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Life Sciences - Pharmacology - 15.04.2024
An enzyme makes mushrooms 'magical'
An enzyme makes mushrooms ’magical’
An international research team has investigated the biosynthesis of psilocybin, the main ingredient of hallucinogenic mushrooms. They gained new insights into the structure and reaction mechanism of the enzyme PsiM. It plays a key role in the production of psilocybin. The results of the study were published in the journal "Nature Communications".

Health - Pharmacology - 15.04.2024
Canada likely to miss WHO’s Hepatitis C elimination target
Canada likely to miss WHO's Hepatitis C elimination target, research shows. Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus (HCV) by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.

Health - Pharmacology - 15.04.2024
Advance in immune cell screening uncovers receptors that target prostate cancer
Advance in immune cell screening uncovers receptors that target prostate cancer
FINDINGS A recent UCLA study demonstrates a new process for screening T cells, part of the body's natural defenses, for characteristics vital to the success of cell-based treatments. The method filters T cells based on the receptor proteins found on their surface - which enable them to latch onto certain threats - and the type and amount of cell-killing or immune response-triggering molecules that they secrete.

Chemistry - Pharmacology - 10.04.2024
New strategy for assessing the applicability of reactions
New strategy for assessing the applicability of reactions
Team from the University of Münster presents computer-aided method / Counteracting subjective bias in studies on the production of new chemical compounds Chemists often develop and optimise new chemical reactions using so-called model systems, i.e. simple, easily accessible substrates.

Health - Pharmacology - 10.04.2024
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
Inflammation plays a major role in allergic diseases, affecting at least 17 million people in France, including 4 million asthmatics. One of the molecules that initiates this process in the respiratory tract has just been identified. This molecule, a member of the alarmin family, is a major therapeutic target for the development of new treatments for respiratory allergies.

Health - Pharmacology - 08.04.2024
Better understanding of how breast cancer works
Better understanding of how breast cancer works
In her research into the response of breast cancer to the hormone estrogen, PhD candidate Stacey Joosten studied not only hormone-sensitive breast cancer in postmenopausal women but also in men and in women before the menopause. The aim was to gain an even better understanding of how this type of breast cancer works.

Pharmacology - Social Sciences - 08.04.2024
Economic solution to Canada’s opioid crisis
Waterloo student uses mathematical modelling to bring awareness to opioid-related death reduction method Nasal-administered naloxone is more cost-effective and could help reduce the number of opioid-related fatalities compared to the current publicly funded intermuscular version, a new study has found.

Health - Pharmacology - 08.04.2024
Long COVID leaves telltale traces in the blood
People with long COVID have distinct patterns of inflammation detectable in the blood, which could potentially be targeted with immune therapies. Findings from the largest UK study of patients hospitalised with SARS-CoV-2 infection show that long COVID leads to ongoing inflammation which can be detected in the blood.

Chemistry - Pharmacology - 08.04.2024
Cutting-edge ruthenium catalyst for new reaction discovery and optimisation
Researchers at The University of Manchester have achieved a groundbreaking advancement in catalyst technology. They have developed a new catalyst which has been shown to have a wide variety of uses and the potential to streamline optimisation processes in industry and support new scientific discoveries.

Health - Pharmacology - 08.04.2024
Histopathological biomarkers for nanomedicine-based cancer therapy
Researchers from the Institute of Experimental Molecular Imaging at RWTH Aachen University publish results on the identification of suitable tumor patients in clinical trials for nanoparticle-based cancer therapies . Nanomedical formulations have attracted increasing public attention since the development of coronavirus vaccines.

Chemistry - Pharmacology - 08.04.2024
How Scientists Are Accelerating Chemistry Discoveries With Automation
Key Takeaways New automated workflow could enable real-time reaction analysis from a desktop computer instead of in a lab. Unlike conventional benchtop methods, the automated workflow could identify new chemical reaction products within a few hours instead of days. Could accelerate pharmaceutical drug discovery and development of new chemical reactions.

Pharmacology - 05.04.2024
People make more patient decisions when shown the benefits first
People make more patient decisions when shown the benefits first
Science + Technology Focusing immediately on the benefits of waiting might help people improve their self-control Key takeways UCLA psychologists asked experiment participants to choose to receive $40 in seven days or $60 in 30 days, for example, under a variety of time constraints. The experiment showed that people tend to make more impulsive decisions if they think about time delays first, and more patient decisions if they think about the greater reward associated with waiting longer.

Health - Pharmacology - 04.04.2024
Stool transplantation shows promise for Parkinson's disease
Stool transplantation shows promise for Parkinson’s disease
Dr. Arnout Bruggeman (VIB-UGent-UZ Gent), Prof. Debby Laukens (UGent), Prof. Roosmarijn Vandenbroucke (VIB-UGent) en Prof. Patrick Santens (UZ Gent) Clinical study shows stool transplantation of healthy gut bacteria reduces Parkinson's disease symptoms. Parkinson's disease (PD) is a common neurodegenerative disease that affects millions worldwide.

Pharmacology - Health - 03.04.2024
New Discovery Unravels Malaria Invasion Mechanism
New Discovery Unravels Malaria Invasion Mechanism
A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study, led by the Swiss Tropical and Public Health Institute (Swiss TPH) and Griffith University's Institute for Glycomics, reveals the role of a sugar called sialic acid in this invasion process.

Pharmacology - Health - 01.04.2024
New synthesis platform allows for rapid cancer drug synthesis and testing
New synthesis platform allows for rapid cancer drug synthesis and testing
Researchers have developed a new platform for the synthesis, analysis and testing of new compounds which may one day treat cancer The discovery of new compounds with pharmacological properties can be expensive and time-consuming. Therefore, there is an increasing interest in developing workflows that allow for the rapid synthesis and testing of multiple compounds in parallel.

Health - Pharmacology - 28.03.2024
TB vaccine may enable elimination of the disease in cattle by reducing its spread
Vaccination not only reduces the severity of TB in infected cattle, but reduces its spread in dairy herds by 89%, research finds. Our study suggests that vaccination not only reduces the progression of the disease, but that if vaccinated animals become infected, they are substantially less infectious to others.

Psychology - Pharmacology - 27.03.2024
People with depression see no immediate change from common GP assessment
People with depression see no immediate change from common GP assessment
But PHQ-9 questionnaire used to monitor primary care patients did reveal benefits across six months A commonly used questionnaire adopted by GPs to monitor the treatment of depression does not provide any immediate benefits to patients, a new study has found. Primary care researchers testing the PHQ-9 assessment, which measures the severity of depression, found it did nothing to improve people's symptoms after 12 weeks.

Health - Pharmacology - 27.03.2024
How some heart medications impact gut health
How some heart medications impact gut health
UCalgary study finds certain medications decrease diversity and beneficial microorganisms found in the gut, which may affect overall health Our intestines house trillions of microorganisms known as the gut microbiota. These microorganisms are important players in both drug metabolism and certain conditions like high blood pressure, coronary artery disease and diabetes.

Health - Pharmacology - 27.03.2024
Locums and permanent GPs equally safe, study reassures patients
There is no evidence that locum doctors are less clinically competent or practice less safely than permanent doctors, a study in England led by University of Manchester researchers has shown. Some differences in practice and performance of locum and permanent GPs were found, however the researchers suggest they are likely to be shaped by the organisational setting and systems within which they work.

Pharmacology - Economics - 26.03.2024
How to prevent social desirability bias in surveys
Marketing researcher Rik Pieters has developed, together with colleagues from other universities, a new, indirect questioning technique to improve the chance that people answer truthfully. The technique can be used, for instance, in conducting surveys or in making policies. Chances are that people tend to give socially desirable answers to direct survey questions on sensitive subjects, like watching porn, smoking during pregnancy, theft in the supermarket or illegal acquisition of prescription drugs.
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