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Pharmacology - Health - 24.06.2019
New Therapy Promotes Vascular Repair Following Stroke
New Therapy Promotes Vascular Repair Following Stroke
Following a stroke, antibodies that inhibit the signaling molecule Nogo-A can help repair blood vessels in the affected brain regions. This also promotes the regaining of motor functions, researchers at the University of Zurich have shown in a mouse model. The study opens up new avenues for treatment.

Pharmacology - 20.06.2019
Connecting the dots: nitrogen dioxide over Siberian pipelines
Connecting the dots: nitrogen dioxide over Siberian pipelines
New maps that use information from the Copernicus Sentinel-5P satellite reveal emissions of nitrogen dioxide along a Siberian natural gas pipeline that connects the Urengoy gas field - the second-largest gas field in the world - with Europe. The Urengoy-Pomary-Uzhhorod pipeline is one of Russia's main natural gas export pipelines.

Health - Pharmacology - 19.06.2019
Federal guidelines may restrict women’s access to effective HIV protection
Restrictive recommendations for pre-exposure prophylaxis (or PrEP) issued by the Centers for Disease Control and Prevention (CDC) systematically disqualified nearly all women at risk for HIV and/or motivated to use the medication, researchers at the Yale School of Public Health and George Washington University have found.

Pharmacology - Life Sciences - 17.06.2019
Preventing drugs from being transported
Certain membrane proteins specialise in transporting molecules out of cells - a problem for the efficacy of cancer medication and antibiotics. An international research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment. The transport proteins, called ABC exporters, are present, for instance, in the cell membranes of bacteria and in large quantities in cancer cells and are responsible for transporting small molecules out of the cells.

Pharmacology - Health - 14.06.2019
Compound with anti-aging effects passes human trial
Compound with anti-aging effects passes human trial
Urolithin A, a metabolite of biomolecules found in pomegranates and other fruits, could help slow certain aging processes. EPFL spin-off Amazentis, in conjunction with EPFL and the Swiss Institute of Bioinformatics, has published a paper Metabolism outlining the results of their clinical trial. It is a fact of life that skeletal muscles begin to lose strength and mass once a person reaches the age of 50.

Pharmacology - Health - 14.06.2019
New drug target for liver disease treatment
New drug target for liver disease treatment
A possible drug target for chronic liver disease has been identified by an international research collaboration involving a University of Queensland team. Professor Matt Sweet and Dr Divya Ramnath from UQ's Institute for Molecular Bioscience (IMB) worked with the study's senior author Dr Ekihiro Seki from Cedars-Sinai in Los Angeles, to identify genes linked to the progression of chronic liver disease.

Life Sciences - Pharmacology - 13.06.2019
GlaxoSmithKline taps UC’s CRISPR expertise to speed drug discovery
Jennifer Doudna and Jonathan Weissman are the key players in a new collaboration with GlaxoSmithKline to apply CRISPR techniques to the discovery of new drug targets, potentially leading to new therapies for genetic diseases.

Health - Pharmacology - 12.06.2019
Immunotherapy drug shows potential to cure advanced lung cancer
In a new study including Yale Cancer Center and Smilow Cancer Hospital researchers, the cancer immunotherapy drug pembrolizumab (Keytruda), increased survival for patients with advanced non-small cell lung cancer (NSCLC), a disease once considered an aggressive, and uniformly fatal cancer. The findings were presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago.

Pharmacology - Health - 12.06.2019
New vulnerability found in viruses may help develop cure for the common cold
A team of researchers led by KU Leuven virologist Johan Neyts have discovered a new feature of so-called picornaviruses that may allow for the development of new antiviral medications for the common cold, polio, and other illnesses. Picornaviruses include rhinoviruses and enteroviruses. Rhinoviruses cause millions of cases of upper respiratory infections ("colds") yearly and contribute to asthma, and enteroviruses are responsible for millions of infections including cases such as meningitis, encephalitis and polio.

Pharmacology - Chemistry - 11.06.2019
Learning from Nature's Bounty: New Libraries for Drug discovery
Learning from Nature’s Bounty: New Libraries for Drug discovery
Natural products, or their close derivatives, make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. The size and complexity of macrocycles has made it difficult to emulate and build on Nature's success in the laboratory.

Health - Pharmacology - 11.06.2019
Peptides that mimic ’good cholesterol’ reverse inflammatory bowel disease in mice
FINDINGS Peptides that mimic the function of HDL cholesterol, which has been dubbed “good cholesterol,” can treat the underlying inflammation associated with inflammatory bowel disease, or IBD, according to new research in mice. The same work revealed new details on how IBD can develop and what other types of drugs may work to treat the disease.

Health - Pharmacology - 11.06.2019
Are pharma payments to nurses impacting your healthcare?
Are pharma payments to nurses impacting your healthcare?
New analysis reveals pharmaceutical industry payments to Australian non-prescribing healthcare professionals such as nurses and pharmacists are substantial, raising questions around influence and a call for greater transparency. There's growing awareness that payments by the pharmaceutical industry to doctors - including the provision of even a modest meal at company-hosted events - are associated with poorer quality prescribing behaviour and increased healthcare costs.

Pharmacology - Chemistry - 10.06.2019
Healing compounds in scorpion venom
Stanford chemists have identified and synthesized two new healing compounds in scorpion venom that are effective at killing staph and tuberculosis bacteria. A scorpion native to Eastern Mexico may have more than just toxin in its sting. Researchers at Stanford University and in Mexico have found that the venom also contains two color-changing compounds that could help fight bacterial infections.

Health - Pharmacology - 10.06.2019
Vitamin D and colorectal cancer survival
Vitamin D, the "sunshine vitamin," may be helpful for people diagnosed with colon cancer, says   Charles Fuchs, MD, MPH , director of Yale Cancer Center. A small clinical trial, called the "Sunshine Trial," found the odds of dying from colon cancer were lower for those with high levels of vitamin D in their bloodstream than for those whose blood contained lower levels.

Health - Pharmacology - 10.06.2019
Improving breast cancer treatment
Millions of patients with incurable breast cancer could benefit from Welsh-led research which shows it is possible to control the cancer for twice as long by combing an investigational therapy with standard treatment. Oestrogen receptive positive breast cancer can be treated by drugs, such as fulvestrant, that interfere with the action of oestrogen.

Health - Pharmacology - 09.06.2019
Immunotherapy delays type 1 diabetes in people at high risk
A drug that targets the immune system can delay the onset of type 1 diabetes in people at high risk of developing the disease, said a Yale investigator who led the National Institutes of Health-funded Diabetes TrialNet study. The research is the first to show that the progression of type 1 diabetes can be slowed by two or more years with immunotherapy.

Pharmacology - Health - 06.06.2019
Three-drug combination helps curb the growth of deadly type of skin cancer
A UCLA-led research team has pinpointed a three-drug combination that could prove to be an effective new therapy for people with a specific type of advanced melanoma. The approach shows promise for extending the lives of people with a type of melanoma that contains a potent gene mutation, BRAF V600E.

Health - Pharmacology - 05.06.2019
TAVR is helping people avoid open heart surgery
There was big news on Twitter this spring. The Rolling Stones tweeted that Mick Jagger, who is 75 and had been diagnosed with a heart problem, underwent a procedure and was expected to be back on the stage as soon as possible. His timing was spot on. Jagger had been diagnosed with aortic stenosis, a narrowing of his aortic valve.

Pharmacology - Health - 04.06.2019
Beta blockers reduce stress-induced irregular heart rhythm
Taking beta blockers - medications that reduce blood pressure and treat many heart conditions - can blunt the negative effects of stress and anger on people with a history of atrial fibrillation, or irregular heart rhythm, said Yale researchers. This strategy could potentially improve quality of life for many of the two million Americans with the condition, according to a new study.

Pharmacology - Health - 03.06.2019
Role of bacteria in drug response
Yale researchers identified human gut microbes that metabolize over 150 therapeutic drugs, a finding that highlights the role bacteria play in determining how well individuals respond to medications, they report June 3 . Scientists in the lab of senior author Andrew Goodman of Yale's Microbial Sciences Institute and the Department of Microbial Pathogenesis also pinpointed the microbial genes responsible for many of these drug-metabolizing activities.
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