chronic lung disease in premature babies
The early use of azithromycin does not prevent the development of chronic lung disease in premature babies, finds new research by Cardiff University. The largest clinic trial for azithromycin and chronic lung diseases in premature babies has provided definitive answers to whether azithromycin can decrease rates of chronic lung disease in prematurely born babies.

Health - Pharmacology - 26.04.2024
New treatment for brain tumours approved following decades of work
The first ever targeted treatment for brain tumours in children has been approved for NHS patients, following over 20 years of research by a UCL clinician scientist. Professor Darren Hargrave, who is a researcher at the UCL Great Ormond Street Institute of Child Health and consultant at Great Ormond Street Hospital for Children (GOSH), was the Chair of the TADPOLE-G trial steering group, alongside researchers across the world.

Health - Pharmacology - 24.04.2024
Tumor cells evade the immune system early on
Tumor cells evade the immune system early on
Newly discovered mechanism could significantly improve cancer immunotherapies Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer. Researchers at the Technical University of Munich (TUM) and the Ludwig-Maximilians-Universität München (LMU) Hospital have now uncovered for the first time how this exactly happens.

Pharmacology - Chemistry - 24.04.2024
AI designs new drugs based on protein structures
AI designs new drugs based on protein structures
A new computer process developed by chemists at ETH Zurich makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein's three-dimensional surface. The new process could revolutionise drug research. "It's a real breakthrough for drug discovery," says Gisbert Schneider, Professor at ETH Zurich's Department of Chemistry and Applied Biosciences.

Health - Pharmacology - 24.04.2024
Biomarkers identified for successful treatment of bone marrow tumours
CAR T cell therapy has proven effective in treating various haematological cancers. However, not all patients respond equally well to treatment. In a recent clinical study, researchers from the University of Leipzig Medical Center and the Fraunhofer Institute for Cell Therapy and Immunology identified several biomarkers that are associated with the response to CAR T cell therapy in multiple myeloma, a malignant tumour disease in the bone marrow.