- Real-world evidence supports benefits seen in Aimovig clinical trials
- Open-label data highlight long-term efficacy and safety profile of Aimovig in episodic and chronic migraine
- Post-hoc and real-world data show preventive treatment with Aimovig significantly reduces need for acute medications
- These additional long-term data complement the position of Aimovig as the most prescribed anti-CGRP, with more than 350,000 patients prescribed worldwide since launch1
Basel, April 16, 2020 - Novartis today announced that clinical data for Aimovig (erenumab) was reported in Neurology. The data strengthens the role Aimovig as a preventive migraine treatment and confirms its real-world and long-term safety and efficacy benefit in patients with episodic and chronic migraine. The data were scheduled to be presented at the 2020 American Academy of Neurology Annual Meeting in Toronto on April 25-May 1, which was cancelled due to the current COVID-19 pandemic.
"These newly shared data reinforce Novartis commitment to reimagine migraine care and add to the growing body of real world and long-term evidence demonstrating the efficacy of Aimovig for migraine prevention across the migraine spectrum," said Estelle Vester-Blokland, Global Head Neuroscience Medical Affairs, Novartis Pharmaceuticals. "Novartis and Amgen are proud to lead the way based on the vast breadth of experience with Aimovig in showing how patients can take their life back from this highly debilitating disease."
Migraine is a highly debilitating disease that has a profound and limiting impact on peoples’ lives, including time spent with family and friends, or at work2,3. Aimovig, co-marketed in the US by Amgen and Novartis, is the first and only FDA-approved migraine preventive treatment that targets the calcitonin gene-related peptide (CGRP) receptor. It is self-administered once monthly via the SureClick autoinjector, does not require a loading dose and is easy to use4.
Interim exploratory results from the real-world TELESCOPE study, conducted with 109 patients in Germany, showed that 80% of patients taking Aimovig reported a reduction of migraine intensity and 92% had fewer attacks, with an average reduction of 8 monthly migraine days (MMD). Furthermore, interim results from the real-world PERISCOPE study in 19,740 migraine patients including 91 patients taking Aimovig with an overall mean disease duration of 18 years, also conducted in Germany, showed that 85% of patients taking Aimovig could cope better with daily activities. Importantly, 83% lost fewer days to migraine since starting the treatment.
Long-term Data in Episodic and Chronic Migraine
Results from a 4.5-year interim analysis of the open-label treatment phase of the Phase II clinical trial in patients with episodic migraine showed that long-term treatment with Aimovig resulted in sustained reductions in MMD. Patients with episodic migraine who switched from 70 mg to 140 mg and remained on 140 mg at