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Pharmacology - Health - 16.12.2020
Novartis investigational oral therapy iptacopan (LNP023) receives FDA Breakthrough Therapy Designation for PNH and Rare Pediatric Disease Designation for C3G
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and life-threatening blood disorder, resulting in debilitating symptoms that can impact patients' quality of life 1-3 C3 glomerulopathy (C3G) is a

Health - Pharmacology - 16.12.2020
Researchers call for people with mental illness to have top priority for COVID-19 vaccine
People with serious mental illness should be given priority access to a COVID-19 vaccine when one becomes available, say University of Queensland researchers. Studies show people with serious mental illness are more likely to be infected by the COVID-19 virus and have higher rates of hospitalisation due to medications, poorer general health, reduced access to medical care, lower socio-economic status, overcrowding, smoking and obesity.

Health - Pharmacology - 16.12.2020
New Scottish study to "REACH" people with heart failure at home
REACH-HF - is an award winning cardiac rehabilitation programme which helps people living with heart failure improve their quality of life from the comfort and safety of their own homes - is being rolled out in six NHS Scotland Health Boards from this month.

Pharmacology - Health - 16.12.2020
Novartis announces positive FDA Advisory Committee recommendation for use of Entresto to treat patients with HFpEF
The Committee voted 12 to 1 that the data presented support the use of Entresto in treatment of patients with heart failure with preserved ejection fraction (HFpEF) Potential Q1 2021 sNDA approval co

Health - Pharmacology - 15.12.2020
Vaccines must prevent infection, disease progression and transmission - in every country - to truly bring COVID-19 under control
An editorial co-authored by a member of the UK's influential SAGE committee that advises the UK Government on COVID-19, and published in Anaesthesia (a journal of the Association of Anaesthetists) sa

Health - Pharmacology - 15.12.2020
New synthetic molecule can kill the flu virus
New synthetic molecule can kill the flu virus
Scientists have developed a synthetic molecule capable of killing the virus that causes influenza. They hope their discovery will lead to an effective drug treatment.

Pharmacology - Health - 15.12.2020
Novartis reports positive topline results from second Phase III trial of Beovu in patients with diabetic macular edema
In Phase III KESTREL study, Beovu (brolucizumab 6 mg) achieved its primary endpoint of non-inferiority to aflibercept 2 mg in change in best-corrected visual acuity (BCVA) at year one (week 52) 1 In

Pharmacology - Health - 14.12.2020

Health - Pharmacology - 11.12.2020
No deal Brexit could have detrimental impact for four million people in UK living with a rare disease
Experts have warned that a 'no deal' Brexit will result in the exclusion of the UK from the 24 European Reference Networks (ERNs) that were established to improve the care of patients bearing the lifelong burden of a rare disease, which require highly specialised diagnosis and treatment.

Health - Pharmacology - 11.12.2020
Update on UQ COVID-19 vaccine
The University of Queensland and CSL today announce that the Phase 1 trial of the UQ-CSL v451 COVID-19 vaccine has shown that it elicits a robust response towards the virus and has a strong safety profile.

Health - Pharmacology - 11.12.2020
Roche launches laboratory SARS-CoV-2 antigen test to support high-volume testing of suspected COVID-19 patients
The Elecsys SARS-CoV-2 Antigen test is an automated laboratory assay intended as an aid in the diagnosis of active SARS-CoV-2 infection Roche will be able to ramp up to a double-digit million number

Health - Pharmacology - 10.12.2020
New Personalized Immunotherapy Trial Launched Despite COVID-19 Pandemic
First patient to receive individualized TIL therapy undergoes treatment at Moores Cancer Center Since 2016, Bernard Thurman has undergone traditional treatments, experimental therapies and surgeries to counter the cancer within him, but nothing successfully eradicated the disease.

Health - Pharmacology - 09.12.2020
Novartis Kisqali demonstrates nearly five years median overall survival in metastatic breast cancer
MONALEESA-7 median overall survival (OS) results reinforce Kisqali as the CDK4/6 inhibitor with un rivaled OS evidence 1 Kisqali plus endocrine therapy had a median OS of nearly five years (58&peri

Health - Pharmacology - 09.12.2020
Roche partners with Moderna to include SARS-CoV-2 antibody test in ongoing COVID-19 vaccine trials
Moderna's vaccine triggers an antibody response to the SARS-CoV-2 spike protein The Elecsys Anti-SARS-CoV-2 S test can quantitatively measure the level of antibodies against SARS-CoV-2 in vaccine tri

Research Management - Pharmacology - 09.12.2020

Pharmacology - Health - 08.12.2020
Novartis investigational STAMP inhibitor asciminib (ABL001) shows superior MMR rate to Bosulif * in chronic myeloid leukemia trial
At 24 weeks, asciminib nearly doubled the major molecular response (MMR) rate compared to Bosulif (bosutinib)*, in patients resistant to, or intolerant of, at least two prior tyrosine kinase inhibito

Pharmacology - Health - 08.12.2020
Roche presents new data from its bispecific antibody portfolio across a range of blood cancers
Latest data to be presented at ASH 2020 includes results in non-Hodgkin lymphoma and heavily pre-treated multiple myeloma Portfolio includes two CD20xCD3 bispecifics, mosunetuzumab and glofitamab, an

Pharmacology - Health - 05.12.2020
Novartis analyses confirm benefit of Kymriah with clinically meaningful rates of complete response seen in patients with certain advanced lymphomas
Interim analysis from the investigational ELARA study shows, 65% of patients with r/r follicular lymphoma evaluated for efficacy achieved a complete response and the overall response rate was 83% 1 L

Pharmacology - Health - 04.12.2020
Novartis announces first data from REACH3 trial showing Jakavi (ruxolitinib) significantly improved outcomes in patients with steroid-resistant/dependent chronic GvHD
Results of REACH3 trial also demonstrate significant improvements in failure-free survival (FFS) and patient-reported symptoms 1 Chronic graft-versus-host disease (GvHD) is a life-threatening complic

Health - Pharmacology - 04.12.2020
Glasgow at the forefront of paediatric Crohn’s Trials
A pilot Crohn's trial led by doctors at Glasgow's Royal Hospital for Children and scientists at the University of Glasgow has seen remarkable results with 60% of patients entering remission after just eight weeks, giving hope to patients across the country.

Health - Pharmacology - 04.12.2020
How new hospital benefited patients, staff in pandemic year
The 368-bed hospital building, which celebrates its one-year anniversary on Nov. 17, features technology and design features that have made handling COVID-19 cases easier.

Pharmacology - Health - 02.12.2020
Opinion: Designing Vaccines for People, Not Profits
There is still a long way to go to deliver on the promise of a universal, freely available "people's vaccine", argue Professor Mariana Mazzucato, Henry Lishi Li and Els Torreele (All UCL Institute for Innovation & Public Purpose).

Health - Pharmacology - 02.12.2020
Roche receives FDA Emergency Use Authorization for new test to measure the level of SARS-CoV-2 antibodies
Elecsys Anti-SARS-CoV-2 S test specifically detects antibodies against the SARS-CoV-2 spike protein The spike protein is the target of many COVID-19 vaccines in development This test may help identif

Health - Pharmacology - 30.11.2020
COVID-19: Fall in cancer treatment rose following ’rapid’ NHS guidance
The number of patients starting anticancer therapies dropped by more than 30 per cent in April, the month following the UK's first COVID-19 lockdown, but went above pre-pandemic levels within three months, finds a new study of NHS England data co-led by UCL researchers.

Health - Pharmacology - 30.11.2020
Taco mattresses take the pressure off hospitals
Taco mattresses take the pressure off hospitals
During the lockdown last spring, Julian Ferchow put his doctoral project aside to help relieve the strain on hospitals.

Health - Pharmacology - 25.11.2020
Opinion: Should Covid-19 vaccines be mandatory?
To be properly protective, Covid-19 vaccines need to be given to most people worldwide. Here, Dr Vageesh Jain (UCL Institute for Global Health) argues against the need for mandatory vaccines, while Dr Alberto Giubilini argues the reverse.

Health - Pharmacology - 25.11.2020
Re-starting global economy depends on tackling ’last mile’ of vaccine journey
Re-starting the global economy for billions of people will depend on successfully overcoming logistical challenges in the 'last mile' of a COVID-19 vaccine's journey to immunisation stations, according to a new report.

Health - Pharmacology - 25.11.2020
Infusion more effective than tablets: Treatment of iron anaemia in rural Africa
Infusion more effective than tablets: Treatment of iron anaemia in rural Africa
Iron-deficiency anaemia is a major concern in low income countries, especially for women. A study conducted in Tanzania has now demonstrated the advantage of iron infusion therapy over the usual treatment with iron tablets.

Health - Pharmacology - 25.11.2020
Tackling pandemic threats proactively
If we are to minimize the impact of future disease outbreaks, we must recognize the importance of immunization and invest in preemptive vaccine development, writes Tim Keys.

Pharmacology - Health - 20.11.2020
"high level" of COVID vaccine resistance
Almost three-in-five Australians (58.5 per cent) say they will definitely get a COVID vaccine once it is available, new analysis from The Australian National University (ANU) shows.

Health - Pharmacology - 19.11.2020
Bristol secures 45M to advance gene therapy treatment of chronic kidney diseases
The University of Bristol has secured a £45million deal to advance its groundbreaking gene therapy technology for chronic kidney diseases.
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