“We found a patient’s response to the antibiotic improved significantly if the dosage was monitored and altered accordingly,” Dr Abdul-Aziz said.
The innovative guidelines were developed by 16 antibiotic experts from 11 different countries and recommended the use of advanced software to predict accurate drug dosages and generate personalised treatment regimens.
Dr Abdul-Aziz said more than 160,000 Australians required specialised care in ICU and 13 per cent of these patients died each year.
ICU patients requiring antibiotics commonly suffer vital organ failure from sepsis, pneumonia or infections from burns.
Dr Abdul-Aziz said monitoring equipment and training needed to be rolled-out before routine TDM can be adopted as the worldwide standard-of-care.
The study is part of the NHMRC-funded Centre of Research Excellent in Redefining Antimicrobial Use to Reduce Resistance (REDUCE).
This research is published in the journal, Intensive Care Medicine . (DOI: 10.1007/s00134-020-06050-1).