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Sport - Health - 19.01.2023
Running: the 10% progress rule questioned
Running: the 10% progress rule questioned
The belief that this rule will prevent injury is scientifically unfounded. This time, it's true, you're going to get in shape. If your plan is to do this by running, chances are that the program you find on the Internet or that is suggested to you by a trainer or friend will tell you that, to avoid injury, you should not increase your training volume by more than 10% each week.

Life Sciences - Health - 19.01.2023
Genetic overlap between twelve psychiatric disorders scrutinised
Genetic overlap between twelve psychiatric disorders scrutinised
Sorry! De informatie die je zoekt, is enkel beschikbaar in het Engels. You are not logged in yet to My study choice Portal. Login or create an account to save your programmes. In a study published in Nature Genetics, researchers of Amsterdam UMC teamed up with colleagues from the Complex Trait Genetics department of VU Amsterdam and the Million Veteran Program to scrutinize the genetic similarity of twelve psychiatric disorders.

Health - Life Sciences - 19.01.2023
Better understanding cancer and heart disease
A Canadian-led team of researchers finally identifies the molecular mechanism by which a key protein regulates LDL cholesterol. CONTENU Nabil G. Seidah Credit: IRCM In a crucial step towards understanding the mechanisms involved in cardiovascular disease and certain cancers, a Canadian led research team has succeeded in a world first: they've found the molecular mechanism by which the protein PCSK9 degrades the receptor of low density lipoproteins, the richest cholesterol particles in the bloodstream.

Health - 19.01.2023
At-home cardiac rehabilitation programme is a success in Scotland
REACH-HF, an award-winning cardiac rehabilitation programme which helps people living with heart failure improve their quality of life from the convenience and safety of their own homes, should be rolled out across Scotland, according to a new study. Led by researchers at the University of Glasgow, the SCOT:REACH-HF study followed more than 100 people with heart failure in Scotland as they participated in the REACH-HF programme.

Health - 19.01.2023
Specific immune response to Epstein-Barr virus discovered
Medicine & Science Medical science has not yet been able to explain why the Epstein-Barr virus triggers infectious mononucleosis (IM) in some people with initial infections and not in others. But now, a research team led by Elisabeth Puchhammer-Stöckl, head of the Center for Virology at MedUni Vienna, has identified a specific immune response to the virus as the cause, and as a potential target for the development of vaccines.

Pharmacology - Health - 19.01.2023
New hope for treatment of rare metabolic disease
Results of a controlled clinical trial with a new drug for the treatment of X-linked adrenoleukodystrophy To date, no pharmacological treatment exists for X-linked adrenoleukodystrophy, a progressive genetic metabolic disease that damages the adrenal glands, the spinal cord and the white matter of the nervous system.

Health - Computer Science - 19.01.2023
AI-powered database to design potential cancer drug in 30 days
AI-powered database to design potential cancer drug in 30 days
In less than a month, researchers have used AlphaFold, an artificial intelligence (AI)-powered protein structure database, to design and synthesize a potential drug to treat hepatocellular carcinoma (HCC), the most common type of primary liver cancer. The researchers successfully applied AlphaFold to an end-to-end AI-powered drug discovery platform called Pharma.AI.

Health - Life Sciences - 19.01.2023
Harnessing the healing power within our cells
University of Queensland researchers have identified a pathway in cells that could be used to reprogram the body's immune system to fight back against chronic inflammatory and infectious diseases. Dr Kaustav Das Gupta Professor Matt Sweet from UQ's Institute for Molecular Bioscience discovered that a molecule derived from glucose in immune cells can both stop bacteria growing and dampen inflammatory responses.

Pharmacology - Health - 19.01.2023
Chemotherapy before surgery cuts risk of colon cancer returning, trial finds
Chemotherapy before surgery cuts risk of colon cancer returning, trial finds
Patients with early stage colon cancer benefit from 6 weeks of chemotherapy before surgery Giving colon cancer patients chemotherapy before surgery cuts their risk of the disease coming back, according to the results of a Cancer Research UK-funded clinical trial. The FOxTROT trial showed that giving colon cancer patients chemotherapy before rather than after surgery reduced the chance of cancer returning within 2 years by 28%.

Health - Life Sciences - 19.01.2023
New nanocapsules deliver therapy brain-wide, edit Alzheimer's gene in mice
New nanocapsules deliver therapy brain-wide, edit Alzheimer’s gene in mice
Gene therapies have the potential to treat neurological disorders like Alzheimer's and Parkinson's diseases, but they face a common barrier - the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain's protective membrane to deliver brain-wide therapy with a range of biological medications and treatments.

Health - Psychology - 19.01.2023
Following pandemic, educators are not all right but meditation could ease burden
Following pandemic, educators are not all right but meditation could ease burden
Approaching the 3-year anniversary of the onset of the COVID-19 pandemic, many can attest to the mental health challenges that came with the sudden changes to everyday life as the disease took hold. In schools, teachers and support staff were forced to revamp lesson plans for virtual and hybrid learning environments, all while toggling between remote and in-person duties and supervising at-home learning.

Health - Life Sciences - 19.01.2023
New nanoparticles deliver therapy brain-wide, edit Alzheimer's gene in mice
New nanoparticles deliver therapy brain-wide, edit Alzheimer’s gene in mice
Gene therapies have the potential to treat neurological disorders like Alzheimer's and Parkinson's diseases, but they face a common barrier - the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain's protective membrane to deliver brain-wide therapy with a range of biological medications and treatments.

Paleontology - Health - 18.01.2023
Traces of a trauma 245 million years ago
Traces of a trauma 245 million years ago
Researchers gain insight into life in an ancient sea With a broken jaw on the prowl - that seems almost impossible. But researchers have discovered an approximately 245-million-year-old nothosaur fossil on which the injury had healed. The international team, with participation from the University of Bonn, examined other marine reptile bone anomalies from a site near the town of Winterswijk in the Netherlands.

Health - Life Sciences - 18.01.2023
Alterations in mitochondrial dynamics lead to inflammation and muscle atrophy
Alterations in mitochondrial dynamics lead to inflammation and muscle atrophy
Recerca Mitochondria —the energy powerhouses of cells— play an essential role in cell physiology. The joining of two or more mitochondria and the division of a mitochondrion into two units are common processes. They are known as mitochondrial dynamics and are necessary for the proper functioning of these structures and of the cell itself.

Health - Life Sciences - 18.01.2023
Covid-19: genetic defects responsible for multisystemic inflammatory syndrome in children
The team from the Human Genetics of Infectious Diseases Laboratory of the Necker-Enfants malades AP-HP Hospital, Inserm, Université Paris Cité within the Imagine Institute, leading the international consortium COVID Human Genetic Effort ( www.covidhge.com ) coordinated by Prof. Jean-Laurent Casanova and Prof. Laurent Abel, has discovered genetic defects responsible for multi-systemic inflammatory syndrome in children (MIS-C), following infection with SARS-CoV-2.

Health - Life Sciences - 18.01.2023
Scientists developing early Alzheimer’s disease detection sensor
By Melissa Shaw Researchers with the SFU Nanodevice Fabrication Group are developing a new biosensor that can be used to screen for Alzheimer's disease and other diseases. An overview of their work has been recently published in the journal Nature Communications. Their sensor works by detecting a particular type of small protein, in this case a cytokine known as Tumour Necrosis Factor alpha (TNF alpha), which is involved with inflammation in the body.

Health - Life Sciences - 18.01.2023
Researchers create anti-COVID cleaning spray
Researchers create anti-COVID cleaning spray
VNR is available via Dropbox . University of Queensland researchers have developed a long lasting surface spray that has the potential to kill viruses such as COVID-19 and potentially deadly bacteria. The spray contains a protein that allows it to stick to surfaces and remain effective for 24 hours and is being assessed by the Therapeutic Goods Administration for commercial cleaning use.

Health - Life Sciences - 18.01.2023
How SARS-CoV-2 evolved to counter its own weaknesses
How SARS-CoV-2 evolved to counter its own weaknesses
Johns Hopkins researchers say their research can improve our understanding of how the spike protein works and how the virus evolves, aiding vaccine design and increasing knowledge about COVID-19 antibodies Researchers at Johns Hopkins Medicine say their new studies suggest that the first pandemic-accelerating mutation in the SARS-CoV-2 virus, which causes COVID-19, evolved as a way to correct vulnerabilities caused by the mutation that started the SARS-CoV-2 pandemic.

Life Sciences - Health - 18.01.2023
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
"Single-cell profiling" is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways. Close After decades of fundamental scientific and drug discovery research, Alzheimer's disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress.

Health - Agronomy / Food Science - 17.01.2023
Dietary Exposure to Nitrites Associated with Increased Type 2 Diabetes Risk
More than 15,000 packaged products on the French market currently contain nitrites or nitrates. Although commonly used to ensure better preservation of processed meats (ham, sausages, etc.), the safety of these food additives is the subject of debate. Nitrites and nitrates are also naturally found in various foods (particularly vegetables) and in drinking water, but agricultural and industrial practices can increase their levels.