Every single cell counts - even before birth!

Prinz, Dr Fichtner and Ravens at the MHH Institute of Immunology. Copyright: Kar

Prinz, Dr Fichtner and Ravens at the MHH Institute of Immunology. Copyright: Karin Kaiser/ MHH.

Team of the RESIST Cluster of Excellence researches: Certain immune cells develop early in life and remain throughout life

Stand: 28.05.2021

Some things are particularly deeply rooted: for example, certain white blood cells of the adult immune system are already formed around the eighth week of pregnancy. These are gamma-delta T cells, more precisely theV‘9V’2+ T cells. They can recognise bacterial infections as well as tissue damage and changes, such as cancer, or act as inflammation-enhancing cells in autoimmune diseases. They are found in the blood, but also in the intestine, skin, liver and lungs.

Sarina Ravens and Dr. Alina Fichtner from the Institute of Immunology at the Hannover Medical School (MHH) and Immo Prinz and Dr. Likai Tan from the Institute of Systems Immunology at the University Medical Center Hamburg-Eppendorf (UKE) have been able to prove the early origin of these immune cells. They cooperate in the RESIST Cluster of Excellence led by the MHH and published their findings in the scientific journal "Science Immunology".

Gamma-delta T cells are named after the proteins on their surface (the T cell receptors) which enable them to recognise antigens. Each of these cells has an individual T-cell receptor, resulting in a highly diverse T-cell pool. "To study the diversity of gamma-delta T cells and their receptors, we developed an innovative high-throughput sequencing method based on the individual analysis of each cell," says Professor Ravens.

Using this technology, the team studied gamma-delta T cells in cord blood samples as well as from adult blood samples. "Interestingly, certain human V‘9V’2 T cells are generated exclusively in the very early phase of life to be ready for immediate use at the time of birth and afterwards to persist as innate immune cells throughout life in humans," reports Dr Fichtner.

Only recently, the team was able to show that certain gamma-delta T cells proliferate expansively directly after birth and they are thus very likely important for the early childhood immune system. "Now we want to find out where these highly functional and innate gamma-delta T cells are found in the body and what role they play in immune defence and autoimmune diseases," adds Professor Prinz. The long-term goal of the scientists is to create the basis for optimised preventive measures, diagnoses and therapies.

RESIST - Research for the Weakest

In the Cluster of Excellence RESIST (Resolving Infection Susceptibility), led by the MHH, about 50 research teams are working towards one goal: they want to make it possible for particularly vulnerable people to be better protected against infections, for example newborns. RESIST includes doctors who work in hospitals and are very familiar with the situation of patients, as well as basic scientists who research pathogens and their interaction with the immune system down to the smallest detail. RESIST consists of six partner institutions, the spokesperson is Thomas Schulz, head of the MHH Institute of Virology. RESIST is funded by the German Research Foundation (DFG). More information about RESIST can be found at www.RESIST-cluster.de
Ravens.Sarina @ mh-hannover.de and Professor Dr Immo Prinz, Prinz.Immo @ mh-hannover.de.

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