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Pharmacology - Life Sciences - 26.01.2023
To improve existing antibiotics and develop new antimicrobial treatments
To improve existing antibiotics and develop new antimicrobial treatments
Recerca The lack of effective antibiotics is an increasingly serious threat to global health. In recent decades, only a few new antimicrobial agents have been able to reach the market. Designing new functionalities for already known antibiotics —or those that have fallen out of use due to toxicity— is one of the strategies to make up for this drug shortage.

Health - Pharmacology - 25.01.2023
New 3D ultrasound may improve accuracy of liver cancer treatment
New 3D ultrasound may improve accuracy of liver cancer treatment
Simulated study finds new robotic ultrasound system can optimize liver cancer ablation therapy By Lawson Health Research Institute, Special to Western News, January 25, 2023 By Lawson Health Research Institute, Special to Western News, January 25, 2023 A simulated study by researchers at Western University and Lawson Health Research Institute has found a new system that uses ultrasound to construct 3D-images could make treatment of liver cancer, using thermal ablation, more accurate.

Health - Pharmacology - 25.01.2023
New treatment of hepatic disorders of abnormal lipid deposition
The Experimental Therapeutics group , directed by Prof. Carlo V. Catapano at the Institute of Oncology Research (IOR, affiliated to USI and member of Bios+), in collaboration with Prof. Jonathan Hall at the Swiss Federal Institute of Technology in Zürich (ETH, Zurich) identified a novel mechanism for the treatment of hepatic disorders of abnormal lipid deposition.

Health - Pharmacology - 24.01.2023
Alcohol-related liver disease: mechanism could form basis for development of new therapies
Medicine & Science Alcohol-related liver disease is among the most common causes of morbidity and mortality worldwide. Due to an incomplete understanding of the factors contributing to disease development, liver transplantation is still the only available cure. A team led by Tim Hendrikx from MedUni Vienna's Department of Laboratory Medicine has now uncovered a new mechanism that plays an important role in the progression of the disease.

Pharmacology - Health - 24.01.2023
Studies at patients’ homes may improve accessibility and inclusiveness of drug research
Studies at patients' homes instead of at the hospital may improve access to clinical research. According to Amos de Jong, PhD candidate at Utrecht University, improved accessibility is necessary to find sufficient and representative study participants for clinical research aimed at developing new medicines and medical devices.

Pharmacology - 24.01.2023
Rapid production of antibubbles with a jet
Previous article Next article UT researchers succeeded in the rapid fabrication of microscopic -antibubbles-. Previous methods to produce these liquid droplets surrounded by an air layer were either lack of controllability or prone to clogging and were much slower. The team of researchers recently published their findings in the scientific journal Advanced Materials.

Health - Pharmacology - 23.01.2023
COVID-19 patients may retain elevated risk of death 18 months after infection
COVID-19 patients may retain elevated risk of death 18 months after infection
COVID-19 is associated with higher risks of cardiovascular disease and death in the shortand long-term, according to a study in nearly 160,000 unvaccinated participants co-led by a UCL researcher. The study, published today in Cardiovascular Research , a journal of the European Society of Cardiology, investigated outcomes in a group of adults mostly aged in their 60s.

Health - Pharmacology - 23.01.2023
Covid-19 in pregnant women can damage the placenta and the foetus
Medicine & Science Using prenatal magnetic resonance imaging, a group of MedUni Vienna researchers examined the placentas and foetuses of women who tested positive for SARS-CoV-2 during pregnancy. Their research results demonstrate that the different strains of the virus that emerged during the pandemic led to varying degrees of damage: especially involving pre-Omicron variants, the detected placental lesions could potentially harm both development and health in some of the affected unborn children.

Pharmacology - Psychology - 23.01.2023
Scientists explain emotional 'blunting' caused by common antidepressants
Scientists explain emotional ’blunting’ caused by common antidepressants
Scientists have worked out why common anti-depressants cause around a half of users to feel emotionally -blunted-. In a study published today, they show that the drugs affect reinforcement learning, an important behavioural process that allows us to learn from our environment. According to the NHS, more than 8.3 million patients in England received an antidepressant drug in 2021/22.

Health - Pharmacology - 20.01.2023
’Remarkable’ results in colon cancer trial
Giving colon cancer patients chemotherapy before surgery cuts the risk of the disease coming back, according to the results of a new clinical trial. The FOxTROT trial, a collaborative study by scientists at Leeds and the University of Birmingham, showed that giving colon cancer patients chemotherapy before rather than after surgery reduced the chance of cancer returning within 2 years by 28%.

Health - Pharmacology - 20.01.2023
Does COVID really damage your immune system and make you more vulnerable to infections? The evidence is lacking
Over the past month or two, many northern hemisphere countries including the US and the UK have seen a large wave of respiratory viral infections. These include RSV ( respiratory syncytial virus ), flu and COVID in all ages, as well as bacterial infections such as strep A in children. Sometimes these infections can be very serious.

Health - Pharmacology - 20.01.2023
Private patients receive treatment for heart conditions more often than those with basic health insurance
Patients in Switzerland with supplementary private health insurance are more likely to undergo cardiac procedures than those with only basic health insurance. This has been demonstrated in a study by researchers from the University of Basel and the Cantonal Hospital of Aarau. Switzerland has one of the most expensive healthcare systems in the world.

Pharmacology - Health - 19.01.2023
New hope for treatment of rare metabolic disease
Results of a controlled clinical trial with a new drug for the treatment of X-linked adrenoleukodystrophy To date, no pharmacological treatment exists for X-linked adrenoleukodystrophy, a progressive genetic metabolic disease that damages the adrenal glands, the spinal cord and the white matter of the nervous system.

Pharmacology - Health - 19.01.2023
Chemotherapy before surgery cuts risk of colon cancer returning, trial finds
Chemotherapy before surgery cuts risk of colon cancer returning, trial finds
Patients with early stage colon cancer benefit from 6 weeks of chemotherapy before surgery Giving colon cancer patients chemotherapy before surgery cuts their risk of the disease coming back, according to the results of a Cancer Research UK-funded clinical trial. The FOxTROT trial showed that giving colon cancer patients chemotherapy before rather than after surgery reduced the chance of cancer returning within 2 years by 28%.

Health - Pharmacology - 17.01.2023
Immunotherapy: a new two-in-one weapon against resistant tumors
Immunotherapy: a new two-in-one weapon against resistant tumors
Pressing the gas pedal and lifting the brake at the same time is the innovative idea of Dr. Nicolas Manel, Inserm researcher and team leader at the Institut Curie (Immunity and Cancer Unit - Institut Curie, Inserm) to improve the response to immunotherapies. For several years, the researchers have identified a signaling pathway - STING - that is essential for accelerating the response to immunotherapies.

Health - Pharmacology - 17.01.2023
Vaccination shown to protect against pregnancy complications from COVID-19 Omicron variant
Vaccination shown to protect against pregnancy complications from COVID-19 Omicron variant
The global network led by the Oxford Maternal and Perinatal Health Institute (OMPHI) at the University of Oxford has today published, in The Lancet , the results of the ' 2022 INTERCOVID Study ' conducted in 41 hospitals across 18 countries. To evaluate the impact of the COVID-19 Omicron variant on maternal and neonatal outcomes the researchers studied 1,545 pregnant women diagnosed with the variant and 3,073 non-diagnosed, concomitant pregnant women as controls.

Health - Pharmacology - 17.01.2023
Endogenous molecule protects from life-threatening complications after stem-cell transplantation
Endogenous molecule protects from life-threatening complications after stem-cell transplantation
Freiburg researchers find that an antimicrobial molecule modifies T-cell-signalling and thus attenuates overshooting immune reactions Acute Graft-versus-host disease (GvHD) is a life-threatening complication after leukemia treatment with allogeneic stem cell transplantation, i.e. the transplantation of cells from another person.

Pharmacology - Life Sciences - 17.01.2023
Paderborn scientist is researching new approaches to combat antibiotic-resistant germs
Paderborn scientist is researching new approaches to combat antibiotic-resistant germs
Dr. Adrian Keller receives Paderborn University Research Award Antibiotics are regularly used in medicine to fight bacterial infections. However, resistant germs to which drugs are unable to respond are now increasingly emerging, especially in hospitals. This is because as bacteria reproduce and further develop, their genetic material - i.e. their DNA - can change to make them resistant to antibiotics.

Pharmacology - Psychology - 17.01.2023
New study tests impact of coming off antidepressants on mood and thinking patterns
University psychologists aiming to improve help for people withdrawing from antidepressants want volunteers to come forward to participate in the new study. New research being led by a team of psychologists at the University of Bath hopes to provide evidence to improve the clinical care of people in the process of withdrawing from antidepressants.

Health - Pharmacology - 13.01.2023
Researchers closer to finding new lung cancer treatments
Researchers closer to finding new lung cancer treatments
Scientists from The Australian National University (ANU) and the Peter MacCallum Cancer Centre have discovered that a protein, called Menin, contributes to abnormal deactivation of specific genes in cancer cells. One of the hallmarks of cancer is that the normal regulation of genes is disrupted, and this causes cancer cells to look and behave differently to normal cells.
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