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Health - Pharmacology - 07.06.2021
Australian heart attack survival among best in world - but could be better
Australian heart attack survival among best in world - but could be better
Researchers have praised healthcare systems in Australia and New Zealand, after both nations recorded some of the world's best long-term recovery rates for heart attack sufferers. University of Queensland and Prince Charles Hospital cardiologist Associate Professor Isuru Ranasinghe and UQ Faculty of Medicine 's Dr Linh Ngo contributed to a study which found 62.3 per cent of heart attack sufferers in these nations lived a further seven years or more.

Pharmacology - Computer Science - 07.06.2021
Machine Learning Platform That Mines Nature for New Drugs
Carnegie Mellon University Researchers from Carnegie Mellon University's Computational Biology Department in the School of Computer Science have developed a new process that could reinvigorate the search for natural product drugs to treat cancers, viral infections and other ailments. The machine learning algorithms developed by the Metabolomics and Metagenomics Lab match the signals of a microbe's metabolites with its genomic signals and identify which likely correspond to a natural product.

Health - Pharmacology - 04.06.2021
Many patients with COVID-19 produce immune responses against their body’s own tissues or organs, finds study
A University of Birmingham-led study funded by the UK Coronavirus Immunology Consortium has found that many patients with COVID-19 produce immune responses against their body's own tissues or organs. COVID-19 has been associated with a variety of unexpected symptoms, both at the time of infection and for many months afterwards.

Health - Pharmacology - 03.06.2021
Study of UK dental professionals reveals extent of occupational risk of SARS-CoV-2 infection
A University of Birmingham-led study of over a thousand dental professionals has shown their increased occupational risk of SARS-CoV-2 infection during the first wave of the pandemic in the UK. The observational cohort study , published today (3 June 2021), in the Journal of Dental Research, involved 1,507 Midland dental care practitioners.

Health - Pharmacology - 03.06.2021
Two cellular pathways involved in TNBC tumour development and a promising targeted combination therapy
A team of researchers at the RI-MUHC found two cellular pathways involved in TNBC tumour development and a promising targeted combination therapy Montreal, June 2, 2021 - Breast cancer is the leading cause of cancer death in women around the world, responsible for 1,700 deaths every day. Although the vast majority of breast cancers are treatable, the most aggressive subtype - triple negative breast cancer (TNBC) - has a high recurrence rate, a high potential for metastasis and shows resistance to conventional treatments, leading to very poor prognosis and survival outcomes.

Health - Pharmacology - 02.06.2021
Opioid Agonist Therapy reduces mortality risk among people with opioid dependence
A new global review has found that receiving Opioid Agonist Therapy (OAT) is associated with lower risk of multiple causes of death among people with opioid dependence. The review, published in JAMA today [2 June], found that people with opioid dependence were less likely to experience overdose-related, suicide, alcohol-related, cancer, and cardiovascular-related mortality while receiving OAT.

Health - Pharmacology - 02.06.2021
Kidney failure patients among worst affected during COVID-19
Kidney failure patients among worst affected during COVID-19
The main risk factors associated with the significantly higher numbers of COVID-19 infection in dialysis patients, have been revealed in a study led by UCL researchers. In the UK, around 30,000 people with kidney failure or disease must visit a medical centre several times a week for dialysis treatment, which helps filter waste products from the blood.  Globally the figure is around two million.  As a result, these patients have been unable to self-isolate during lockdown, leaving them far more exposed to COVID-19 infection.

Pharmacology - Health - 02.06.2021
Replicating patients' tumours to test different treatments
Replicating patients’ tumours to test different treatments
UNIGE Researchers have developed in vitro tumour models that incorporate components of the tumour and elements of the patient's immune system to test the effectiveness of treatments. Every tumour is different, every patient is different. So how do we know which treatment will work best for the patient and eradicate the cancer?

Health - Pharmacology - 02.06.2021
Very high use of antibiotics in COVID-19 treatment could be reduced
The very high use of antibiotics in patients hospitalised with COVID-19 is often not necessary, and risks worsening global antimicrobial resistance. New research led by the University of Glasgow as part of the ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) WHO Clinical Characterisation Protocol UK (CCP-UK), found that antibiotic use was very high in hospitalised COVID-19 patients in the UK during the first wave despite confirmed bacterial infection being uncommon.

Health - Pharmacology - 01.06.2021
Diet Plays Critical Role in NASH Progressing to Liver Cancer in Mouse Model
When fed diet high in fat and cholesterol, mice that overate became obese, diabetic and developed NASH, which progressed to kidney and cardiovascular disease and liver cancer Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage.

Pharmacology - 01.06.2021
Getting stoned: revealing the mysteries of stonefish venom
Getting stoned: revealing the mysteries of stonefish venom
University of Queensland scientists working to unlock the mysteries Australia's deadly stonefish have made a discovery which could change how sting victims are treated in the future. Stonefish are the most venomous fish in world and are found throughout shallow coastal waters of the northern half of Australia.

Pharmacology - Life Sciences - 01.06.2021
Protecting the IQ of people at risk for psychosis
Protecting the IQ of people at risk for psychosis
A team from the University of Geneva has found that a class of drugs can protect the development of intellectual abilities in people at risk of psychosis, if prescribed before adolescence. One person in 2000 suffers from a microdeletion of chromosome 22 that can lead to the development of psychotic disorders, such as schizophrenia, in adolescence.

Health - Pharmacology - 31.05.2021
Moving one step closer to personalized anesthesia
Moving one step closer to personalized anesthesia
Researchers have developed a device that can continuously measure the blood concentration of propofol - one of the main compounds used in anesthetics - in patients as they're being operated on. That will help anesthesiologists deliver more personalized doses. Anesthesia may be an exact science, but it's not yet fully personalized.

Pharmacology - Health - 31.05.2021
Diabetes remission diet lowers blood pressure and reduces need for medication
New research has shown that if people achieve and maintain substantial weight loss to manage their type 2 diabetes, many can also effectively control their high blood pressure and stop or cut down on their anti-hypertensive medication. A weight management programme, developed by researchers at the Universities of Glasgow and Newcastle for the Diabetes UK-funded DIabetes REmission Clinical Trial (DIRECT), has proved effective at lowering blood pressure and reducing the need for anti-hypertensive medications, as well as bringing remission of type 2 diabetes.

Health - Pharmacology - 28.05.2021
Pioneering single-dose radiotherapy for breast cancer treatment
Pioneering single-dose radiotherapy for breast cancer treatment
A breast cancer therapy that requires just one shot of radiotherapy is as effective as traditional radiotherapy, and avoids potential damage to nearby organs, according to a paper by UCL experts. The results, published in the British Journal of Cancer, mean that eight out of ten patients who receive the treatment, TARGIT-IORT, will not need a long course of post-operative external beam radiotherapy (EBRT).

Health - Pharmacology - 27.05.2021
Cell encapsulation could enhance antiviral vaccines
Cell encapsulation could enhance antiviral vaccines
A team from the UNIGE and the HUG has developed a new and effective anti-viral vaccination technique based on the cell encapsulation. Immunotherapy techniques developed in oncology to combat cancerous cells have great potential for fighting viruses. A research team from the University Hospitals of Geneva (HUG) and the University of Geneva , in Switzerland, in collaboration with MaxiVAX, a spinoff of both institutions, developed an innovative technology called "cell encapsulation".

Pharmacology - 27.05.2021
Switching off heart protein could protect against heart failure
Switching off heart protein could protect against heart failure
Switching off a heart muscle protein could provide a new way for drugs to combat heart failure in people who've had a heart attack, according to research led by the University of Cambridge and published in the journal Nature . After years of research we've revealed an entirely new and promising way that could help the recovery of failing hearts Xuan Li There is an unmet need to find drugs that can successfully improve the heart's ability to pump blood efficiently after it's been damaged following a heart attack.

Economics / Business - Pharmacology - 27.05.2021
Executives wildly overestimate financial benefits of strategy planning
Executives wildly overestimate financial benefits of strategy planning
New research shows executives are likely to overestimate the financial benefits of strategy planning - as conducted by an overwhelming majority of large companies - by a factor of five. Executives at 88% of large companies engage in strategy planning, according to the research featured in a chapter of " Focus: How to Plan Strategy and Improve Execution to Achieve Growth ,” a new book co-authored by Vikas Mittal , professor of marketing at the Rice's Jones Graduate School of Business, and Shrihari Sridhar , professor of marketing at Texas A&M University's Mays Business School.

Health - Pharmacology - 25.05.2021
New insight into when CAR T is effective against childhood leukaemia
Scientists and clinicians at UCL and Great Ormond Street Hospital (GOSH) studying the effectiveness of CAR T-cell therapies in children with leukaemia, have discovered a small sub-set of T-cells that are likely to play a key role in whether the treatment is successful. Researchers say 'stem cell memory T-cells' appear critical in both destroying the cancer at the outset and for long term immune surveillance and exploiting this quality could improve the design and performance of CAR T therapies.

Health - Pharmacology - 25.05.2021
Focus on life-threatening fungal infections
Focus on life-threatening fungal infections
Collaborative Research Center granted DFG funding for a further four years. The German Research Foundation (DFG) will fund the Collaborative Research Center/Transregio (CRC/TR) "FungiNet" for four more years with approximately ten million Euro. In the only CRC studying human pathogenic fungi, scientists in Jena and Würzburg will investigate infection processes and novel therapeutic options.