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Monash researchers have shown for the first time that mesenteric (gut) lymphatic dysfunction is a potential cause of and therapeutic target for obesity and insulin resistance. The ground-breaking study identified a profoundly damaging cycle in which a high fat diet promotes dysfunction of the mesenteric lymphatics, that in turn leads to accumulation of abdominal fat.

Researchers studied a group of patients who were being treated for advanced melanoma with immune checkpoint blockade (ICB) - the main immunotherapy drugs currently used to treat cancer - to identify biomarkers of response and toxicity. They found that higher levels of the bacterium Bacteroides intestinalis in the gut were associated with a greater likelihood of developing moderate to severe treatment-related side effects.

In Australia, someone suffers a stroke every 19 minutes and it is one of Australia's biggest killers. In addition, nearly half of all survivors of stroke are expected to experience a recurrent cardiovascular event within 10 years. Specific medications help to prevent this long-term risk, but adherence to these agents is often suboptimal among patients.

There have been 260 major fires detected in the Amazon this year, burning more than 105,000 hectares (260,000 acres) — an area roughly the size of Los Angeles, California. More than 75 per cent of these fires blazed in the Brazilian Amazon, in areas where trees have been cut to make way for agriculture, despite a June 27 ban on unauthorized outdoor fires by the Brazilian government.

The landmark study, published today in The Lancet Planetary Health, looked at data of more than 65.6 million deaths, from all causes, in 749 cities in 43 countries and regions from January 1, 2000 to December 31, 2016 - cross referencing to daily concentrations of wildfire PM 2.5 concentrations.

Monash researchers unlock the key that could lead to the development of non-opioid painkillers to treat chronic pain Monash researchers have made a breakthrough discovery that could pave the way for the development of novel non-opioid painkillers (analgesics) to safely and effectively treat neuropathic pain.

However, it was a bad report for major companies IDP Education, Fisher and Paykel Healthcare, Cleanaway, Resmed and Nine Entertainment, which performed poorly on the modern slavery score. The findings were based on statements available from S&P/ASX100 companies (ASX 100) from the last financial year, ending June 2021, and identified that there was a wide variation in the information disclosed relating to the modern slavery statements submitted by each of the ASX100 companies.

The first large-scale study of Electronic Medical Record (EMR) usability in Australia has found nursing and medical professionals have differing experiences depending on where they work. Led by Griffith University, the study published in The International Journal of Medical Informatics captured views from medical, nursing and allied health professionals across the acute, primary and community care sectors.

Researchers from Monash University and Australian National University (ANU) have assessed the impact of high levels of mercury in the sediments of Lake Macquarie in New South Wales due to nearby coal-fired power plants. Many estuaries across Australia are at risk of increasing levels of metal contamination, particularly mercury (Hg) contamination from nearby coal-fired power plants and their associated ash dams.

One of the most common cancers, prostate cancer is also one of the most difficult to study in the laboratory, with the frequently used models derived more than 40 years ago. With the establishment of the Melbourne Urological Research Alliance (MURAL), hundreds of Victorian men have generously donated samples of their cancer tissue, enabling the team to study a greater diversity of live tumours and test the efficacy of a larger variety of therapies for their ability to stop tumour growth.

The study involved Monash University, Austin Health, and Brigham and Women's Hospital in the United States, and was led by Professor Shantha Rajaratnam and PhD candidate Mr Mark Czeisler, from the Monash University Turner Institute for Brain and Mental Health and School of Psychological Sciences.

The research has shown that to close the gender gap and enable women to achieve their career goals, organisations need to adopt dedicated leadership and commit to ground up co-development with women and the broader workforce to meet their needs in implementing the interventions in the long-term. Integrating 20 years of research, findings highlight the need for effective interventions that sit across five categories: organisational processes; awareness and engagement; mentoring and networking; leadership development; and support tools.

A Monash researcher is part of an international consortium of scientists that has developed a CRISPR-based COVID-19 diagnostic test that, with the help of a smartphone camera, can provide a positive or negative result in 20 minutes and detect how contagious a person is. Current highly sensitive, accurate tests for COVID-19 can take more than two days to produce a result, requiring a person to isolate for that time.

The first award under BioCurate's new "Proof of Concept" fund has been granted to the Monash Biomedicine Discovery Institute (BDI). This award will support the key research needed to determine the effectiveness of targeting two proteins that could lead to novel, targeted treatments for triple negative breast cancer (TNBC) and other poor prognosis cancers.

Importantly, the study found that in women who suffer from insomnia symptoms during pregnancy, the benefits of CBT in enhancing the quality of their sleep lasted throughout the first two years post-birth. The study, led by Dr Bei Bei , from Monash University's Turner Institute for Brain and Mental Health, and published today in the journal, Psychological Medicine, suggests that CBT for better sleep should become a part of routine perinatal care.

"What you realise really quickly in times like this is that you're actually a community leader. What I mean by that is outside of sort of a political voice that our members of parliament have, it seems that the next voice that many community members go to, particularly families, is to school leaders." Danni, government secondary school Principal.

Published in the Journal of the American Heart Association , the findings may identify people at increased risk of major cognitive impairment, allowing for triage into heightened surveillance, and point the way to new areas for research. The new paper is one of many important health findings yielded from the ASPREE (ASPirin in Reducing Events in the Elderly) dataset.

The new research from Monash University's Insurance Health Work Group, part of the School of Public Health and Preventive Medicine, was published in The Journal of Occupational Rehabilitation , just as some states emerge from snap lockdowns and Sydney's is extended until local transmission is under control.

The study found deaths related to hot temperatures increased in all regions from 2000 to 2019, indicating that global warming due to climate change will make this mortality figure worse in the future. The international research team, led by Monash University's Professor Yuming Guo , Dr Shanshan Li , and Dr Qi Zhao from Shandong University in China - and published today in The Lancet Planetary Health - looked at mortality and temperature data across the world from 2000 to 2019, a period when global temperatures rose by 0.26C per decade.

One in three refugee and migrant women living in Australia have experienced some form of domestic and family violence, with nearly a quarter reporting this increased in severity during COVID-19 lockdowns last year, a first-of-its-kind study has revealed. Led by researchers from Monash University's Migration and Inclusion Centre (MMIC) and Harmony Alliance , the Migrant and Refugee Women in Australia: The Safety and Security Study report, released today, reveals the experiences and needs of women across Australia's diverse migrant and refugee communities.