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Pharmacology - Health - 12.12.2018
Alzheimer’s drug may help battle antibiotic resistance
Dangerous antibiotic-resistant bacteria could soon be targeted with a drug initially developed to treat Alzheimer's disease.

Pharmacology - Health - 10.12.2018
Sandoz Inc. and Pear Therapeutics Obtain FDA Clearance for reSET-O(TM) to Treat Opioid Use Disorder
ReSET-O TM is the first FDA-cleared Prescription Digital Therapeutic (PDT) for patients with Opioid Use Disorder Pear Therapeutics is leading the development of a new therapeutic class with two FDA-a

Health - Pharmacology - 10.12.2018
Ucla
University News Rev. James Lawson Jr., civil rights icon, champion of nonviolence, receives UCLA Medal Arts + Culture Historian helps create archive at UCLA of South African propaganda comics from th

Health - Pharmacology - 08.12.2018
Novartis data demonstrates consistent efficacy and tolerability of Kisqali combination therapy in HR+/HER2- advanced breast cancer in patients with difficult-to-treat visceral disease
  Subgroup analyses of three pivotal Phase III MONALEESA trials showed Kisqali plus endocrine therapy extended PFS in all patients with and without visceral involvement compared to endocrine therapy

Life Sciences - Pharmacology - 07.12.2018
Dandelion rubber gets ready for the market
Dandelion rubber gets ready for the market
Research done by Prof. Dirk Prüfer and his team makes transfer possible / "Taraxagum project is an outstanding example of the way that Münster University stands for top-level research" Years ago, the idea sounded anything from weird to audacious: manufacturing car tyres from dandelions.

Pharmacology - Health - 07.12.2018
FDA approves Roche’s Tecentriq in combination with Avastin and chemotherapy for the initial treatment of people with a specific type of metastatic lung cancer
Approval based on survival benefit of Tecentriq in combination with Avastin, paclitaxel and carboplatin (chemotherapy) in people with metastatic non-squamous non-small cell lung cancer (NSCLC) with n

Astronomy / Space Science - Pharmacology - 06.12.2018
Blast off for first UK-led experiment on the International Space Station
UK-led research is taking place on the International Space Station (ISS) for the first time, following a successful launch from Kennedy Space Centre at Cape Canaveral in the US. An experiment using microscopic nematode worms involving teams of scientists from the Universities of Nottingham, Exeter and Lancaster was among a shipment of cargo and scientific investigations to be delivered to the ISS by the SpaceX Dragon spacecraft following the launch by the SpaceX Falcon 9 rocket at 6.16 pm (UK time) on Wednesday 5 December.

Health - Pharmacology - 05.12.2018
Roche’s Kadcyla cut the risk of disease recurring by half compared to Herceptin in people with HER2-positive early breast cancer with residual disease after neoadjuvant treatment
At three years, 88.3% of people treated with Kadcyla in the adjuvant HER2-positive early breast cancer setting did not have their breast cancer return compared to 77.0% treated with Her

Life Sciences - Pharmacology - 05.12.2018
CMU Welcomes New Head of Chemical Engineering
Internationally renowned researcher Anne Skaja Robinson has joined Carnegie Mellon University as head of its Department of Chemical Engineering.

Pharmacology - Health - 05.12.2018
FDA grants priority review to Roche’s Tecentriq in combination with chemotherapy for the initial treatment of extensive-stage small cell lung cancer
Roche today announced that the US Food and Drug Administration (FDA) has accepted the company's supplemental Biologics License Application (sBLA) and granted Priority Review for Tecentriq (atezolizum

Pharmacology - Health - 04.12.2018
Novartis advances ligelizumab (QGE031) in urticaria to Phase III on basis of strong Phase II head-to-head data
PEARL 1 and PEARL 2, the largest pivotal trials to date in chronic spontaneous urticaria (CSU), will enroll more than 2,000 CSU patients ,   Ligelizumab (QGE031), a monoclonal antibody, is being deve

Pharmacology - Health - 04.12.2018
New Venclexta/Venclyxto data demonstrate deep responses in two of the most common types of leukaemia
New analyses from the phase III MURANO study in previously treated chronic lymphocytic leukaemia show continued benefit from fixed-duration regimen after a median follow-up of three years Updated res

Pharmacology - Health - 03.12.2018
Roche’s Hemlibra provided sustained bleed control in the largest pivotal study to date of children with haemophilia A with factor VIII inhibitors
Nearly 77% of children receiving Hemlibra once weekly experienced zero treated bleeds Hemlibra once weekly reduced treated bleeds by 99% compared to prior bypassing agents in a prospective intra-pati

Pharmacology - Health - 03.12.2018
Longer-term follow-up data demonstrate sustained benefit of polatuzumab vedotin-based treatment in relapsed or refractory diffuse large B-cell lymphoma
Polatuzumab vedotin in combination with MabThera/Rituxan (rituximab) plus bendamustine more than doubled overall survival, compared to MabThera/Rituxan plus bendamustine alone in the phase Ib/II GO29365 study Polatuzumab vedotin has the potential to provide a promising new treatment option at first relapse Results from the GO29365 study, the first and only randomised study to suggest a survival benefit for patients not eligible for a haematopoie

Pharmacology - Health - 03.12.2018
Novartis announces FDA filing acceptance and Priority Review of AVXS-101, a one-time treatment designed to address the genetic root cause of SMA Type 1
The AVXS-101, now known as ZOLGENSMA (onasemnogene abeparvovec-xxxx) , filing is supported by data from the START trial which demonstrated a dramatic increase in survival and transformative improvement in achievement of developmental milestones compared to the natural history of SMA Type 1   SMA Type 1 is a progressive neuromuscular disease and the leading cause of genetic mortality in infants globally   ZOLGENSMA represents the first in a propr

Health - Pharmacology - 02.12.2018
Real-world data show Novartis drug Revolade improves outcomes for ITP patients compared to other second-line therapies
Revolade (eltrombopag) showed lower rate of bleeding-related episodes and similar rate of thrombotic events vs.

Health - Pharmacology - 01.12.2018
Novartis announces longer-term analyses from pivotal Kymriah trials that showed durable responses are maintained in patients with advanced blood cancers
In the updated analysis from ELIANA, Kymriah demonstrated an 82% remission rate within 3 months in pediatric patients with r/r ALL; relapse-free survival was 62% at 24 months, with median duration of

Pharmacology - Health - 01.12.2018
Novartis announces new crizanlizumab (SEG101) data analysis in sickle cell disease, and investment in SENTRY clinical program
New post-hoc analysis of SUSTAIN study, presented at ASH 2018, highlights results among patients who were treated per protocol compared with all randomized patients Crizanlizumab, a monthly infusion

Health - Pharmacology - 30.11.2018
Brexit clay and humanitarian solutions: News from the College
Here's a batch of fresh news and announcements from across Imperial. From a geological Brexit study captured in clay, to student solutions to global humanitarian aid challenges, here is some quick-read news from across the College.

Pharmacology - Health - 29.11.2018
Disrupting Opioid Addiction
Students Aim To Create Preemptive Tool To ID High-risk Users Carnegie Mellon University students have created a new tool to help clinicians identify individuals with high-risk patterns of opioid use before it's too late.

Pharmacology - Health - 29.11.2018
Novartis announces EU approval of Gilenya for children and adolescents with MS, making it the first and only oral disease-modifying treatment for these patients in Europe
Approval based on landmark PARADIGMS study showing Gilenya (fingolimod) significantly reduced relapse rates by 82% vs interferon beta-1a; additionally, 85.7% of Gilenya patients were relapse-f

Health - Pharmacology - 23.11.2018
Novartis announces landmark EU approval for one-time gene therapy Luxturna to restore vision in people with rare inherited retinal disease
Luxturna* (voretigene neparvovec) is the first gene therapy to treat an inherited retinal disease, indicated for children and adults with vision loss caused by mutations in both copies of the RPE65 g

Health - Pharmacology - 23.11.2018
Nutrients being trialled to manage OCD
University of Queensland researchers are conducting the Queensland trial of a new treatment for Obsessive-Compulsive Disorder (OCD) using an amino acid supplement.

Health - Pharmacology - 22.11.2018
Humpback whale songs simplified during ’cultural revolutions’
Humpback whales sing increasingly complex songs, but University of Queensland researchers have discovered they may suddenly switch to something simpler, in a ‘cultural revolution'.

Physics - Pharmacology - 21.11.2018
The Romeo and Juliet of particle physics comes to Lakeside
When Shakespeare and science collide - that's the essence of a new opera coming to Nottingham Lakeside Arts' Djanogly Theatre on University Park on Tuesday 27 November 2018.

Health - Pharmacology - 20.11.2018

Health - Pharmacology - 20.11.2018
New immunotherapy improves MS symptoms
A world-first clinical trial of a new cellular immunotherapy for multiple sclerosis (MS) has improved symptoms and quality of life for the majority of patients. The treatment targets the Epstein-Barr virus (EBV), and is based on a theory formulated by University of Queensland and Royal Brisbane and Women's Hospital (RBWH) researcher Professor Michael Pender.

Pharmacology - Health - 20.11.2018
Sandoz and Pear Therapeutics announce launch of reSET for treatment of patients with Substance Use Disorder
ReSET is the first and only FDA-authorized prescription digital therapeutic for Substance Use Disorder (SUD) Adding reSET to outpatient therapy significantly improved abstinence in substances of abus

Health - Pharmacology - 19.11.2018
Imaging project launched to transform treatment of kidney disease
A research team led by the University of Nottingham, has been awarded a grant by the the Medical Research Council (MRC) to enable the clinical translation of renal imaging and transform the way kidney disease is diagnosed and treated.

Health - Pharmacology - 19.11.2018
Fexinidazole - First All-Oral Treatment for Sleeping Sickness Approved
Fexinidazole - First All-Oral Treatment for Sleeping Sickness Approved
The European Medicines Agency's Committee for Medicinal Products for Human Use has adopted a positive opinion of fexinidazole, the first all-oral treatment that has been shown to be efficacious for both stages of sleeping sickness.

Health - Pharmacology - 19.11.2018
$2.5m to develop better skin treatments
Two projects to develop effective topical medicines have won almost $2.5 million ($US1.75) in US Food and Drug Administration grants.

Pharmacology - Health - 16.11.2018
FDA approves Novartis drug Promacta for first-line SAA and grants Breakthrough Therapy designation for additional new indication
Promacta receives FDA approval for first-line treatment of severe aplastic anemia (SAA) and Breakthrough Therapy designation for low platelet counts in people exposed to radiation   Approval based on compelling benefit established through complete response rates among SAA patients when Promacta is added to standard immunosuppressive therapy relative to historic information on that therapy alone   Promacta is the first new treatment in decades fo

Health - Pharmacology - 16.11.2018
Novartis receives positive CHMP opinion to expand Kisqali combination therapy to all women with HR+/HER2- locally advanced or metastatic breast cancer
Novartis receives positive CHMP opinion to expand Kisqali combination therapy to all women with HR+/HER2- locally advanced or metastatic breast cancer Kisqali is the CDK4/6 inhibitor with the largest body of first-line evidence demonstrating consistent, superior and sustained efficacy vs.

Pharmacology - Life Sciences - 16.11.2018
Non-antibiotic drugs also speed up the spread of antibiotic resistance
Non-antibiotic drugs also speed up the spread of antibiotic resistance
New research from The University of Queensland has found non-antibiotic pharmaceuticals can significantly promote the spread of antibiotic resistance via bacterial mating.

Health - Pharmacology - 16.11.2018
New study aims to reduce the use of oral antibiotics for ear infections in children
Middle ear infections, known medically as acute otitis media (AOM), are common painful infections in children, for which there are up to three million treatment episodes in England and Wales each year.

Health - Pharmacology - 13.11.2018
Six things doctors would like you to know about antibiotics
Every day healthcare workers around the world are waging war, in what is becoming the fight of our lives.

Pharmacology - Health - 13.11.2018
FDA grants priority review to Roche’s Tecentriq in combination with Abraxane for the initial treatment of people with PD-L1-positive, metastatic triple-negative breast cancer
Triple-negative breast cancer is an aggressive disease, with high unmet medical need If approved, this Tecentriq (atezolizumab) combination would be the first cancer immunotherapy regimen for the treatment of PD-L1-positive, metastatic triple-negative breast cancer Roche today announced the US Food and Drug Administration (FDA) has accepted the company's supplemental Biologics License Application (sBLA) and granted Priority Review for Tecentriq

Health - Pharmacology - 12.11.2018
Annual amnesty to tackle antibiotic resistance
Staff and students at Imperial are being encouraged to hand over their unused antibiotics as part of an annual amnesty.

Health - Pharmacology - 11.11.2018
New Novartis study supports Entresto as foundational HFrEF therapy and in-hospital initiation in appropriate stabilized heart failure patients
Entresto (sacubitril/valsartan) outperformed commonly used heart failure medicine enalapril in landmark study; delivered significantly greater and more rapid reductions in an established biomarker fo

Pharmacology - Health - 09.11.2018
Federal authorities launch a campaign to promote appropriate use of antibiotics
Bern, 09.11.2018 - Maintaining the effectiveness of antibiotics for humans and animals, and combating resistance - these are the two main objectives of the national Strategy on Antibiot

Health - Pharmacology - 08.11.2018
£438 million investment for UCL gene therapy spinouts
£438 million investment for UCL gene therapy spinouts
Prospective students Current students UCL spinout Orchard Therapeutics, a biotechnology company dedicated to transforming the lives of patients with rare disorders through innovative gene therapies, has raised $225 million (£173 million) through its initial public offering.

Pharmacology - Health - 05.11.2018
Novartis R&D update highlights industry leading development pipeline including potential blockbusters and advanced therapy platforms
26 potential blockbusters in confirmatory development. 13 projects in clinical development across Cell, Gene & Radioligand therapies.

Health - Pharmacology - 05.11.2018
Research will help to reduce limbo for cancer patients in the UK
A simple test to improve treatment for breast cancer patients invented by scientists in Nottingham could soon benefit people across the UK, as part of a £14 million national initiative.

Pharmacology - Health - 02.11.2018
Novartis data at ASH and SABCS show strength of pipeline and portfolio in hematology and oncology
Additional analysis from pivotal Phase III SOLAR-1 clinical trial studying investigational alpha-specific PI3K inhibitor BYL719 (alpelisib) and fulvestrant in patients with PIK3CA-mutated HR+/HER2- a

Pharmacology - Health - 01.11.2018
Roche to present new data from its industry-leading haematology portfolio at the American Society of Hematology 2018 Annual Meeting
Ten medicines featured in over 70 abstracts, including 25 oral presentations Additional data from three pivotal studies of Hemlibra in people with haemophilia A, with or without factor VIII inhibitor