News in Brief
Transport - Sep 21
Whittle Lab research key for accelerating the development of zero-carbon flight, says Prince of Wales
Whittle Lab research key for accelerating the development of zero-carbon flight, says Prince of Wales
Life Sciences - Sep 21
Discovery of a druggable pocket in the SARS-CoV-2 Spike protein could stop virus in its tracks
Discovery of a druggable pocket in the SARS-CoV-2 Spike protein could stop virus in its tracks
Health - Sep 21
As nation mourns Ruth Bader Ginsburg, a look at advances in pancreatic cancer treatment
As nation mourns Ruth Bader Ginsburg, a look at advances in pancreatic cancer treatment
Career - Sep 21
Lockdown could have lasting effect on survivors of sexual violence and the services that support them, experts argue
Lockdown could have lasting effect on survivors of sexual violence and the services that support them, experts argue
Economics - Sep 21
Oakland County’s economy hit during pandemic, but it’s well-positioned for recovery
Oakland County’s economy hit during pandemic, but it’s well-positioned for recovery
Health - Sep 21
Novartis Kisqali receives the highest rating of any CDK4/6 inhibitor on the ESMO Magnitude of Clinical Benefit Scale
Novartis Kisqali receives the highest rating of any CDK4/6 inhibitor on the ESMO Magnitude of Clinical Benefit Scale
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Pharmacology - 21.09.2020 
An acoustically actuated microscopic device
Researchers at EPFL have developed remote-controlled, mechanical microdevices that, when inserted into human tissue, can manipulate the fluid that surrounds them, collect cells or release drugs. This breakthrough offers numerous potential applications in the biomedical field, from diagnostics to therapy.
Health - Pharmacology - 21.09.2020
Health - Pharmacology - 18.09.2020
Health - Pharmacology - 15.09.2020 
Only One Third of Children Receive Appropriate Malaria Care
Despite lots of progress made in the past decade, more than 270,000 children die from Malaria each year. Most of these deaths could be avoided through timely diagnosis and treatment. Despite better availability of tests and medication, a new study shows that large gaps remain in the quality of malaria care for children.
Pharmacology - Health - 14.09.2020
Health - Pharmacology - 14.09.2020
Social Sciences - Pharmacology - 14.09.2020
Health - Pharmacology - 10.09.2020 
Punctured lung affects almost one in a hundred hospitalised COVID-19 patients
As many as one in 100 patients admitted to hospital with COVID-19 develop a pneumothorax - a 'punctured lung' - according to a study led by Cambridge researchers. Doctors need to be alert to the possibility of a punctured lung in patients with COVID-19, even in people who would not be thought to be typical at-risk patients Stefan Marciniak Like the inner tube of bicycle or car tyre, damage to the lungs can lead to a puncture.
Health - Pharmacology - 10.09.2020
Health - Pharmacology - 09.09.2020
Health - Pharmacology - 09.09.2020
Health - Pharmacology - 08.09.2020
Health - Pharmacology - 08.09.2020
Pharmacology - Health - 07.09.2020 
Genetic study of proteins is a breakthrough in drug development for complex diseases
An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. Working in collaboration with pharmaceutical companies, Bristol researchers have developed a comprehensive analysis pipeline using genetic prediction of protein levels to prioritise drug targets, and have quantified the potential of this approach for reducing the failure rate of drug development.
Health - Pharmacology - 05.09.2020 
Scientists create blueprint to vaccinate in Bangladesh and beyond
Scientists will work in Bangladesh to create a blueprint to help ensure that medics can get a COVID-19 vaccine to everyone who needs it across the Global South. Universal vaccine access is already a major challenge in low-income countries, due to the lack of robust refrigerated cooling networks especially to remote communities.
Life Sciences - Pharmacology - 04.09.2020
Health - Pharmacology - 03.09.2020 
Antiretroviral therapy fails to treat one-third of HIV patients in Malawi hospital
Antiretroviral therapy (ART) failure and drug resistance are extremely common in patients living with HIV who are admitted to hospital in Malawi, according to new research published in Lancet HIV .
Life Sciences - Pharmacology - 03.09.2020
Health - Pharmacology - 03.09.2020
Health - Pharmacology - 02.09.2020
Pharmacology
Results 1 - 20 of 1049.
Researchers at EPFL have developed remote-controlled, mechanical microdevices that, when inserted into human tissue, can manipulate the fluid that surrounds them, collect cells or release drugs. This breakthrough offers numerous potential applications in the biomedical field, from diagnostics to therapy.
Giant spider provides promise of pain relief for irritable bowel syndrome
Molecules from the venom of one of the world's largest spiders could help University of Queensland-led researchers tailor pain blockers for people with irritable bowel syndrome (IBS). Researchers screened 28 spiders, with the venom of the Venezuelan Pinkfoot Goliath tarantula - which has a leg-span of up to 30 centimetres - showing the most promise.
Molecules from the venom of one of the world's largest spiders could help University of Queensland-led researchers tailor pain blockers for people with irritable bowel syndrome (IBS). Researchers screened 28 spiders, with the venom of the Venezuelan Pinkfoot Goliath tarantula - which has a leg-span of up to 30 centimetres - showing the most promise.
Increasing the effectiveness of immunotherapy against skin cancer
Researchers at the University of Bern have discovered a mechanism in the body's own immune system which is responsible for the maturing and activation of immune cells. In the fight against skin cancer, the results have the potential to help immunotherapy succeed, even for patients on whom it previously had no effect.
Researchers at the University of Bern have discovered a mechanism in the body's own immune system which is responsible for the maturing and activation of immune cells. In the fight against skin cancer, the results have the potential to help immunotherapy succeed, even for patients on whom it previously had no effect.
Despite lots of progress made in the past decade, more than 270,000 children die from Malaria each year. Most of these deaths could be avoided through timely diagnosis and treatment. Despite better availability of tests and medication, a new study shows that large gaps remain in the quality of malaria care for children.
A simple tweak to increase vaccine protection
Adjuvants are a key ingredient of many modern vaccines, working to unleash an immune response that helps protect the body from disease. Many scientists believe that adjuvants are the key to developing new kinds of vaccines for hard-to-vaccinate viruses, like HIV. But adjuvants can cause inflammation at the injection site, as well as side effects from an over-stimulated immune system, which prohibits many promising new adjuvant candidates from being integrated into vaccines.
Adjuvants are a key ingredient of many modern vaccines, working to unleash an immune response that helps protect the body from disease. Many scientists believe that adjuvants are the key to developing new kinds of vaccines for hard-to-vaccinate viruses, like HIV. But adjuvants can cause inflammation at the injection site, as well as side effects from an over-stimulated immune system, which prohibits many promising new adjuvant candidates from being integrated into vaccines.
New treatments for deadly lung disease could be revealed by 3D modeling
Research shows why pulmonary fibrosis drugs that target lung stiffness alone may not work in patients, even if they show promise in a Petri dish A 3D bioengineered model of lung tissue built by University of Michigan researchers is poking holes in decades worth of flat, Petri dish observations into how the deadly disease pulmonary fibrosis progresses.
Research shows why pulmonary fibrosis drugs that target lung stiffness alone may not work in patients, even if they show promise in a Petri dish A 3D bioengineered model of lung tissue built by University of Michigan researchers is poking holes in decades worth of flat, Petri dish observations into how the deadly disease pulmonary fibrosis progresses.
Dramatic increases in vaping marijuana, nicotine among US college students, young adults
Vaping marijuana and vaping nicotine have increased dramatically among 19-to-22-year-olds, with both more than doubling between 2017 and 2019, according to the University of Michigan's annual U.S. national Monitoring the Future Panel Study. In addition, use of marijuana in any form in 2019 among young adults was at or near the highest levels seen over the past four decades.
Vaping marijuana and vaping nicotine have increased dramatically among 19-to-22-year-olds, with both more than doubling between 2017 and 2019, according to the University of Michigan's annual U.S. national Monitoring the Future Panel Study. In addition, use of marijuana in any form in 2019 among young adults was at or near the highest levels seen over the past four decades.
As many as one in 100 patients admitted to hospital with COVID-19 develop a pneumothorax - a 'punctured lung' - according to a study led by Cambridge researchers. Doctors need to be alert to the possibility of a punctured lung in patients with COVID-19, even in people who would not be thought to be typical at-risk patients Stefan Marciniak Like the inner tube of bicycle or car tyre, damage to the lungs can lead to a puncture.
Discovery of four Covid-19 risk groups helps guide treatment
People who are admitted to hospital with Covid-19 can be divided into four distinct groups, according to data from the world's largest study of patients with the disease. Researchers identified the groups using clinical information and tests carried out upon arrival at hospital to predict the patients' risk of death - ranging from low to very high.
People who are admitted to hospital with Covid-19 can be divided into four distinct groups, according to data from the world's largest study of patients with the disease. Researchers identified the groups using clinical information and tests carried out upon arrival at hospital to predict the patients' risk of death - ranging from low to very high.
For an effective COVID vaccine, look beyond antibodies to T-cells
Depiction of SARS-CoV-2, the coronavirus that causes COVID-19. The spike proteins are in red. (Image courtesy of the Centers for Disease Control and Prevention) Misplaced focus on antibodies Hellerstein points out that antibodies are not the primary protective response to infection by coronaviruses, the family of viruses that includes SARS-CoV-2.
Depiction of SARS-CoV-2, the coronavirus that causes COVID-19. The spike proteins are in red. (Image courtesy of the Centers for Disease Control and Prevention) Misplaced focus on antibodies Hellerstein points out that antibodies are not the primary protective response to infection by coronaviruses, the family of viruses that includes SARS-CoV-2.
Patients set to benefit from new guidelines on Artificial Intelligence health solutions
Patients could benefit from faster and more effective introduction of artificial intelligence (AI) innovations to diagnose and treat disease - thanks to the first international standards for reporting of clinical trials for AI. As evaluation of health interventions involving machine learning or other AI systems moves into clinical trials, an international group has developed guidelines aiming to improve the quality of these studies and ensure that they are reported transparently.
Patients could benefit from faster and more effective introduction of artificial intelligence (AI) innovations to diagnose and treat disease - thanks to the first international standards for reporting of clinical trials for AI. As evaluation of health interventions involving machine learning or other AI systems moves into clinical trials, an international group has developed guidelines aiming to improve the quality of these studies and ensure that they are reported transparently.
Modeling behaviors that spread disease
In a new mathematical model, Stanford researchers have coupled disease dynamics with cultural behaviors harmful to health - such as anti-vaccination sentiment or aversion to mask-wearing - that can spread like pathogens themselves. Whether it's a cough or a handshake, one point of contact by an infected individual may be all it takes to spark an epidemic.
In a new mathematical model, Stanford researchers have coupled disease dynamics with cultural behaviors harmful to health - such as anti-vaccination sentiment or aversion to mask-wearing - that can spread like pathogens themselves. Whether it's a cough or a handshake, one point of contact by an infected individual may be all it takes to spark an epidemic.
Vitamin D deficiency may raise risk of getting COVID-19
In a retrospective study of patients tested for COVID-19, researchers at the University of Chicago Medicine found an association between vitamin D deficiency and the likelihood of becoming infected with the coronavirus. "Vitamin D is important to the function of the immune system and vitamin D supplements have previously been shown to lower the risk of viral respiratory tract infections," said David Meltzer, Chief of Hospital Medicine at UChicago Medicine and lead author of the study.
In a retrospective study of patients tested for COVID-19, researchers at the University of Chicago Medicine found an association between vitamin D deficiency and the likelihood of becoming infected with the coronavirus. "Vitamin D is important to the function of the immune system and vitamin D supplements have previously been shown to lower the risk of viral respiratory tract infections," said David Meltzer, Chief of Hospital Medicine at UChicago Medicine and lead author of the study.
An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. Working in collaboration with pharmaceutical companies, Bristol researchers have developed a comprehensive analysis pipeline using genetic prediction of protein levels to prioritise drug targets, and have quantified the potential of this approach for reducing the failure rate of drug development.
Scientists will work in Bangladesh to create a blueprint to help ensure that medics can get a COVID-19 vaccine to everyone who needs it across the Global South. Universal vaccine access is already a major challenge in low-income countries, due to the lack of robust refrigerated cooling networks especially to remote communities.
Genetic links to drug and alcohol use among young people
Young people who are genetically predisposed to risk-taking, low extraversion and schizophrenia are more likely to use alcohol, cigarettes, cannabis, or other illicit drugs, according to a new UCL-led study. The researchers say that the findings, published in Addiction Biology , are in line with the notion that people who are more vulnerable to psychopathology or certain personality traits are more inclined to try several types of drugs or use them to 'self-medicate'.
Young people who are genetically predisposed to risk-taking, low extraversion and schizophrenia are more likely to use alcohol, cigarettes, cannabis, or other illicit drugs, according to a new UCL-led study. The researchers say that the findings, published in Addiction Biology , are in line with the notion that people who are more vulnerable to psychopathology or certain personality traits are more inclined to try several types of drugs or use them to 'self-medicate'.
Antiretroviral therapy (ART) failure and drug resistance are extremely common in patients living with HIV who are admitted to hospital in Malawi, according to new research published in Lancet HIV .
Cause and possible treatment for Fragile X
Yale scientists have discovered an underlying mechanism for Fragile X syndrome - a leading cause of autism and the primary genetic driver of intellectual disability - as well as a drug that reversed the underlying abnormality and autism-like behaviors in mice. Their research appears in the Sept. 3 edition of the journal Cell.
Yale scientists have discovered an underlying mechanism for Fragile X syndrome - a leading cause of autism and the primary genetic driver of intellectual disability - as well as a drug that reversed the underlying abnormality and autism-like behaviors in mice. Their research appears in the Sept. 3 edition of the journal Cell.
How to Spot Patients Most Likely to Die from Blood Infections
David Gonzalez's “a-ha? moment came when a physician-colleague, George Sakoulas, MD, shared with him one of the biggest problems faced in clinical practice: How long it takes to diagnose a patient. “The faster we know what's going to happen to our patients, the better we can treat them,' said Sakoulas, an infectious disease specialist and associate adjunct professor of pediatrics at University of California San Diego School of Medicine.
David Gonzalez's “a-ha? moment came when a physician-colleague, George Sakoulas, MD, shared with him one of the biggest problems faced in clinical practice: How long it takes to diagnose a patient. “The faster we know what's going to happen to our patients, the better we can treat them,' said Sakoulas, an infectious disease specialist and associate adjunct professor of pediatrics at University of California San Diego School of Medicine.
Analysis of seven trials finds that corticosteroids reduce risk of death by 20 per cent in critically ill COVID-19 patients
Corticosteroids reduce the risk of death among critically ill COVID-19 patients by 20 per cent, an analysis of seven trials published today [2 September] in the Journal of the American Medical Association (JAMA) has found. The results of three of the trials included in the meta-analysis are also published in JAMA today.
Corticosteroids reduce the risk of death among critically ill COVID-19 patients by 20 per cent, an analysis of seven trials published today [2 September] in the Journal of the American Medical Association (JAMA) has found. The results of three of the trials included in the meta-analysis are also published in JAMA today.
News in Brief
Transport - Sep 21
Whittle Lab research key for accelerating the development of zero-carbon flight, says Prince of Wales
Whittle Lab research key for accelerating the development of zero-carbon flight, says Prince of Wales
Life Sciences - Sep 21
Discovery of a druggable pocket in the SARS-CoV-2 Spike protein could stop virus in its tracks
Discovery of a druggable pocket in the SARS-CoV-2 Spike protein could stop virus in its tracks
Health - Sep 21
As nation mourns Ruth Bader Ginsburg, a look at advances in pancreatic cancer treatment
As nation mourns Ruth Bader Ginsburg, a look at advances in pancreatic cancer treatment
Career - Sep 21
Lockdown could have lasting effect on survivors of sexual violence and the services that support them, experts argue
Lockdown could have lasting effect on survivors of sexual violence and the services that support them, experts argue
Economics - Sep 21
Oakland County’s economy hit during pandemic, but it’s well-positioned for recovery
Oakland County’s economy hit during pandemic, but it’s well-positioned for recovery
Health - Sep 21
Novartis Kisqali receives the highest rating of any CDK4/6 inhibitor on the ESMO Magnitude of Clinical Benefit Scale
Novartis Kisqali receives the highest rating of any CDK4/6 inhibitor on the ESMO Magnitude of Clinical Benefit Scale