Results 81 - 100 of 15193.

Social Sciences - Health - 13.07.2021
Teens with a history of self-harm have a significantly higher threshold for pain
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London, in collaboration with Glasgow University, has found that teenagers who have self-harmed five or more times in their life have a significantly higher threshold for pain compared to adolescents that have not.

Health - Pharmacology - 12.07.2021
Selective, Toxin-Bearing Antibodies Could Help Treat Liver Fibrosis
In mouse models of human disease, immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.

Health - Pharmacology - 12.07.2021
Artificial Intelligence Could Be New Blueprint for Precision Drug Discovery
Mathematical approach could transform drug development by searching for disease targets, then predicting if a drug will be successful Writing in the July 12, 2021 online , researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval.

Health - Life Sciences - 12.07.2021
Researchers define the molecular mechanism that drives the initial step of tumour metastasis
An international research team has defined the molecular mechanism that drives the initial step of tumour metastasis -intravasationwhen tumour cells enter vascular and/or lymphatic vessels. Understanding tumour cell intravasation is the key to future therapeutic developments to block the spread of tumour cells from their primary site, before the onset of metastasis.

Health - Social Sciences - 09.07.2021
Covid-19: Risks of severe illness in children shown to be very low
The risk of severe illness and death from SARS-CoV-2, the virus that causes Covid-19, is extremely low in children and teenagers, according to the most comprehensive analyses of public health data, co-led by researchers at UCL. However, Covid-19 increases the likelihood of serious illness in the most vulnerable young people, those with pre-existing medical conditions and severe disabilities, although these risks remain low overall.

Health - Life Sciences - 09.07.2021
An 'astounding' find reveals a rare cause of epilepsy
An ’astounding’ find reveals a rare cause of epilepsy
Researchers at The University of Queensland, working to gain a better understanding of how brain cells work, have discovered the underlying mechanism of a rare genetic mutation that can cause epilepsy. Dr Victor Anggono from UQ's Queensland Brain Institute said his team made the ground-breaking findings while researching nerve cell communications, which are an important process in normal brain function.

Life Sciences - Health - 09.07.2021
Machine-learning improves the prediction of stroke recovery
Machine-learning improves the prediction of stroke recovery
An international team of scientists led by EPFL has developed a system that combines information from the brain's connectome - the "wiring" between neurons - and machine learning to assess and predict the outcome of stroke victims. When blood flow to the brain is somehow reduced or restricted, a person can suffer what we know as a stroke (from "ischemic stroke" in medical jargon).

Health - Pharmacology - 09.07.2021
Commonalities found between COVID-19 and Rheumatoid Arthritis could help development of new treatment strategies for Long Covid
Severe COVID-19 and Rheumatoid Arthritis (RA) share some common pathogenic mechanisms, according to a new study. The observations from the study - published in JCI Insight and led by the University of Glasgow's Research into Inflammatory Arthritis Centre (RACE) in collaboration with the Fondazione A.Gemelli IRCCS in Italy - could help development of new treatment strategies for severe COVID-19 and post-COVID-19 syndrome, or Long Covid.

Health - Life Sciences - 09.07.2021
Wearable Tech Aids Freedivers, Cardiac Patients
Carnegie Mellon University With dives lasting more than four minutes and reaching depths of more than 100 meters on a single-breath hold, freedivers test the limits of human endurance. Carnegie Mellon researchers are part of an international team working on wearable biomedical technology that will enhance freediver safety, as well as provide fresh treatment insights for cardiac patients.

Health - Pharmacology - 09.07.2021
Tool helps predicts who will respond best to targeted prostate cancer therapy
A new prognostic tool developed by researchers from the UCLA Jonsson Comprehensive Cancer Center and five other institutions helps p redict which men with advanced metastatic prostate cancer will respond favorably to a novel targeted therapy. The tool, described in a study published today in Lancet Oncology, analyzes a wide spectrum of imaging and clinical data and is intended to assist physicians considering treating patients with Lutetium-177 prostate-specific membrane antigen, or LuPSMA.

Health - Life Sciences - 08.07.2021
A 'molecular switch' turns on the unfavorable evolution of prostate tumors
A ’molecular switch’ turns on the unfavorable evolution of prostate tumors
Researchers from the Prostate Cancer Biology laboratory, directed by Giuseppina Carbone, M.D., at the Institute of Oncology Research (IOR, affiliated to USI) in Bellinzona, have discovered an unexpected mechanism that drives the largest group of prostate tumors' evolution, the ERG fusion-positive prostate cancers.

Life Sciences - Health - 08.07.2021
Brain research uncovers 'perfect storm' linked to neurodegenerative disease
Brain research uncovers ’perfect storm’ linked to neurodegenerative disease
A 'perfect storm' of genetic mutations, toxic proteins and a defect in natural cell recycling has been uncovered in University of Queensland research that could lead to treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's. Researchers have found brain cells are particularly vulnerable to the impacts of the triple threat, and two genes - PINK-1 and PDR-1 - are likely to contribute significantly to that vulnerability.

Health - 08.07.2021
New report aims to make musculoskeletal health a global priority
A global team of researchers has mapped the landscape for the prevention and management of musculoskeletal conditions - the world's leading cause of pain, disability and healthcare expenditure - and developed a blueprint.

Environment - Health - 08.07.2021
World's largest study of global climate related mortality links 5 million deaths a year to abnormal temperatures
World's largest study of global climate related mortality links 5 million deaths a year to abnormal temperatures
The study found deaths related to hot temperatures increased in all regions from 2000 to 2019, indicating that global warming due to climate change will make this mortality figure worse in the future. The international research team, led by Monash University's Professor Yuming Guo , Dr Shanshan Li , and Dr Qi Zhao from Shandong University in China - and published today in The Lancet Planetary Health - looked at mortality and temperature data across the world from 2000 to 2019, a period when global temperatures rose by 0.26C per decade.

Health - Life Sciences - 07.07.2021
MHH fills important gap in lung research
MHH fills important gap in lung research
For the first time, a team of scientists clearly demonstrates the existence of lipofibroblasts in human luectron microscope In medical research, animal models are used to clarify the development of diseases and to develop suitable therapies. In order to be able to transfer the results to humans, however, it must be ensured that the cell types and molecular signalling pathways studied in detail actually occur in our bodies.

Life Sciences - Health - 07.07.2021
Rare genetic variants confer largest increase in type 2 diabetes risk seen to date
Rare genetic variants confer largest increase in type 2 diabetes risk seen to date
Scientists at the University of Cambridge have identified rare genetic variants - carried by one in 3,000 people - that have a larger impact on the risk of developing type 2 diabetes than any previously identified genetic effect. For complex diseases such as type 2 diabetes, many variants play a role [in disease risk], but often only increasing our risk by a tiny amount.

Chemistry - Health - 07.07.2021
New approach will help identify drugs that can ’glue’ proteins together
A new screening method that can test the effectiveness of therapeutic molecules designed to 'glue' proteins together in the body has been developed by researchers at the University of Birmingham and the University of Leicester. The research paves the way for drug developers to screen large numbers of potential new drug compounds to discover new treatments for diseases such as breast cancer and Parkinson's disease.

Health - Life Sciences - 07.07.2021
Researchers identify an early neuronal dysfunction in Parkinson's that could help early diagnosis
Researchers identify an early neuronal dysfunction in Parkinson’s that could help early diagnosis
Parkinson's is a neurodegenerative disease characterized by the loss of dopaminergic neurons, a process involving motor manifestations such as tremors, rigidity, slow movements, and postural instability. Although in many cases the cause of the disease is still unknown, mutations in the LRRK2 gene are responsible for 5% of the cases.

Health - Pharmacology - 07.07.2021
Arthritis drugs save lives of hospitalised Covid-19 patients
Drugs used to treat arthritis, known as interleukin-6 antagonists, reduce deaths and the need for mechanical ventilation among people hospitalised with Covid-19, according to a new study involving UCL which has prompted new World Health Organization (WHO) recommendations. In the study, published in the Journal of the American Medical Association , researchers analysed 27 randomised trials involving nearly 11,000 patients.

Health - 07.07.2021
Women who vape are more likely to have low-birthweight babies
Women who use electronic cigarettes during pregnancy are 33% more likely than those who don't to give birth to low-birthweight infants, according to a new study by a team of researchers from UCLA and other institutions. Low-birthweight babies — those weighing less than 5.5 pounds — often require specialized medical care and are at greater risk of early-life complications and long-lasting health issues, said Annette Regan , the study's corresponding author and an adjunct assistant professor of epidemiology at the UCLA Fielding School of Public Health.