Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research
Maulbeerstrasse 66, 4058 Basel
Friedrich Miescher Institute for Biomedical Research   link
Location: Basel
Discipline: Health

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Life Sciences - Event - Sep 14
Life Sciences - Event
Due the covid-19 situation, we could not hold our FMI 50th Anniversary Symposium as planned. Instead, we organized a short video conference - for FMI members and our Scientific Advisory Board - to celebrate science virtually. The Award ceremonies for our three annual internal science prizes were at the heart of the meeting.
Health - Life Sciences - Sep 8
Health - Life Sciences

The FMI is a partner of the pan-European LifeTime initiative. In two publications, researchers involved with the initiative - including FMI group leader Susan Gasser - present a detailed roadmap of how to leverage the latest scientific breakthroughs and technologies over the next decade, to track, understand and treat human cells throughout an individual's lifetime.

Research Management - Career - Sep 3

FMI group leader Johannes Felsenberg is among this year's recipients of a prestigious Starting Grant from the European Research Council (ERC). He will use the grant to study the neural processes that allow memories to be changed, using the fruit fly Drosophila as a model organism.

Life Sciences - Jul 21
Life Sciences

The group of Helge Grosshans characterized the " C. elegans oscillator", over 3,700 genes that are rhythmically expressed during the larval development of C. elegans .

Life Sciences - Jun 22
Life Sciences

In a comprehensive study, researchers from the Rijli group found that a single Hox transcription factor expressed in a group of neurons of the pontine nucleus - the cerebral cortex most important brainstem relay to the cerebellum - determines the wiring onto these neurons of somatosensory cortical neurons, while avoiding visual cortical neurons.

Life Sciences - Jun 2

While the first genome-wide DNA methylation map in mammalian cells was established over 10 years ago, such maps only provide snapshots and do not inform about the actual dynamics of this epigenetic mark. Researchers from the Schübeler group now quantified actual rates of methylation and demethylation for 860,404 individual CpGs in mouse embryonic stem cells. Their study reveals highly variable and context-specific activity for the DNA methylation machinery.

Life Sciences - Event - Apr 28

FMI group leader Silvia Arber is among the 26 international members elected to the National Academy of Sciences (NAS) this year. Members are elected to the NAS in recognition of their distinguished and continuing achievements in original research. Membership is a widely accepted mark of excellence in science and is considered one of the highest honors that a scientist can receive.

Life Sciences - Health - Sep 7
Life Sciences - Health

Molecular glue degraders are a new class of drugs that work by facilitating an interaction between a disease-causing target protein and a ubiquitin ligase complex, tagging the target protein for degradation. In this new video, members of the Thomä group, in collaboration with the Broad Institute, explain how they identified and characterized a new molecular glue degrader compound called CR8, showing that it is unlike any of the previously identified molecular glue degraders.

Life Sciences - Chemistry - Aug 31
Life Sciences - Chemistry

Organoid? was launched today. It aims at validating organoids as faithful models of human biology, combining single-cell profiling and organoid technology.

Life Sciences - Chemistry - Jul 6
Life Sciences - Chemistry

The cytosolic iron sulfur assembly (CIA) pathway is required for the insertion of Fe-S clusters into proteins, including many DNA replication and repair factors. Despite its essential cellular function, this pathway remains enigmatic. A new integrative structural and biochemical study from the Thomä group now provides detailed insights into the mechanisms of Fe-S protein biogenesis.

Life Sciences - Jun 11
Life Sciences

In a video (5'35'') combining interviews and figures, the team behind the latest collaboration from the Thomä and Schübeler labs - Alicia Michael, Ralph Grand and Luke Isbel - explain how they developed an assay identifying where the preferable sites for the transcription factor-DNA binding motif on the nucleosome were, so that they could build transcription factor-nucleosome complexes.

Life Sciences - May 12
Life Sciences

The Peters group studies chromatin formation and regulation in mammalian germ cells and during early embryonic development. Now researchers from the group identified a novel pathway that is essential for maintaining the integrity of heterochromatin, and therefore for securing chromosome stability.

Life Sciences - Apr 24
Life Sciences

The Gasser group discovered that silencing of heterochromatic regions - and more specifically of hundreds of Polycomb-target genes enriched for H3K27me3 - can occur through selective RNA degradation, and not only through transcriptional repression. The study links the epigenetics state of a gene with the fate of its RNA transcript. It is the first time that this is shown in higher eukaryotes.

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