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Life Sciences - Pharmacology - 19.10.2021
Largest ever global study of tuberculosis identifies genetic causes of drug resistance
Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance Prediction for Tuberculosis International Consortium (CRyPTIC) research project has collected the largest ever global dataset of clinical M. tuberculosis samples from across the world consisting of 15,211 samples from 27 countries on five continents.

Health - Pharmacology - 19.10.2021
Cell fitness used to determine outcomes in COVID patients
Cell fitness has been identified as a way of predicting health outcomes in COVID patients, according to a University of Queensland study. The study investigated a cellular fitness marker, known as hfwe-Lose, to identify sub-optimal cells in patients who had been hospitalised or died from COVID at the start of the pandemic.

Health - Pharmacology - 14.10.2021
Help for the weakened heart
Help for the weakened heart
MHH research team demonstrates how inflammatory cells improve the function of diseased heart muscle cells Heart failure or cardiac insufficiency is one of the most common causes of death in Germany and is caused by heart attacks, high blood pressure or heart valve defects. The heart is then no longer able to pump a sufficient amount of blood through the body and supply organs, muscles or other tissues with enough oxygen and nutrients.

Pharmacology - 14.10.2021
New proteins enable scientists to control cell activities
New proteins enable scientists to control cell activities
Scientists have developed new controlled proteins and used to switch cellular activities on and off like a light bulb. Sailan Shui, a doctoral assistant at EPFL's Laboratory of Protein Design and Immunoengineering, enjoys playing with proteins, activating and deactivating them as she wishes, as if light switches that can be turned on and off.

Health - Pharmacology - 14.10.2021
Why Sydney's COVID numbers didn't get as bad as the modelling suggested
Why Sydney’s COVID numbers didn’t get as bad as the modelling suggested
COVID-19 case numbers and hospitalisations in NSW are better than expected. Professor Jamie Triccas and Dr Megan Steain propose two key factors that could account for this: vaccine effectiveness and real-time protection. Last Monday, Sydney emerged from a lockdown of more than 100 days after reaching the milestone of having 70 percent of the over-16 population fully vaccinated.

Health - Pharmacology - 13.10.2021
Tackling the collateral damage from antibiotics
Tackling the collateral damage from antibiotics
Antibiotics help us to treat bacterial infections and save millions of lives each year. But they can also harm the helpful microbes residing in our gut, weakening one of our body's first lines of defence against pathogens and compromising the multiple beneficial effects our microbiota has for our health.

Health - Pharmacology - 13.10.2021
Study challenges popular jaw surgery technique
Study challenges popular jaw surgery technique
The study set out to investigate the best way of repairing the most common subtype of lower jaw fracture - angle fractures - as unsuccessful jaw trauma and repair can result in serious short and long-term problems for the patient and are a major cause of morbidity, costing millions in hospitalisation annually.

Health - Pharmacology - 12.10.2021
Highly potent antibody against SARS-CoV-2
Highly potent antibody against SARS-CoV-2
Scientists at Lausanne University Hospital (CHUV) and EPFL have discovered a highly potent monoclonal antibody that targets the SARS-CoV-2 spike protein and is effective at neutralizing all variants of concern identified to date, including the delta variant. Their findings are published in the prestigious journal Cell Reports.

Health - Pharmacology - 11.10.2021
Vaccines effective against most SARS-CoV-2 variants
Two of the commonly used coronavirus vaccines provide protection against multiple variants of the virus that causes COVID-19, including the highly infectious Delta variant, a new Yale study has found. The findings, published Oct. 11 , also show that those infected with the virus prior to vaccination exhibit a more robust immune response to all variants than those who were uninfected and fully vaccinated.

Health - Pharmacology - 07.10.2021
Financial rewards lead to higher vaccination uptake
Modest financial rewards can help increase COVID-19 vaccination rates. This is the conclusion of an international study co-lead by Swiss universities, based on data from Sweden. Despite countless appeals from politicians and scientists, stagnating vaccination rates hamper the containment of coronavirus.

Health - Pharmacology - 06.10.2021
Implantable tech could be a game-changer for heart patients
Implantable heart technology is being used in Manchester to assess when a patient is at high risk of dying, thanks to University of Manchester and Manchester University NHS Foundation Trust -led research. The implantable pacemakers and defibrillators contain multiple sensors that allow continuous monitoring of a patient's heart health, 24 hours a day.

Health - Pharmacology - 06.10.2021
KU Leuven develops very potent antiviral against dengue
KU Leuven develops very potent antiviral against dengue
Researchers at the KU Leuven Rega Institute and CD3 have developed an ultrapotent inhibitor of the dengue virus, which causes the tropical disease known as dengue.

Health - Pharmacology - 06.10.2021
Video games can have similar health benefits to jogging
Video games can have similar health benefits to jogging
Active video games could be a motivating way for Type 1 diabetics to keep active and help manage their condition. Last updated on Wednesday 6 October 2021 Active video games have similar positive health effects on the body as traditional exercises, such as jogging on a treadmill, according to a new study.

Pharmacology - Health - 05.10.2021
Campaign could reduce risk of UK opioid ’epidemic’
A campaign that urged GPs to 'think-twice' before putting a patient on opioid medicines is effective in reducing opioid prescribing in primary care, according to the findings of a major study by researchers from the University of Leeds, the University of Manchester and NHS Bradford Districts Clinical Commissioning Group, West Yorkshire.

Health - Pharmacology - 05.10.2021
'Mother of all cannabinoids': anti-seizure compounds found in cannabis
’Mother of all cannabinoids’: anti-seizure compounds found in cannabis
The team at the Lambert Initiative for Cannabinoid Therapeutics is focused on developing a better cannabis-based treatment for Dravet syndrome, an intractable form of childhood epilepsy. Research from pharmacologists at the University of Sydney provides new insights into how cannabis extracts may work to treat epilepsy.

Health - Pharmacology - 05.10.2021
MRNA COVID vaccines highly effective at preventing symptomatic infection in health workers
COVID-19 are highly effective in preventing symptomatic illness among health care workers in real-world settings. The study, published in the New England Journal of Medicine, found that health care personnel who received a two-dose regimen of Pfizer-BioNTech vaccine had an 89% lower risk for symptomatic illness than those who were unvaccinated.

Pharmacology - Psychology - 05.10.2021
New study to look at TMS treatment for OCD
OCD can have a profound effect on a person's life with psychological therapy, self-help techniques, and medication the current treatment options, although these are ineffective in many patients. Using a form of TMS, a non-invasive brain stimulation treatment that can change brain activity, researchers will use Theta-burst stimulation (TBS) to try to normalise brain activity in OCD patients.

Pharmacology - Life Sciences - 01.10.2021
A tool to interrogate a new class of drugs
Reactive electrophilic drugs like Tecfidera, approved for the treatment of relapsing multiple sclerosis, show a lot of potential but are also mystery. Their effects are notoriously difficult to study, which hampers progress testing and approving them. scientists have now used an innovative chemical method to uncover the biological mechanisms of Tecfidera, providing a powerful tool for exploring other reactive electrophilic drugs.

Pharmacology - Health - 30.09.2021
Staying on long-term antidepressants reduces risk of relapse
When people stop taking antidepressants after a long period of use, just over half (56%) experience a relapse within a year, compared to 39% of those who stay on medication, finds a new study led by UCL researchers. The researchers say their findings, published in The New England Journal of Medicine , can help doctors and patients to make an informed decision together on whether or not to stop their antidepressants after recovery from a depressive episode.

Life Sciences - Pharmacology - 30.09.2021
Relieving pain by mapping its biological signatures
Relieving pain by mapping its biological signatures
Researchers at the University of Geneva and the Clinique romande de réadaptation in Sion have mapped the biomarkers of different types of pain to categorise and better treat them in the future. Many people are confronted with chronic pain that can last for months or even years. How to best treat chronic pain? First, pain must be categorized for the right treatment to be prescribed.
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