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Health - Pharmacology - 24.08.2021
Low or undetectable immune response to double COVID-19 vaccination in patients with impaired immune systems
Study shows low or undetectable immune response to double COVID-19 vaccination in patients with impaired immune systems The first data from the ongoing OCTAVE study show that a significant proportion of clinically at-risk patients with certain immunocompromised or immunosuppressed conditions mount a low or undetectable immune response after two doses of the same COVID-19 vaccine.

Health - Life Sciences - 24.08.2021
Farmed carnivores may become 'disease reservoirs' posing human health risk
Farmed carnivores may become ’disease reservoirs’ posing human health risk
Carnivorous animals lack key genes needed to detect and respond to infection by pathogens, a study has found. We've found that a whole cohort of inflammatory genes is missing in carnivores Clare Bryant Farming large numbers of carnivores, like mink, could allow the formation of undetected 'disease reservoirs', in which a pathogen could spread to many animals and mutate to become a risk to human health.

Health - 24.08.2021
Reducing mechanical ventilation can improve outcomes for critically ill children
Reducing mechanical ventilation can improve outcomes for critically ill children
A new clinical approach that reduces the use of mechanical ventilation can greatly improve outcomes for critically ill infants and children, finds a major new UK trial involving UCL researchers.

Health - 24.08.2021
Significant rise in ’high-risk’ behaviour during second lockdown
Despite near identical restrictions, 'high-risk behaviours' were significantly higher in the second Covid-19 lockdown than the first, finds a new UCL led study. The research, published in PNAS , found that during the second (November) lockdown people in the UK spent 35 minutes longer, on average, engaged in 'high risk' behaviours (where 'high risk' is identified as mixing with people outside the household, or doing work or leisure activities away from home), compared with the first (March to July).

Health - Pharmacology - 24.08.2021
Hospital-acquired COVID-19 tends to be picked up from other patients, not from healthcare workers
Hospital-acquired COVID-19 tends to be picked up from other patients, not from healthcare workers
The majority of patients who contracted COVID-19 while in hospital did so from other patients rather than from healthcare workers, concludes a new study from researchers at the University of Cambridge and Addenbrooke's Hospital.

Health - 24.08.2021
Viruses leave traces for long after infection
Viruses leave traces for long after infection
Viruses do not always kill the cells they infect. Researchers at the University of Basel have discovered in experiments with mice that cells have the power to self-heal and eliminate viruses. However, these cells undergo long-term changes. The findings may provide a hint as to why cured hepatitis C patients are more susceptible to liver cancer for years after.

Health - Pharmacology - 24.08.2021
Vaccine responses in patients with impaired immune systems
OCTAVE study reveal vaccine responses in patients with impaired immune systems Initial data from the ongoing OCTAVE study shows that a significant proportion of clinically at-risk patients with certain immunocompromised or immunosuppressed conditions, mount a low, or undetectable, immune response after two doses of the same COVID-19 vaccine.

Life Sciences - Health - 23.08.2021
Understanding how elephants use their trunk
Understanding how elephants use their trunk
A multidisciplinary team of scientists from the UNIGE identified how elephants evolved strategies that reduce the biomechanical complexity of their trunk. The elephant proboscis (trunk) exhibits an extraordinary kinematic versatility as it can manipulate a single blade of grass but also carry loads up to 270 kilograms.

Health - 23.08.2021
Study of Health Innovation Manchester role published in international journal
A paper examining the role of Health Innovation Manchester as an Academic Health Science System has been published in an international journal. The paper, published in the International Journal of Integrated Care, is possibly the first examination of the earliest implementation of the Academic Health Science System (AHSS) concept in the UK, and certainly the first implementation at scale.

Life Sciences - Health - 23.08.2021
Brain organoids with complex neural activity
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed brain organoids — 3D brain-like structures grown from human stem cells — that show organized waves of activity similar to those found in living human brains. Then, while studying organoids grown from stem cells derived from patients with the neurological disorder Rett syndrome, the scientists were able to observe patterns of electrical activity resembling seizures, a hallmark of the condition.

Health - Pharmacology - 23.08.2021
Patients helping researchers to advance treatments for prostate cancer
Patients helping researchers to advance treatments for prostate cancer
One of the most common cancers, prostate cancer is also one of the most difficult to study in the laboratory, with the frequently used models derived more than 40 years ago. With the establishment of the Melbourne Urological Research Alliance (MURAL), hundreds of Victorian men have generously donated samples of their cancer tissue, enabling the team to study a greater diversity of live tumours and test the efficacy of a larger variety of therapies for their ability to stop tumour growth.

Psychology - Health - 20.08.2021
Hearing loss could be cause of depression in older people
University of Manchester researchers have discovered that hearing loss may act as a cause of depression in older people. And those in the lowest wealth groups, they found, had up to twice the relative risk of developing depression than those in the highest wealth quintiles, as hearing loss disproportionally affected their quality of life.

Health - Pharmacology - 20.08.2021
Class of diabetes drugs reduces heart attacks, strokes, heart failure and death
A newer class of diabetes medications, called GLP-1 receptor agonists, has been shown to reduce the chance of heart attacks, strokes and death from cardiovascular disease by 14-15%, as well as all-cause mortality by 12-13%. This large meta-analysis study - led by the University of Glasgow and published today in the Lancet Diabetes and Endocrinology - summarises the safety and net benefits of this class of drugs, and also found that they lower risk of hospital admission for heart failure, as well as reduced important kidney outcomes.

Health - Psychology - 20.08.2021
High levels of suicidal ideation and depression symptoms observed during lockdown
High levels of suicidal ideation and depression symptoms observed during lockdown
The study involved Monash University, Austin Health, and Brigham and Women's Hospital in the United States, and was led by Professor Shantha Rajaratnam and PhD candidate Mr Mark Czeisler, from the Monash University Turner Institute for Brain and Mental Health and School of Psychological Sciences.

Life Sciences - Health - 19.08.2021
Creation of a detailed 'catalogue' of degradation products in cells
Creation of a detailed ’catalogue’ of degradation products in cells
Cells have their own quality control to prevent the production and accumulation of harmful proteins. This quality control is essential for correct embryonic development in all mammals and plays an important role in tumors and genetic diseases such as cystic fibrosis. A group of researchers from the University of Bern and the University of Basel have now made visible and cataloged for the first time, "blueprints" that give rise to defective proteins and are normally recognized and rapidly degraded in cells.

Materials Science - Health - 19.08.2021
Band-aid for internal wounds
Band-aid for internal wounds
Closing wounds in the digestive tract is a challenge. researchers have now developed a polymer patch for the intestine that can be used to stably bond and seal internal injuries. A burst appendix or a life-threatening intestinal volvulus are emergencies that need to be treated by surgeons immediately.

Health - Life Sciences - 19.08.2021
Hidden SARS-CoV-2 ’Gate’ That Opens to Allow COVID Infection
Supercomputing-derived movies reveal details of deceptive sugar coating on spike protein, presenting new possibilities to block cell entry and infection Since the early days of the COVID pandemic, scientists have aggressively pursued the secrets of the mechanisms that allow severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter and infect healthy human cells.

Life Sciences - Health - 18.08.2021
Neuroscience Institute Researchers at Black in Neuro
Carnegie Mellon University Carnegie Mellon University neuroscience was well represented at Black In Neuro Week 2021 , the second annual celebration of Black excellence in neuroscience related fields. Sossena Wood , a current presidential postdoctoral fellow who will transition to assistant professor in January 2022, gave the keynote address.

Life Sciences - Health - 18.08.2021
Key Mechanisms behind Synapse Degeneration in Alzheimer’s Brain
Targeting newly identified signaling pathway holds promise for treatments of neurodegenerative disorders Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system.

Health - Pharmacology - 18.08.2021
New approach identifies T cells in Covid-19 patients
New approach identifies T cells in Covid-19 patients
Immune cell profile reveals appearance, number and activity level against SARS-CoV-2 T cells play a decisive role in fighting the coronavirus and preventing infected individuals from becoming seriously ill. They identify and fight the virus directly within the infected cells. A team of researchers working in Munich have produced a precise profile of the T cells that respond to SARS-CoV-2 and described them at various stages of the illness.
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