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Life Sciences - Pharmacology - 21.02.2019 
A missing gene makes a big difference in patients’ recovery from mild stroke
More than 6 million Americans live with disabilities following a stroke. Even mild strokes can leave survivors with arm and leg weakness, poor muscle control and memory lapses that worsen with age. Now UCLA neuroscientists have found that patients born without a gene called CCR5 recover better from mild stroke than patients with the gene.
Health - Pharmacology - 21.02.2019
Pharmacology - Health - 20.02.2019
Pharmacology - Health - 20.02.2019
Health - Pharmacology - 19.02.2019
Health - Pharmacology - 19.02.2019 
World’s first gene therapy operation for common cause of sight loss carried out
Researchers in Oxford have carried out the world's first gene therapy operation to tackle the root cause of age-related macular degeneration (AMD), the UK's most common cause of sight loss. The procedure was carried out at the John Radcliffe Hospital by Professor Robert MacLaren, Professor of Ophthalmology at the University of Oxford, with the support of the NIHR Oxford Biomedical Research Centre in a clinical trial sponsored by Gyroscope Therapeutics, a UK-based company developing genetically-defined therapies for the treatment of eye diseases.
Health - Pharmacology - 15.02.2019
Health - Pharmacology - 15.02.2019 
Artificial intelligence can predict survival of ovarian cancer patients
Researchers have created new machine learning software that can forecast the survival rates and response to treatments of patients with ovarian cancer The artificial intelligence software, created by researchers at Imperial College London and the University of Melbourne , has been able to predict the prognosis of patients with ovarian cancer more accurately than current methods.
Pharmacology - Chemistry - 11.02.2019
Life Sciences - Pharmacology - 11.02.2019
Health - Pharmacology - 11.02.2019 
For recurrent glioblastoma, immunotherapy before surgery appears to help more than afterward
A UCLA-led study suggests that for people with recurrent glioblastoma, administering an immunotherapy drug before surgery is more effective than using the drug afterward. In recent years, immunotherapy drugs, which harness the body's immune system to destroy cancer cells, have been shown to be helpful in treating people with advanced or metastatic cancer.
Pharmacology - Health - 08.02.2019 
Fluconazole Makes Fungi Sexually Active
Under the influence of the drug fluconazole, the fungus Candida albicans can change its mode of reproduction and thus become even more resistant. Scientists at the University of Würzburg report this in the journal mBio. The yeast Candida albicans occurs in most healthy people as a harmless colonizer in the digestive tract.
Health - Pharmacology - 08.02.2019 
Drug-resistant tuberculosis: high mortality rate due to inaccurate tests
Inaccurate tests carried out on tuberculosis patients in developing countries often fail to reliably detect resistance to drugs, leading to incorrect treatment and a higher mortality rate. These are the results of study by an international group of researchers led by a team at the University of Bern published today.
Pharmacology - Health - 07.02.2019 
New pill can deliver insulin
Capsule that releases insulin in the stomach could replace injections for patients with type 2 diabetes. About the size of a blueberry, the capsule contains a small needle made of compressed insulin, which is injected after the capsule reaches the stomach. In tests in animals, the researchers showed that they could deliver enough insulin to lower blood sugar to levels comparable to those produced by injections given through skin.
Health - Pharmacology - 06.02.2019 
Researchers awarded £1.3 million to fight prostate cancer
Prostate Cancer UK has awarded researchers over £1.3 million for three projects that could lead to new treatments for the disease. The Research Innovation Awards is a prestigious scheme aimed at funding the most impactful research in prostate cancer. The number of prostate cancer cases is increasing in the UK - the condition kills over 11,000 men every year - and research is desperately needed to find new ways of tackling the disease.
Health - Pharmacology - 05.02.2019 
Even psychological placebos have an effect
Placebo effects do not only occur in medical treatment - placebos can also work when psychological effects are attributed to them. Psychologists from the University of Basel reported these findings in the journal Scientific Reports, based on three studies with over 400 participants. Psychotherapy and placebos are both psychological interventions that not only have comparable effects, but that are also based on very similar mechanisms.
Life Sciences - Pharmacology - 05.02.2019 
A better way to measure cell survival
New test rapidly evaluates the effect of drugs and potentially toxic compounds on cells. Measuring the toxic effects of chemical compounds on different types of cells is critical for developing cancer drugs, which must be able to kill their target cells. Analyzing cell survival is also an important task in fields such as environmental regulation, to test industrial and agricultural chemicals for possible harmful effects on healthy cells.
Health - Pharmacology - 05.02.2019
Health - Pharmacology - 01.02.2019
Chemistry - Pharmacology - 01.02.2019 
Intuition and failure are valuable ingredients in chemistry
When researchers make a new discovery, they tend to only publish the results of their successful experiments. But just as informative are all the experiments that didn't work - the failed trials and incorrect hypotheses, which can offer important information. A team of EPFL chemists has developed a methodology for collecting those lessons and, crucially, sharing them with other researchers.
Pharmacology
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More than 6 million Americans live with disabilities following a stroke. Even mild strokes can leave survivors with arm and leg weakness, poor muscle control and memory lapses that worsen with age. Now UCLA neuroscientists have found that patients born without a gene called CCR5 recover better from mild stroke than patients with the gene.
New care package can improve treatment of people with acute kidney injury
A large clinical trial involving people with acute kidney injury has found that a new package of interventions can significantly improve the diagnosis and treatment of patients, as well as improving their care experience. Acute kidney injury (AKI) is a sudden or rapid decline in kidney function that can lead to hospital admission, longer hospital stays, increased mortality risk and long-term kidney damage.
A large clinical trial involving people with acute kidney injury has found that a new package of interventions can significantly improve the diagnosis and treatment of patients, as well as improving their care experience. Acute kidney injury (AKI) is a sudden or rapid decline in kidney function that can lead to hospital admission, longer hospital stays, increased mortality risk and long-term kidney damage.
Long-term benefits from intensive therapy in early stages of MS
New findings by researchers at Cardiff University suggest that intensive therapy during the early stages of multiple sclerosis (MS) leads to better long-term outcomes for patients, despite it often being viewed as a riskier option than other first line treatments. Dr Emma Tallantyre, from Cardiff University's Division of Psychological Medicine and Clinical Neurosciences, said: “Over the last 10-20 years we have seen huge advances in the treatment of relapsing-remitting MS, with over 12 licensed medications having been shown to suppress disease activity.
New findings by researchers at Cardiff University suggest that intensive therapy during the early stages of multiple sclerosis (MS) leads to better long-term outcomes for patients, despite it often being viewed as a riskier option than other first line treatments. Dr Emma Tallantyre, from Cardiff University's Division of Psychological Medicine and Clinical Neurosciences, said: “Over the last 10-20 years we have seen huge advances in the treatment of relapsing-remitting MS, with over 12 licensed medications having been shown to suppress disease activity.
New Method Identifies Which Asthma Patients Respond to Systemic Corticosteroids
Computational tool could help relieve suffering for patients not helped by mainline therapy Physicians will be able to predict which of their patients with severe asthma are likely to benefit from treatment with systemic corticosteroids - and which might only suffer their side effects - with help from a dozen clinical variables researchers have identified using machine learning techniques.
Computational tool could help relieve suffering for patients not helped by mainline therapy Physicians will be able to predict which of their patients with severe asthma are likely to benefit from treatment with systemic corticosteroids - and which might only suffer their side effects - with help from a dozen clinical variables researchers have identified using machine learning techniques.
Seeing the unseeable
Researchers at Cardiff University have used x-ray crystallography and computer simulation to get a closer look at how viruses bind cells and cause infection. The new insight could help in the development of drugs and therapies for infections and further advance the exploitation of viruses for medical treatments.
Researchers at Cardiff University have used x-ray crystallography and computer simulation to get a closer look at how viruses bind cells and cause infection. The new insight could help in the development of drugs and therapies for infections and further advance the exploitation of viruses for medical treatments.
Researchers in Oxford have carried out the world's first gene therapy operation to tackle the root cause of age-related macular degeneration (AMD), the UK's most common cause of sight loss. The procedure was carried out at the John Radcliffe Hospital by Professor Robert MacLaren, Professor of Ophthalmology at the University of Oxford, with the support of the NIHR Oxford Biomedical Research Centre in a clinical trial sponsored by Gyroscope Therapeutics, a UK-based company developing genetically-defined therapies for the treatment of eye diseases.
Joshua Wallach: meta-researcher, Beatles fan, pizza connoisseur
Joshua Wallach: Meta-researcher, Beatles fan, pizza connoisseur The Yale School of Public Health proudly welcomes a large number of new tenure track faculty joining us this academic year. These individuals have widely varied interests and excel in research, scholarship, innovation and teaching. They complement and expand the expertise already available at the School of Public Health and will be instrumental in addressing many of the health challenges of the 21 st century.
Joshua Wallach: Meta-researcher, Beatles fan, pizza connoisseur The Yale School of Public Health proudly welcomes a large number of new tenure track faculty joining us this academic year. These individuals have widely varied interests and excel in research, scholarship, innovation and teaching. They complement and expand the expertise already available at the School of Public Health and will be instrumental in addressing many of the health challenges of the 21 st century.
Researchers have created new machine learning software that can forecast the survival rates and response to treatments of patients with ovarian cancer The artificial intelligence software, created by researchers at Imperial College London and the University of Melbourne , has been able to predict the prognosis of patients with ovarian cancer more accurately than current methods.
Machine learning algorithm helps in the search for new drugs
Researchers have designed a machine learning algorithm for drug discovery which has been shown to be twice as efficient as the industry standard, which could accelerate the process of developing new treatments for disease. The ability to fish out four active molecules from six million is like finding a needle in a haystack Alpha Lee The researchers, led by the University of Cambridge, used their algorithm to identify four new molecules that activate a protein which is thought to be relevant for symptoms of Alzheimer's disease and schizophrenia.
Researchers have designed a machine learning algorithm for drug discovery which has been shown to be twice as efficient as the industry standard, which could accelerate the process of developing new treatments for disease. The ability to fish out four active molecules from six million is like finding a needle in a haystack Alpha Lee The researchers, led by the University of Cambridge, used their algorithm to identify four new molecules that activate a protein which is thought to be relevant for symptoms of Alzheimer's disease and schizophrenia.
Cell component breakdown suggests possible treatment for multiple neural disorders
UW-Madison research published today (Feb. 11, 2019) reveals how one mutation causes fragile X, the most common inherited intellectual disability. "Fragile X syndrome has been studied as a model of intellectual disability because in theory it's comparatively simple," says senior author Xinyu Zhao, a professor of neuroscience in the Waisman Center at the University of Wisconsin-Madison.
UW-Madison research published today (Feb. 11, 2019) reveals how one mutation causes fragile X, the most common inherited intellectual disability. "Fragile X syndrome has been studied as a model of intellectual disability because in theory it's comparatively simple," says senior author Xinyu Zhao, a professor of neuroscience in the Waisman Center at the University of Wisconsin-Madison.
A UCLA-led study suggests that for people with recurrent glioblastoma, administering an immunotherapy drug before surgery is more effective than using the drug afterward. In recent years, immunotherapy drugs, which harness the body's immune system to destroy cancer cells, have been shown to be helpful in treating people with advanced or metastatic cancer.
Under the influence of the drug fluconazole, the fungus Candida albicans can change its mode of reproduction and thus become even more resistant. Scientists at the University of Würzburg report this in the journal mBio. The yeast Candida albicans occurs in most healthy people as a harmless colonizer in the digestive tract.
Inaccurate tests carried out on tuberculosis patients in developing countries often fail to reliably detect resistance to drugs, leading to incorrect treatment and a higher mortality rate. These are the results of study by an international group of researchers led by a team at the University of Bern published today.
Capsule that releases insulin in the stomach could replace injections for patients with type 2 diabetes. About the size of a blueberry, the capsule contains a small needle made of compressed insulin, which is injected after the capsule reaches the stomach. In tests in animals, the researchers showed that they could deliver enough insulin to lower blood sugar to levels comparable to those produced by injections given through skin.
Prostate Cancer UK has awarded researchers over £1.3 million for three projects that could lead to new treatments for the disease. The Research Innovation Awards is a prestigious scheme aimed at funding the most impactful research in prostate cancer. The number of prostate cancer cases is increasing in the UK - the condition kills over 11,000 men every year - and research is desperately needed to find new ways of tackling the disease.
Placebo effects do not only occur in medical treatment - placebos can also work when psychological effects are attributed to them. Psychologists from the University of Basel reported these findings in the journal Scientific Reports, based on three studies with over 400 participants. Psychotherapy and placebos are both psychological interventions that not only have comparable effects, but that are also based on very similar mechanisms.
New test rapidly evaluates the effect of drugs and potentially toxic compounds on cells. Measuring the toxic effects of chemical compounds on different types of cells is critical for developing cancer drugs, which must be able to kill their target cells. Analyzing cell survival is also an important task in fields such as environmental regulation, to test industrial and agricultural chemicals for possible harmful effects on healthy cells.
Hope on the horizon
There are currently an estimated 100,000 people in the United States who are living with sickle cell disease-a debilitating and life-threatening blood condition that predominantly affects people of African and Mediterrane an descent, and Hispanic-Americans from Central and South America. For years, those who suffer from the disease have been treated with temporary solutions, but now advances in gene therapy have opened doors to a possible cure.
There are currently an estimated 100,000 people in the United States who are living with sickle cell disease-a debilitating and life-threatening blood condition that predominantly affects people of African and Mediterrane an descent, and Hispanic-Americans from Central and South America. For years, those who suffer from the disease have been treated with temporary solutions, but now advances in gene therapy have opened doors to a possible cure.
New vaccine for malaria developed at IME could be more effective
Researchers at the Institute for Molecular Engineering at the University of Chicago have developed an innovative new system for delivering a malaria vaccine that shows promise in its effectiveness. By developing a vaccine that targets specific cells in the immune system, they have seen a much greater immune and antibody response to the vaccine.
Researchers at the Institute for Molecular Engineering at the University of Chicago have developed an innovative new system for delivering a malaria vaccine that shows promise in its effectiveness. By developing a vaccine that targets specific cells in the immune system, they have seen a much greater immune and antibody response to the vaccine.
When researchers make a new discovery, they tend to only publish the results of their successful experiments. But just as informative are all the experiments that didn't work - the failed trials and incorrect hypotheses, which can offer important information. A team of EPFL chemists has developed a methodology for collecting those lessons and, crucially, sharing them with other researchers.