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Pharmacology - Health - 05.12.2019
Pharmacology - Health - 04.12.2019 
Typhoid vaccine over 81% effective in tackling disease in Nepal
A large field study of typhoid conjugate vaccine (TCV) in Nepal has shown a single dose to be safe and effective in reducing typhoid in children aged 9 months to <16 years in an endemic setting. Caused by the bacterium Salmonella Typhi, typhoid is a major cause of fever in children in lowand middle-income countries and is responsible for nearly 11 million cases and more than 116,000 deaths a year worldwide.
Life Sciences - Pharmacology - 04.12.2019
Pharmacology - Psychology - 03.12.2019
Pharmacology - Health - 03.12.2019
Chemistry - Pharmacology - 03.12.2019 
Two chiral catalysts working hand in hand
Chemists at Münster University develop a synthetic method providing access to different stereoisomers of a molecule / Study published in 'Nature Catalysis' Just as our left hand is not superposable to our right hand, the mirror image of certain molecules cannot be overlapped onto it, even when turned or twisted.
Health - Pharmacology - 03.12.2019
Pharmacology - Health - 02.12.2019 
Face mask can help combat mild cases of sleep condition
A night time face mask can improve energy levels and vitality in people who suffer from the condition sleep apnoea. This is the finding from a new study of over 200 patients, published in the journal The Lancet Respiratory Medicine , led by Imperial College London. We are seeing increasing cases of sleep apnoea, and in a wide range of patients.
Life Sciences - Pharmacology - 02.12.2019 
Designing and re-purposing cell receptors
EPFL scientists have developed a computational method modeling and designing protein allostery that allows the accurate and rational engineering and even re-purposing of cell receptors. The method can be a significant tool for drug development. Called the "second secret of life", allostery is one of the most fundamental processes of biology and has been a central focus among scientists across the life sciences spectrum, from fundamental biology to drug development.
Health - Pharmacology - 02.12.2019 
Big Data makes intensive care better
Patient safety in intensive care units could be significantly improved if false alarms could be greatly reduced and critical complications such as epileptic seizures could be predicted. This is where the "ICU Cockpit" project of the National Research Programme "Big Data" (NRP 75) comes in: The large amounts of data from intensive care medicine will be used to develop procedures for early warning systems and therapeutic recommendations.
Pharmacology - Health - 02.12.2019
Pharmacology - Health - 28.11.2019
Pharmacology - Health - 26.11.2019
Pharmacology - Health - 26.11.2019
Health - Pharmacology - 26.11.2019 
One third of UK doctors may suffer from workplace ’burnout’
One in three UK doctors working in obstetrics and gynaecology may suffer from workplace burnout. This could affect their well-being and how they treat patients. This is the finding of new research, published in the journal BMJ Open , led by scientists at Imperial College London.
Pharmacology - 22.11.2019 
New model for predicting kidney injury after common heart procedure
A Yale-led group of doctors has developed a new mathematical model that can predict the risk of acute kidney injury (AKI) in patients undergoing a common heart procedure. For patients treated with percutaneous coronary intervention (PCI), commonly known as angioplasty, exposure to contrast agents - material used in the procedure to help visualize blood vessels - can harm the kidneys.
Pharmacology - 21.11.2019 
Potential new treatment for rare muscle-wasting disease
A team of Cardiff University researchers has uncovered a potential new way to treat a very rare genetic disorder that causes muscles in the arms and legs to become increasingly weak. GNE myopathy is a debilitating condition that affects young adults in their 20s or 30s, typically leaving them in a wheelchair within years.
Pharmacology - Health - 21.11.2019
Health - Pharmacology - 20.11.2019
Health - Pharmacology - 20.11.2019 
Digital sepsis monitoring system helps save lives and improves care
The introduction of a digital alert system to monitor patients with sepsis has led to a reduction in deaths and hospital stays. Sepsis, also known as blood poisoning, is life threatening and accounts for an estimated 46,000 deaths in the UK each year. If diagnosed early it can be treated effectively with antibiotics but the difficulty lies in spotting sepsis before it develops, as symptoms are similar to other illnesses such as flu.
Pharmacology
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Reveals dramatic rise in patients ’cured’ of heart condition following GP performance pay scheme
The introduction of a performance-related financial incentive scheme for GPs led to a dramatic almost five-fold rise in the number of patients whose heart rhythm condition was said to have been ‘cured', say University of Birmingham researchers. Academics at the University of Birmingham's Institute of Applied Health Research, supported by NIHR ARC West Midlands, conducted a study into patients with the most common heart rhythm condition, called atrial fibrillation.
The introduction of a performance-related financial incentive scheme for GPs led to a dramatic almost five-fold rise in the number of patients whose heart rhythm condition was said to have been ‘cured', say University of Birmingham researchers. Academics at the University of Birmingham's Institute of Applied Health Research, supported by NIHR ARC West Midlands, conducted a study into patients with the most common heart rhythm condition, called atrial fibrillation.
A large field study of typhoid conjugate vaccine (TCV) in Nepal has shown a single dose to be safe and effective in reducing typhoid in children aged 9 months to <16 years in an endemic setting. Caused by the bacterium Salmonella Typhi, typhoid is a major cause of fever in children in lowand middle-income countries and is responsible for nearly 11 million cases and more than 116,000 deaths a year worldwide.
Drugs that quell brain inflammation reverse dementia
UC Berkeley scientists propose a radical new theory that the memory loss and cognitive dysfunction of aging is due to a leaky barrier between the blood stream and the brain. (iStock image) Drugs that tamp down inflammation in the brain could slow or even reverse the cognitive decline that comes with age.
UC Berkeley scientists propose a radical new theory that the memory loss and cognitive dysfunction of aging is due to a leaky barrier between the blood stream and the brain. (iStock image) Drugs that tamp down inflammation in the brain could slow or even reverse the cognitive decline that comes with age.
Chronic opioid treatment may raise risk of post-traumatic stress disorder
While opioids are often prescribed to treat people with trauma-related pain, a new UCLA-led study suggests doctors should use caution before prescribing the drug to those they believe may experience severe stress in the future, in order to reduce the risk the patient will develop PTSD. In the study, researchers administered doses of the opioid morphine to a group of 22 mice for one week, then gave the mice relatively strong foot shocks.
While opioids are often prescribed to treat people with trauma-related pain, a new UCLA-led study suggests doctors should use caution before prescribing the drug to those they believe may experience severe stress in the future, in order to reduce the risk the patient will develop PTSD. In the study, researchers administered doses of the opioid morphine to a group of 22 mice for one week, then gave the mice relatively strong foot shocks.
One dose of radiotherapy as effective as five doses for cancer in the spine
A single dose of radiotherapy is as "effective" as five doses for end-of-life cancer patients suffering with painful spinal canal compression, finds a large study conducted by UCL. Spinal canal compression is a common complication in cancer patients when the cancer has spread to their spine. Radiotherapy is used to control pain and alleviate symptoms.
A single dose of radiotherapy is as "effective" as five doses for end-of-life cancer patients suffering with painful spinal canal compression, finds a large study conducted by UCL. Spinal canal compression is a common complication in cancer patients when the cancer has spread to their spine. Radiotherapy is used to control pain and alleviate symptoms.
Chemists at Münster University develop a synthetic method providing access to different stereoisomers of a molecule / Study published in 'Nature Catalysis' Just as our left hand is not superposable to our right hand, the mirror image of certain molecules cannot be overlapped onto it, even when turned or twisted.
Shows why visceral fat increases with age and impairs metabolism
Aging is associated with increased inflammation and metabolic disease, including the accumulation of visceral fat - fat stored in the abdominal cavity - which is thought to contribute to inflammation. New research from University of Minnesota faculty member Christina Camell has helped uncover why visceral fat increases with age and points to new treatment possibilities for improving metabolic health.
Aging is associated with increased inflammation and metabolic disease, including the accumulation of visceral fat - fat stored in the abdominal cavity - which is thought to contribute to inflammation. New research from University of Minnesota faculty member Christina Camell has helped uncover why visceral fat increases with age and points to new treatment possibilities for improving metabolic health.
A night time face mask can improve energy levels and vitality in people who suffer from the condition sleep apnoea. This is the finding from a new study of over 200 patients, published in the journal The Lancet Respiratory Medicine , led by Imperial College London. We are seeing increasing cases of sleep apnoea, and in a wide range of patients.
EPFL scientists have developed a computational method modeling and designing protein allostery that allows the accurate and rational engineering and even re-purposing of cell receptors. The method can be a significant tool for drug development. Called the "second secret of life", allostery is one of the most fundamental processes of biology and has been a central focus among scientists across the life sciences spectrum, from fundamental biology to drug development.
Patient safety in intensive care units could be significantly improved if false alarms could be greatly reduced and critical complications such as epileptic seizures could be predicted. This is where the "ICU Cockpit" project of the National Research Programme "Big Data" (NRP 75) comes in: The large amounts of data from intensive care medicine will be used to develop procedures for early warning systems and therapeutic recommendations.
Placebo use among Australian GPs surprisingly high
Most Australian GPs have used a placebo in practice at least once, with active placebos (active treatments used primarily to generate positive expectations) more commonly used than inert placebos, according to a new study in Psychology. Placebo use by GPs high International studies indicate that placebo use by general practitioners (GPs) is remarkably high, but until now usage in Australia was unknown.
Most Australian GPs have used a placebo in practice at least once, with active placebos (active treatments used primarily to generate positive expectations) more commonly used than inert placebos, according to a new study in Psychology. Placebo use by GPs high International studies indicate that placebo use by general practitioners (GPs) is remarkably high, but until now usage in Australia was unknown.
Pharmacist-led interventions may help prevent cardiovascular disease
Pharmacists based in GP practices can play an integral role in the prevention of cardiovascular disease, finds new research led by the University of Birmingham. The study findings, published today in the British Journal of Clinical Pharmacology , support the involvement of pharmacists as healthcare providers in managing patients with hypertension, diabetes and high cholesterol.
Pharmacists based in GP practices can play an integral role in the prevention of cardiovascular disease, finds new research led by the University of Birmingham. The study findings, published today in the British Journal of Clinical Pharmacology , support the involvement of pharmacists as healthcare providers in managing patients with hypertension, diabetes and high cholesterol.
Doctors should avoid co-prescribing benzodiazepines to opioid dependent patients due to increase in overdose death
Doctors should avoid co-prescribing benzodiazepines to opioid dependent patients who are being treated with methadone or buprenorphine, also known as opioid agonist treatment (OAT), due to a three-fold increase in risk of overdose death, according to a study led by researchers at the University of Bristol.
Doctors should avoid co-prescribing benzodiazepines to opioid dependent patients who are being treated with methadone or buprenorphine, also known as opioid agonist treatment (OAT), due to a three-fold increase in risk of overdose death, according to a study led by researchers at the University of Bristol.
One shot of ketamine could reduce problem drinking
A one-off dose of ketamine could help heavy drinkers reduce their alcohol intake, finds a new UCL experimental study. Giving a shot of ketamine to heavy drinkers after reactivating their drinking-related memories led to a rapid decrease in urges to drink and a prolonged decrease in alcohol intake over nine months, according to the study published .
A one-off dose of ketamine could help heavy drinkers reduce their alcohol intake, finds a new UCL experimental study. Giving a shot of ketamine to heavy drinkers after reactivating their drinking-related memories led to a rapid decrease in urges to drink and a prolonged decrease in alcohol intake over nine months, according to the study published .
One in three UK doctors working in obstetrics and gynaecology may suffer from workplace burnout. This could affect their well-being and how they treat patients. This is the finding of new research, published in the journal BMJ Open , led by scientists at Imperial College London.
A Yale-led group of doctors has developed a new mathematical model that can predict the risk of acute kidney injury (AKI) in patients undergoing a common heart procedure. For patients treated with percutaneous coronary intervention (PCI), commonly known as angioplasty, exposure to contrast agents - material used in the procedure to help visualize blood vessels - can harm the kidneys.
A team of Cardiff University researchers has uncovered a potential new way to treat a very rare genetic disorder that causes muscles in the arms and legs to become increasingly weak. GNE myopathy is a debilitating condition that affects young adults in their 20s or 30s, typically leaving them in a wheelchair within years.
Small rise in heart attack protein linked to increased risk of early death
An analysis of patients' heart data has shown that even a small increase in a protein linked to heart attacks is linked to an increased risk of death. Clinicians use troponin testing, alongside other investigations, to determine whether a patient is having a heart attack and to inform treatment choices.
An analysis of patients' heart data has shown that even a small increase in a protein linked to heart attacks is linked to an increased risk of death. Clinicians use troponin testing, alongside other investigations, to determine whether a patient is having a heart attack and to inform treatment choices.
New maths reveals how diseases progress and bacteria develop drug resistance
Scientists from Imperial and the University of Bergen have found a new way to predict how a disease will likely progress in individual patients. This could help patients receive more targeted treatments earlier in the progress of their disease. [Our approach] is very useful for tracking disease markers, learning about biological evolution and other processes that occur over time.
Scientists from Imperial and the University of Bergen have found a new way to predict how a disease will likely progress in individual patients. This could help patients receive more targeted treatments earlier in the progress of their disease. [Our approach] is very useful for tracking disease markers, learning about biological evolution and other processes that occur over time.
The introduction of a digital alert system to monitor patients with sepsis has led to a reduction in deaths and hospital stays. Sepsis, also known as blood poisoning, is life threatening and accounts for an estimated 46,000 deaths in the UK each year. If diagnosed early it can be treated effectively with antibiotics but the difficulty lies in spotting sepsis before it develops, as symptoms are similar to other illnesses such as flu.
