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Pharmacology - Health - 15.06.2021
Medication may help heavy-drinking smokers improve their health
A recent UCLA clinical trial has shown encouraging results in helping daily smokers who are also heavy drinkers quit smoking and cut down their alcohol intake. The study of 165 people tested two prescription drugs — varenicline, for smoking addiction, and naltrexone, which is used to treat alcoholism.

Health - Pharmacology - 10.06.2021
Drug commonly used as antidepressant helps fight cancer in mice
A class of drug called monoamine oxidase inhibitors is commonly prescribed to treat depression; the medications work by boosting levels of serotonin, the brain's "happiness hormone." A new study by UCLA researchers suggests that those drugs, commonly known as MAOIs, might have another health benefit: helping the immune system attack cancer.

Health - Pharmacology - 09.06.2021
Experts call for new standards for diagnostic tests to address testing problems during the COVID-19 pandemic
The Royal Statistical Society (RSS) has today published its review of the statistical evidence needed to assure the performance of future diagnostic tests, so we are better prepared for future pandemics. The RSS Working Group on Diagnostic Tests, which is co-chaired by University of Birmingham's Professor Jon Deeks , is calling on the Medicines and Healthcare Products Regulatory Agency (MHRA) to review and revise the national licensing process for in vitro diagnostic tests, to ensure that reliable evidence about the performance of tests is available and public safety is protected.

Pharmacology - Computer Science - 09.06.2021
’PrivacyMic’: For a smart speaker that doesn’t eavesdrop
Prototype technology could enable smart home systems that don't record speech Microphones are perhaps the most common electronic sensor in the world, with an estimated 320 million listening for our commands in the world's smart speakers. The trouble is that they're capable of hearing everything else, too.

Health - Pharmacology - 09.06.2021
A vital tool to study virus evolution in the test tube
Variants of viruses, such as that causing COVID-19, can now be quickly studied in the laboratory, even before they emerge in nature and become a major public health challenge. The University of Queensland, QIMR Berghofer Medical Research Institute , Peter Doherty Institute for Infection and Immunity , Monash University , and Queensland Health have developed a technology to manipulate viruses synthetically allowing rapid analysis and mapping of new potential virus variants.

Health - Pharmacology - 09.06.2021
Welsh study to transform UK brain tumour trials to find ’kinder’ therapies
A new Welsh study is aiming to revolutionise how clinical trials measure the impact of new brain tumour drugs on a patient's physical and emotional wellbeing, alongside assessment of their survival. Led by Professor Anthony Byrne from Cardiff University, and in collaboration with Professor Melanie Calvert from the University of Birmingham, the research will culminate in a consensus that will define the most important outcomes to measure, according to brain tumour patients, carers and professionals.

Health - Pharmacology - 08.06.2021
Common Diabetes Drug Shows Promise as Treatment for COVID-19 Lung Inflammation
The blood sugar-lowering drug metformin prevented pulmonary inflammation, a major factor in COVID-19 severity and mortality, in studies of mice infected by the SARS-CoV-2 coronavirus Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans.

Pharmacology - Health - 08.06.2021
Super Productive 3D Bioprinter Could Help Speed Up Drug Development
A 3D printer that rapidly produces large batches of custom biological tissues could help make drug development faster and less costly. Nanoengineers at the University of California San Diego developed the high-throughput bioprinting technology, which 3D prints with record speed—it can produce a 96-well array of living human tissue samples within 30 minutes.

Pharmacology - Health - 08.06.2021
Drug used to reduce blood sugar in diabetic patients can benefit hearts
Drug used to reduce blood sugar in diabetic patients can benefit hearts
A drug used to treat people living with Type 2 diabetes could also help improve their heart function, according to new research. An estimated 3.7 million people in the UK are diagnosed with the condition which can damage the walls of the arteries and lead to a heart attack or heart failure. Researchers at the University of Leeds' School of Medicine have discovered that Empagliflozin, which is typically prescribed to help reduce blood sugar levels in patients with Type 2, could also enhance the function of their hearts.

Health - Pharmacology - 08.06.2021
’Tiny first responders’ use powers for good against skin cancer
Researchers investigating a group of microscopic cells have discovered they can put the brakes on the rapid development of melanoma lesions. A team at the University of Queensland and collaborators from WEHI and Peter MacCallum Cancer Centre have taken a close look at the Group 2 innate lymphoid cells (ILC2) which are crucial for initiating and orchestrating immune responses.

Health - Pharmacology - 07.06.2021
Australian heart attack survival among best in world - but could be better
Australian heart attack survival among best in world - but could be better
Researchers have praised healthcare systems in Australia and New Zealand, after both nations recorded some of the world's best long-term recovery rates for heart attack sufferers. University of Queensland and Prince Charles Hospital cardiologist Associate Professor Isuru Ranasinghe and UQ Faculty of Medicine 's Dr Linh Ngo contributed to a study which found 62.3 per cent of heart attack sufferers in these nations lived a further seven years or more.

Pharmacology - Computer Science - 07.06.2021
Machine Learning Platform That Mines Nature for New Drugs
Carnegie Mellon University Researchers from Carnegie Mellon University's Computational Biology Department in the School of Computer Science have developed a new process that could reinvigorate the search for natural product drugs to treat cancers, viral infections and other ailments. The machine learning algorithms developed by the Metabolomics and Metagenomics Lab match the signals of a microbe's metabolites with its genomic signals and identify which likely correspond to a natural product.

Health - Pharmacology - 04.06.2021
Many patients with COVID-19 produce immune responses against their body’s own tissues or organs, finds study
A University of Birmingham-led study funded by the UK Coronavirus Immunology Consortium has found that many patients with COVID-19 produce immune responses against their body's own tissues or organs. COVID-19 has been associated with a variety of unexpected symptoms, both at the time of infection and for many months afterwards.

Health - Pharmacology - 03.06.2021
Study of UK dental professionals reveals extent of occupational risk of SARS-CoV-2 infection
A University of Birmingham-led study of over a thousand dental professionals has shown their increased occupational risk of SARS-CoV-2 infection during the first wave of the pandemic in the UK. The observational cohort study , published today (3 June 2021), in the Journal of Dental Research, involved 1,507 Midland dental care practitioners.

Health - Pharmacology - 03.06.2021
Two cellular pathways involved in TNBC tumour development and a promising targeted combination therapy
A team of researchers at the RI-MUHC found two cellular pathways involved in TNBC tumour development and a promising targeted combination therapy Montreal, June 2, 2021 - Breast cancer is the leading cause of cancer death in women around the world, responsible for 1,700 deaths every day. Although the vast majority of breast cancers are treatable, the most aggressive subtype - triple negative breast cancer (TNBC) - has a high recurrence rate, a high potential for metastasis and shows resistance to conventional treatments, leading to very poor prognosis and survival outcomes.

Health - Pharmacology - 02.06.2021
Opioid Agonist Therapy reduces mortality risk among people with opioid dependence
A new global review has found that receiving Opioid Agonist Therapy (OAT) is associated with lower risk of multiple causes of death among people with opioid dependence. The review, published in JAMA today [2 June], found that people with opioid dependence were less likely to experience overdose-related, suicide, alcohol-related, cancer, and cardiovascular-related mortality while receiving OAT.

Health - Pharmacology - 02.06.2021
Kidney failure patients among worst affected during COVID-19
Kidney failure patients among worst affected during COVID-19
The main risk factors associated with the significantly higher numbers of COVID-19 infection in dialysis patients, have been revealed in a study led by UCL researchers. In the UK, around 30,000 people with kidney failure or disease must visit a medical centre several times a week for dialysis treatment, which helps filter waste products from the blood. Globally the figure is around two million. As a result, these patients have been unable to self-isolate during lockdown, leaving them far more exposed to COVID-19 infection.

Pharmacology - Health - 02.06.2021
Replicating patients' tumours to test different treatments
Replicating patients’ tumours to test different treatments
UNIGE Researchers have developed in vitro tumour models that incorporate components of the tumour and elements of the patient's immune system to test the effectiveness of treatments. Every tumour is different, every patient is different. So how do we know which treatment will work best for the patient and eradicate the cancer?

Health - Pharmacology - 02.06.2021
Very high use of antibiotics in COVID-19 treatment could be reduced
The very high use of antibiotics in patients hospitalised with COVID-19 is often not necessary, and risks worsening global antimicrobial resistance. New research led by the University of Glasgow as part of the ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) WHO Clinical Characterisation Protocol UK (CCP-UK), found that antibiotic use was very high in hospitalised COVID-19 patients in the UK during the first wave despite confirmed bacterial infection being uncommon.

Health - Pharmacology - 01.06.2021
Diet Plays Critical Role in NASH Progressing to Liver Cancer in Mouse Model
When fed diet high in fat and cholesterol, mice that overate became obese, diabetic and developed NASH, which progressed to kidney and cardiovascular disease and liver cancer Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage.
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