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Health - Pharmacology - 18.07.2024
Improving HIV treatment for children and adolescents - the right way
Improving HIV treatment for children and adolescents - the right way
Globally, around 2.6 million children and adolescents are currently living with HIV, the majority of them in Africa. These young people are much more likely to experience treatment failure than adults. Experts long assumed that testing for viral drug resistance could improve treatment in cases where treatment has failed.

Life Sciences - Pharmacology - 17.07.2024
Factors enabling a human RNA virus to mutate and facilitate its transmission identified
The Institute for Integrative Systems Biology (UV-CSIC) has conducted the first comprehensive analysis of all mutations in the protein set of coxsackievirus B3, which causes severe heart inflammation. The findings, published in Plos Biology, will help to identify regions of the virus genome with low tolerance to mutations, facilitating the development of drugs targeting these areas.

Pharmacology - Health - 17.07.2024
Scottish Brain Tumour Research Centre of Excellence to be established
University of Glasgow cancer scientists will play a leading role in a new research centre to help find a cure for the most aggressive form of brain cancer. The Scottish Brain Tumour Research Centre of Excellence is jointly funded by the charities Brain Tumour Research and Beatson Cancer Charity, and will be a unique collaboration based at laboratories at the University of Glasgow and the University of Edinburgh.

Health - Pharmacology - 17.07.2024
Key Driver for Epithelial Cancer Development Identified
Key Driver for Epithelial Cancer Development Identified
A distinct signaling pathway called TNF- drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF- program and become invasive. This finding could help to improve early detection and treatment of patients with cancers in skin, esophagus, bladder or colon, as researchers state.

Health - Pharmacology - 16.07.2024
New approach to improve targeted skin cancer therapies
Targeted therapies are a powerful weapon against skin cancer, but their side effects can severely impact a patient's quality of life. A new study shows that some targeted therapies manipulate signaling events in cells that line blood vessels and result in a weaker vascular barrier. This knowledge sheds some light on possible mechanisms leading to side effects and it can contribute to the development of better therapies for skin cancer.

Health - Pharmacology - 15.07.2024
SARS-CoV-2 infections have a long-term impact on the immune systemg
In a study recently published in the renowned journal "Allergy", a MedUni Vienna research team shows that COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. The findings could help to better understand the long-term consequences of an infection with SARS-CoV-2.

Life Sciences - Pharmacology - 15.07.2024
Anesthesia drug induces unconsciousness
Propofol, a drug commonly used for general anesthesia, derails the brain's normal balance between stability and excitability. There are many drugs that anesthesiologists can use to induce unconsciousness in patients. Exactly how these drugs cause the brain to lose consciousness has been a longstanding question, but MIT neuroscientists have now answered that question for one commonly used anesthesia drug.

Health - Pharmacology - 15.07.2024
Potential for increasing effectiveness of popular diabetes, weight-loss drugs
New research demonstrates potential for increasing effectiveness of popular diabetes, weight-loss drugs Study: Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice (DOI: 10.1172/JCI178250) A network of proteins found in the central nervous system could be harnessed to increase the effectiveness and reduce the side effects of popular diabetes and weight-loss drugs, according to new research from the University of Michigan.

Pharmacology - Health - 12.07.2024
Biomarkers reveal how patients with glaucoma may respond to treatment
Markers in the blood that predict whether glaucoma patients are at higher risk of continued loss of vision following conventional treatment have been identified by researchers at UCL and Moorfields Eye Hospital. Over 700,000 people in the UK have glaucoma and it is the leading cause of irreversible blindness worldwide.

Health - Pharmacology - 10.07.2024
Cancer experts outline critical challenges facing the new UK Government
Leading doctors and researchers have warned critical challenges in cancer care in the UK need to be urgently addressed by policymakers. In a review published in The Lancet Oncology , a team of UK cancer care professionals has outlined ten time-critical issues impacting the delivery of cancer care services by the NHS.

Health - Pharmacology - 10.07.2024
Researchers study differences in attitudes toward Covid-19 vaccines between women and men in Africa
While women and men self-reported similar vaccination rates, unvaccinated women had less intention to get vaccinated than men. While many studies over the past several years have examined people's access to and attitudes toward Covid-19 vaccines, few studies in sub-Saharan Africa have looked at whether there were differences in vaccination rates and intention between men and women.

Health - Pharmacology - 09.07.2024
Active substance identified for the prevention of chlamydial infections
Despite the significant increase in sexually transmitted diseases in recent years, there is currently no vaccine available against common bacterial pathogens such as chlamydia. In the search for ways to prevent infection, a research team from MedUni Vienna and the CeMM Research Center for Molecular Medicine has identified the active substance pentamidine as a promising candidate for the prophylaxis of chlamydial infections and possibly other bacterial sexually transmitted diseases.

Health - Pharmacology - 09.07.2024
Could a dietary fiber supplement offer long-awaited treatment for food allergy sufferers?
Study: Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy ( doi.org/10.1038/s41563'024 -01909-w ) A study from the University of Michigan has identified a potential new treatment for food allergies in inulin, a naturally occurring plant fiber commonly used as a supplement, a prebiotic in soda, and a replacement for sweeteners and for other products and purposes.

Health - Pharmacology - 08.07.2024
Active Plant Substance Reduces Pulmonary Hypertension
Active Plant Substance Reduces Pulmonary Hypertension
A substance derived from the plant Ardisia crenata works in a different way than existing drugs. And in doing so, it is highly effective. Pulmonary hypertension is a very serious disease that leads to heart failure and death in many patients. Searching for new treatment options, a team headed by Professor Daniela Wenzel and Alexander Seidinger from the Department of Systems Physiology at Ruhr University Bochum, Germany, tested the plant substance FR900359 - referred to as FR by the researchers.

Health - Pharmacology - 08.07.2024
AI able to identify drug-resistant typhoid-like infection from microscopy images in matter of hours
AI able to identify drug-resistant typhoid-like infection from microscopy images in matter of hours
Artificial intelligence (AI) could be used to identify drug resistant infections, significantly reducing the time taken for a correct diagnosis, Cambridge researchers have shown. The team showed that an algorithm could be trained to identify drug-resistant bacteria correctly from microscopy images alone.

Pharmacology - Health - 08.07.2024
A treatment for anorexia nervosa?
McGill-led research team may have discovered neurological mechanism underlying common eating disorder A McGill University-led research team working in collaboration with a French team (CNRS, INSERM and Sorbonne university) believes it has identified both the neurological mechanism underlying anorexia nervosa as well as a possible cure.

Health - Pharmacology - 05.07.2024
New approach to chronic pain  
Chronic pain is one of the most challenging problems facing society. It has a significant impact on the daily lives of 23% of the population, and the care given to patients experiencing persistent pain is often not appropriate. The Pain in Motion research group at the Vrije Universiteit Brussel (VUB) focuses on improving healthcare providers' understanding and treatment of persistent pain.

Health - Pharmacology - 04.07.2024
New anti-aging therapy identified
New anti-aging therapy identified
Scientists from USI in collaboration with italian scientists have made a significant discovery by identifying a novel anti-aging therapeutic. The study is published in the prestigious journal "Nature Aging". Aging is a primary risk factor for the development of numerous chronic diseases such as Alzheimer's disease, arthritis, chronic kidney disease and cancer.

Health - Pharmacology - 01.07.2024
Novel Blood Test Helps Improve Cancer Treatments
Novel Blood Test Helps Improve Cancer Treatments
Oncologists use biopsy and imaging techniques to diagnose and monitor tumor diseases and assess treatment success. UZH and USZ researchers have now further developed an advanced method to analyze liquid biopsies of DNA fragments in the blood. It is fast and practical, without putting much of a strain on patients.

Pharmacology - Health - 01.07.2024
Physical exercise prevents nerve damage during chemotherapy
Physical exercise prevents nerve damage during chemotherapy
Cancer treatments often cause nerve damage that can lead to long-lasting symptoms. Medication has proven ineffective in these cases. A sports scientist at the University of Basel, together with an interdisciplinary team from Germany, has now shown that simple exercises can prevent nerve damage. Cancer therapies have improved over the years.
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