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Results 1151 - 1200 of 1582.

Health - Pharmacology - 30.07.2014
AstraZeneca and Roche announce a collaboration to develop a diagnostic test for the treatment of lung cancer
AstraZeneca has announced a partnership with Roche to develop a plasma-based companion diagnostic test to support the development of AZD9291, a clinical stage compound to treat patients with non-small-cell lung cancer (NSCLC) who are resistant to initial treatment.

Health - Pharmacology - 29.07.2014
Novartis vaccine Bexsero sees high uptake in first large-scale public vaccination program to help protect against devastating meningitis B
Program in Québec's Saguenay-Lac-Saint-Jean region is the first public campaign globally to offer Bexsero to all from 2 months to 20 years of age More than 45,000 infants, young children and adolesce

Health - Pharmacology - 28.07.2014

Health - Pharmacology - 28.07.2014
Alcon’s Simbrinza approved in the EU to treat patients living with glaucoma, a chronic sight-threatening eye disease
Simbrinza provides a convenient option to reduce treatment burden versus concomitant administration of single drugs Simbrinza is the only beta blocker-free formulation combining two approved therapie

Pharmacology - Health - 24.07.2014
FDA accepts Sandoz application for biosimilar filgrastim
Sandoz is the first company to announce it has filed for approval of a biologic under the biosimilars pathway created in the Biologics Price Competition and Innovation Act of 2009 (BPCIA).

Pharmacology - Business / Economics - 17.07.2014
Novartis maintained strong innovation momentum in second quarter, while reconfirming full year outlook
Net sales grew 2% in Q2, with core operating leverage across Q2 and H1 Net sales of USD 14.6 billion grew 2% (+2% cc ) in Q2; USD 28.7 billion (+2%, +2% cc) in H1 Strong operating income

Health - Pharmacology - 15.07.2014
Novartis to license Google "smart lens" technology
Innovative technology offers potential to transform eye care and further enhance Alcon's leadership in contact lenses and intraocular lenses Agreement is a first step for Novartis to evolve technolog

Pharmacology - Health - 15.07.2014
Novartis announces collaboration with Banner Alzheimer’s Institute on a pioneering prevention study for Alzheimer’s Disease
Two Novartis anti-amyloid investigational treatments will be studied in people with a genetic risk of developing Alzheimer's Disease (AD) The build-up of amyloid in the brain is believed to be a crit

Health - Pharmacology - 09.07.2014
Novartis announces NEJM publication of two phase III studies demonstrating high efficacy of secukinumab (AIN457) in psoriasis patients
Results of two phase III psoriasis studies consistently show rapid, very high skin clearance, sustained efficacy and an acceptable safety profile with secukinumab More than 70% of secukinumab 300 mg patients experienced clear (PASI 100) or almost clear skin (PASI 90) during the first 16 weeks of treatment[ 1] If approved, secukinumab could address a high unmet need for new psoriasis treatments, as up to 50% of patients are dissatisfied with curr

Pharmacology - Health - 08.07.2014
Novartis reinforces its leadership in research with new global guidelines for Investigator Initiated Trials (IITs)
Novartis committed to support ethical clinical research; new global guidelines emphasizing the principles of ethics, governance and transparency Clinical research conducted by qualified independent investigators is an important part of drug discovery and development and can help explore unmet medical needs New guidelines reinforce requirement that no commercial funding, involvement or influence are permitted in any aspect of IITs Basel, July 8, 2014 - Novartis released today new global guidelines for Investigator Initiated Trials (IITs).

Health - Pharmacology - 07.07.2014
Novartis personalized cell therapy CTL019 receives FDA Breakthrough Therapy designation
Designation supports the advancement of CTL019 to help address the unmet need of patients with relapsed/refractory acute lymphoblastic leukemia (r/r ALL) The filing was submitted by the University of

Pharmacology - Health - 07.07.2014
Roche acquires Seragon Pharmaceuticals and their portfolio in breast cancer
Genentech, a member of the Roche Group, has entered into a definitive agreement to acquire Seragon Pharmaceuticals, which was spun out of Aragon Pharmaceuticals in August 2013 when the latter was bought by Johnson & Johnson for as much as $1 billion.

Pharmacology - Health - 30.06.2014
Roche partners with Versant Ventures to discover novel therapies for multiple sclerosis
Roche has entered a partnership with Inception Sciences (a drug discovery incubator backed by Versant Ventures) to create Inception 5, a new company dedicated to the research and development of novel small molecule remyelinating therapies for patients with multiple sclerosis, an autoimmune-mediated disease of the central nervous system.

Pharmacology - Health - 30.06.2014
Sandoz joins forces with United Nations to combat a leading cause of child mortality worldwide
Sandoz makes long-term commitment to support UN initiative on child mortality Commitment to UN Every Newborn Action Plan involves development and supply of recommended WHO formulation for treating ch

Pharmacology - Health - 23.06.2014
BIND Therapeutics and Roche collaborate on discovery of novel nanomedicines
BIND Therapeutics announced that it has entered into a research agreement with Roche to discover novel nanomedicines. The revolutionary clinical-stage nanomedicine platform company develops targeted and programmable therapeutics called Accurins. Accurins are polymeric nanoparticles that incorporate a therapeutic payload and are designed to have prolonged circulation within the bloodstream, enable targeting of the diseased tissue or cells, and provide for the controlled and timely release of the therapeutic payload.

Health - Pharmacology - 18.06.2014
Novartis emphasizes new focused portfolio at its first Meet Novartis Management investor day
New Novartis focused on three leading businesses with innovation power and global scale Pharmaceuticals building business depth in Dermatology, Heart Failure, Respiratory and Cell Therapy, complement

Pharmacology - Health - 17.06.2014
Novartis submits application to the FDA for meningitis B vaccine candidate Bexsero
Submission follows receipt of Breakthrough Therapy designation in April 2014, highlighting unmet need for a licensed vaccine for serogroup B in the US Meningitis B is a rare but aggressive disease th

Pharmacology - Health - 16.06.2014
Novartis Holly Springs facility becomes first US pandemic-ready site licensed by the FDA to produce cell-culture influenza vaccines
Cell-culture technology is a modern alternative to manufacture influenza vaccines without chicken eggs, with potential to rapidly respond to a pandemic Flucelvax , an FDA-approved antibioticand prese

Health - Pharmacology - 10.06.2014
Novartis Foundation for Sustainable Development to work with Netherlands Leprosy Relief to help reduce leprosy transmission
Collaboration to provide evidence on the impact of preventatively treating high risk groups to reduce the transmission of leprosy in several countries across Asia, Africa and Latin America Research s

Pharmacology - Health - 03.06.2014
Pivotal Phase III data show polycythemia vera patients on Novartis drug Jakavi achieved significant improvement in disease control
77% of patients on Jakavi (ruxolitinib) vs 20% on best available therapy achieved hematocrit control or spleen reduction, key treatment goals in PV Nearly half of ruxolitinib-treated patients had a 5

Health - Pharmacology - 02.06.2014
Zykadia(TM) shrank tumors in the majority of patients with ALK+ NSCLC, regardless of prior ALK treatment
Ceritinib achieved overall response rate of 58.5%, with a median progression-free survival of 8.2 months Similar findings were observed in patients who started the study with brain meta

Pharmacology - Health - 02.06.2014
Novartis data at ASCO show LBH589 significantly improved progression-free survival in patients with multiple myeloma
Results show adding LBH589 to bortezomib and dexamethasone significantly improved PFS by 37%, meeting Phase III study primary endpoint Median PFS increased by 4 months (12 months in LBH589 arm versus 8 months in placebo arm) ; effect of LBH589 observed across all patient subgroups Most people with multiple myeloma will relapse or become refractory; if approved, LBH589 will be first in its class of anticancer agents available to this population B

Pharmacology - Health - 02.06.2014
Roche acquires Genia Technologies to strengthen next generation sequencing pipeline
Roche acquires Genia Technologies to strengthen next generation sequencing pipeline Roche announced today the acquisition of Genia Technologies, Inc.

Health - Pharmacology - 01.06.2014
Pivotal data for Novartis’ investigational compound LDE225 show marked tumor responses in advanced basal cell carcinoma
The study met the primary endpoint with objective response rates of 41.8% and 32.5% respectively in the 200 mg and 800 mg treatment arms , Basal cell carcinoma is the most common form o

Pharmacology - Life Sciences - 28.05.2014
World MS Day: Novartis launches 7-Day Challenge to ’Live Like You’ enabling people with MS to better understand their lives with MS
7-Day Challenge integrates wearable technology and social media to track daily activities of people with MS, allowing valuable personal insights to enable change Novartis is collaborating with Tictra

Health - Pharmacology - 23.05.2014
Alcon receives positive CHMP opinion for Simbrinza , a new fixed-dose combination medicine to treat patients with glaucoma
Simbrinza reduced intraocular pressure in two Phase III studies by 23%-34%, 25%-37% respectively, providing strong efficacy, sustained control throughout the day Only beta blocker-free, fixed-dose co

Health - Pharmacology - 23.05.2014
Novartis provides update on EU marketing authorization application for RLX030 in acute heart failure
CHMP confirms negative opinion following re-examination of RLX030 - further evidence is required Novartis aims to resubmit for approval with data from ongoing second Phase 3 study (RELAX-AHF-2) Basel, May 23, 2014 - Novartis announced today that the Committee for Medicinal Products for Human Use (CHMP) has adopted a negative opinion for the use of RLX030 (serelaxin) in the treatment of acute heart failure (AHF) indicating that further evidence is required for a license to be granted in the EU.

Pharmacology - Health - 22.05.2014
Novartis presents key advances in cancer research at ASCO and EHA from four new pivotal studies in lung, blood and skin cancers
Pivotal data in ALK+ NSCLC for Zykadia(TM); recently approved by US FDA, marking fastest oncology approval under Breakthrough Therapy designation First presentation of pivotal data from Phase III tri

Health - Pharmacology - 21.05.2014
Novartis announces positive results at ATS for once-daily Ultibro Breezhaler versus combination therapy (tiotropium plus formoterol)
QUANTIFY study met primary endpoint demonstrating non-inferiority of Ultibro Breezhaler vs tiotropium 18 mcg plus formoterol 12 mcg in improving health-related quality of life outcomes , QUANTIFY stu

Pharmacology - Health - 19.05.2014
Novartis announces exclusive agreement to extend leadership in ophthalmology, leveraging novel anti-PGDF therapy Fovista
Novartis acquires exclusive ex-US rights to Fovista from Ophthotech; upfront payment of USD 200 million plus potential future recruitment and other milestone payments; additionally Ophthotech to rece

Pharmacology - Health - 16.05.2014
FDA issues Complete Response Letter for RLX030 for acute heart failure
Agency states further evidence of the efficacy of RLX030 is required for US approval Second phase III study RELAX-AHF-2 progressing well - Novartis intends to resubmit NDA with additional data when available Basel, May 16, 2014 - Novartis announced today that the US Food and Drug Administration (FDA) has issued a Complete Response Letter (CRL) regarding the Biologics License Application (BLA) for RLX030 (serelaxin) for the treatment of acute heart failure (AHF), stating that further evidence on the efficacy of RLX030 is required for a US license to be granted.

Pharmacology - Innovation - 15.05.2014
Novartis settles patent litigation on Gleevec (imatinib mesylate) with Sun Pharma subsidiary
Litigation settlement upholds validity of US patents covering polymorphic forms of Gleevec and permits Sun Pharma subsidiary to launch a generic version on February 1, 2016 Patents are vital to the a

Pharmacology - Health - 09.05.2014
Novartis data at ARVO 2014 confirm transformational real world outcomes and highlight the safety profile of Lucentis
LUMINOUS, the largest ongoing trial in medical retina, presented 1-year results on the effectiveness and safety profile of Lucentis in patients with wet AMD COMRADE-B study indicates BRVO patients treated with Lucentis had significantly higher vision gains at month 6 compared with dexamethasone New real-world data demonstrates significant differences in rates of endophthalmitis with aflibercept and Lucentis Basel, May 9, 2014 - Novartis reports

Health - Pharmacology - 05.05.2014
Novartis drug Signifor LAR shows superior efficacy in acromegaly patients
Acromegaly, an endocrine disorder resulting from elevated growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels, is associated with high mortality[1,2] Phase III data show patients on p

Health - Pharmacology - 30.04.2014
Novartis once-daily Ultibro Breezhaler showed superior efficacy versus Seretide * for COPD patients
Ultibro Breezhaler demonstrated superiority in lung function compared to Seretide Accuhaler * in chronic obstructive pulmonary disease ( COPD) patients with or without exacerbations in the previous year Primary and key secondary objectives met in pivotal Phase III LANTERN study Positive results to be part of the regulatory submission for Ultibro Breezhaler in China later this year Basel, April 30, 2014 - Novartis today announced positive first r

Pharmacology - Health - 30.04.2014
Novartis announces presentation of data at AAN showing Gilenya slowed the rate of brain volume loss in MS patients
MS patients have accelerated brain volume loss (up to 3-5 times faster than people without MS), which is associated with physical & cognitive loss of function Data at AAN showed significantly more Gilenya-treated patients (vs.

Health - Pharmacology - 29.04.2014
Novartis gains FDA approval for Zykadia(TM), first therapy for patients with ALK+ NSCLC previously treated with the ALK inhibitor crizotinib
Zykadia (ceritinib) demonstrated an overall response rate of 54.6% in patients with ALK+ metastatic NSCLC who have no other treatment option Median duration of response to Zykadia was 7&period

Health - Pharmacology - 29.04.2014
CHMP recommends EU label expansion of Novartis’ Gilenya and data at AAN confirm efficacy on pre-treated MS patients
CHMP has recognized Gilenya's favorable benefit/risk profile and recommends EU label expansion to patients not responding to DMTs beyond interferon AAN data: Gilenya reduces relapse rates, new MRI lesion counts, brain volume loss & disability progression in pre-treated MS patients with high disease activity Gilenya is the only oral DMT that is effective across four key measures of MS (relapse rates, MRI lesions, brain volume loss and disabil

Health - Pharmacology - 25.04.2014
FDA Approves Roche’s HPV Test for First-Line Primary Screening for Cervical Cancer
FDA Approves Roche's HPV Test for First-Line Primary Screening for Cervical Cancer Expanded indication makes cobas HPV Test the only test approved in U.S. that can be used instead of Pap in first-line primary screening in women 25 and older Roche announced today that the U.S. Food and Drug Administration (FDA) approved the cobas HPV (Human Papillomavirus) Test for use as a first-line primary screening test for cervical cancer in women 25 and older.

Health - Pharmacology - 25.04.2014
Novartis’ INSTEAD study for Onbrez Breezhaler in patients with moderate COPD meets primary objective
Results confirm non-inferiority of Onbrez Breezhaler (indacaterol) in lung function compared to Seretide * (salmeterol/fluticasone) in the studied population In INSTEAD study, patients with moderate COPD and no exacerbations in the past year were switched from salmeterol/fluticasone to Onbrez Breezhaler Study showed similar symptomatic benefits in terms of shortness of breath and health status in patients treated with Onbrez Breezhaler compared

Business / Economics - Pharmacology - 24.04.2014
Novartis delivered solid sales and profit growth in the first quarter of 2014
Net sales of USD 14.0 billion up 1% (+3% cc ) with all divisions contributing to growth (cc); core operating leverage (cc) driven by Pharmaceuticals and lower Corporate costs Operating income

Pharmacology - Health - 23.04.2014
New data at AAN to confirm efficacy of Novartis’ Gilenya across four key measures of MS disease activity, including brain volume loss
Gilenya reduced relapse rates, new MRI lesion counts, brain volume loss and disability progression in previously-treated MS patients with high disease activity Data at AAN showed significantly more Gilenya-treated patients (vs.

Business / Economics - Pharmacology - 22.04.2014
Novartis announces portfolio transformation
Acquires GSK oncology products, strengthening Novartis' leading Oncology business with novel therapies and becomes GSK's preferred commercialization partner for its oncology pipeline Combines Novarti

Pharmacology - Business / Economics - 09.04.2014
Novartis appoints Jeff George as Division Head, Alcon as Kevin Buehler retires; Richard Francis named as new Division Head, Sandoz
Basel, April 9, 2014 - Novartis announced today the appointment of Jeff George as Division Head of Alcon, effective May 1, 2014.

Health - Pharmacology - 07.04.2014
Novartis meningitis B vaccine Bexsero receives FDA Breakthrough Therapy designation in the US
The designation highlights the potential of Bexsero to meet the urgent need for a licensed vaccine in the US against unpredictable and devastating meningitis B Bexsero, already approved in Europe, Ca

Health - Pharmacology - 07.04.2014
Novartis and Malaria No More provide two million antimalarial treatments to children in Zambia
One million antimalarial treatments donated by Novartis, matching one million treatments funded through Malaria No More's Power of One campaign Power of One enables the public to fund malaria tests a

Pharmacology - Health - 03.04.2014
Novartis data on 19 compounds at AACR highlight strong cancer pipeline across multiple molecular targets and biological pathways
More than 50 abstracts highlight breadth and depth of Novartis Oncology pipeline and ability to test various combinations early to target multiple pathways Data show activity of investigational compo

Pharmacology - Health - 31.03.2014
PARADIGM-HF trial of Novartis’ LCZ696 for chronic heart failure closes early based on strength of interim results
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