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Pharmacology - Health - 24.04.2024
Circadian rhythms can influence drugs’ effectiveness
MIT researchers find circadian variations in liver function play an important role in how drugs are broken down in the body. Giving drugs at different times of day could significantly affect how they are metabolized in the liver, according to a new study from MIT. Using tiny, engineered livers derived from cells from human donors, the researchers found that many genes involved in drug metabolism are under circadian control.

Health - Pharmacology - 23.04.2024
Liver cancer: Molecular signalling pathway of tumour development decoded
Liver cancer: Molecular signalling pathway of tumour development decoded
As a malignant disease of the liver cells, hepatocellular carcinoma (HCC) is one of the main causes of cancer-related deaths. While the treatment options for this aggressive type of cancer remain limited, the incidence is increasing. A research team led by Latifa Bakiri and Erwin Wagner from MedUni Vienna's Clinical Institute for Laboratory Medicine has now described a molecular signalling pathway that plays a key role in the development of liver cancer, thereby identifying a potential new starting point for the development of therapeutic treatments.

Health - Pharmacology - 22.04.2024
Predicting arrhythmia 30 minutes before it happens
Atrial fibrillation is the most common cardiac arrhythmia worldwide with around 59 million people concerned in 2019 . This irregular heartbeat is associated with increased risks of heart failure, dementia and stroke. It constitutes a significant burden to healthcare systems, making its early detection and treatment a major goal.

Health - Pharmacology - 22.04.2024
Common antibiotic may be helpful in fighting respiratory viral infections
Yale researchers say that nasal application of neomycin shows promise in the prevention and treatment of respiratory viral infections A new, Yale-led study suggests that a range of respiratory viral infections - including COVID-19 and influenza - may be preventable or treatable with a generic antibiotic that is delivered to the nasal passageway.

Health - Pharmacology - 19.04.2024
Training AI models to answer ’what if’’ questions could improve medical treatments
Machines can learn not only to make predictions, but to handle causal relationships. An international research team shows how this could make medical treatments safer, more efficient, and more personalised. Artificial intelligence techniques can be helpful for multiple medical applications, such as radiology or oncology, where the ability to recognise patterns in large volumes of data is vital.

Health - Pharmacology - 18.04.2024
Adolescent stress may raise risk of postpartum depression in adults
Adolescent stress may raise risk of postpartum depression in adults
Study suggests adolescent stress may raise risk of postpartum depression in adults A Johns Hopkins Medicine-led study suggests early-life stress may lead to prolonged elevation of the hormone cortisol after childbirth and in turn, postpartum depression A Johns Hopkins Medicine -led research team reports in a new study that social stress during adolescence in female mice later results in prolonged elevation of the hormone cortisol after they give birth.

Pharmacology - Health - 17.04.2024
Antipsychotics for dementia linked to more harms than previously acknowledged
Risks highest soon after starting drugs, underscoring need for increased caution in early stages of treatment, say experts Antipsychotic use in people with dementia is associated with higher risks of a wide range of serious health outcomes compared with non-use, according to a new study from a collaboration across the Universities of Manchester, Nottingham, Edinburgh and Dundee.

Health - Pharmacology - 17.04.2024
Preventing cardiovascular risk thanks to a tool for measuring arterial stiffness
Cardiovascular diseases represent the leading cause of death worldwide . Preventing cardiovascular risk by identifying the people most susceptible to these diseases is a major public health challenge. In a new study in this field, researchers from Inserm, Université de Lorraine and Nancy Regional University Hospital opted to focus on arterial stiffness and how it changes with age, given that ageing is associated with a loss of arterial flexibility.

Life Sciences - Pharmacology - 15.04.2024
An enzyme makes mushrooms 'magical'
An enzyme makes mushrooms ’magical’
An international research team has investigated the biosynthesis of psilocybin, the main ingredient of hallucinogenic mushrooms. They gained new insights into the structure and reaction mechanism of the enzyme PsiM. It plays a key role in the production of psilocybin. The results of the study were published in the journal "Nature Communications".

Health - Pharmacology - 15.04.2024
Canada likely to miss WHO’s Hepatitis C elimination target
Canada likely to miss WHO's Hepatitis C elimination target, research shows. Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus (HCV) by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.

Health - Pharmacology - 15.04.2024
Advance in immune cell screening uncovers receptors that target prostate cancer
Advance in immune cell screening uncovers receptors that target prostate cancer
FINDINGS A recent UCLA study demonstrates a new process for screening T cells, part of the body's natural defenses, for characteristics vital to the success of cell-based treatments. The method filters T cells based on the receptor proteins found on their surface - which enable them to latch onto certain threats - and the type and amount of cell-killing or immune response-triggering molecules that they secrete.

Chemistry - Pharmacology - 10.04.2024
New strategy for assessing the applicability of reactions
New strategy for assessing the applicability of reactions
Team from the University of Münster presents computer-aided method / Counteracting subjective bias in studies on the production of new chemical compounds Chemists often develop and optimise new chemical reactions using so-called model systems, i.e. simple, easily accessible substrates.

Health - Pharmacology - 10.04.2024
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
Inflammation plays a major role in allergic diseases, affecting at least 17 million people in France, including 4 million asthmatics. One of the molecules that initiates this process in the respiratory tract has just been identified. This molecule, a member of the alarmin family, is a major therapeutic target for the development of new treatments for respiratory allergies.

Health - Pharmacology - 08.04.2024
Better understanding of how breast cancer works
Better understanding of how breast cancer works
In her research into the response of breast cancer to the hormone estrogen, PhD candidate Stacey Joosten studied not only hormone-sensitive breast cancer in postmenopausal women but also in men and in women before the menopause. The aim was to gain an even better understanding of how this type of breast cancer works.

Pharmacology - Social Sciences - 08.04.2024
Economic solution to Canada’s opioid crisis
Waterloo student uses mathematical modelling to bring awareness to opioid-related death reduction method Nasal-administered naloxone is more cost-effective and could help reduce the number of opioid-related fatalities compared to the current publicly funded intermuscular version, a new study has found.

Health - Pharmacology - 08.04.2024
Long COVID leaves telltale traces in the blood
People with long COVID have distinct patterns of inflammation detectable in the blood, which could potentially be targeted with immune therapies. Findings from the largest UK study of patients hospitalised with SARS-CoV-2 infection show that long COVID leads to ongoing inflammation which can be detected in the blood.

Chemistry - Pharmacology - 08.04.2024
Cutting-edge ruthenium catalyst for new reaction discovery and optimisation
Researchers at The University of Manchester have achieved a groundbreaking advancement in catalyst technology. They have developed a new catalyst which has been shown to have a wide variety of uses and the potential to streamline optimisation processes in industry and support new scientific discoveries.

Health - Pharmacology - 08.04.2024
Histopathological biomarkers for nanomedicine-based cancer therapy
Researchers from the Institute of Experimental Molecular Imaging at RWTH Aachen University publish results on the identification of suitable tumor patients in clinical trials for nanoparticle-based cancer therapies . Nanomedical formulations have attracted increasing public attention since the development of coronavirus vaccines.

Chemistry - Pharmacology - 08.04.2024
How Scientists Are Accelerating Chemistry Discoveries With Automation
Key Takeaways New automated workflow could enable real-time reaction analysis from a desktop computer instead of in a lab. Unlike conventional benchtop methods, the automated workflow could identify new chemical reaction products within a few hours instead of days. Could accelerate pharmaceutical drug discovery and development of new chemical reactions.

Pharmacology - 05.04.2024
People make more patient decisions when shown the benefits first
People make more patient decisions when shown the benefits first
Science + Technology Focusing immediately on the benefits of waiting might help people improve their self-control Key takeways UCLA psychologists asked experiment participants to choose to receive $40 in seven days or $60 in 30 days, for example, under a variety of time constraints. The experiment showed that people tend to make more impulsive decisions if they think about time delays first, and more patient decisions if they think about the greater reward associated with waiting longer.