Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research
Basel
Friedrich Miescher Institute for Biomedical Research  
Discipline: Medicine/Pharmacology

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Life Sciences - May 22
Life Sciences
From yeast to man, the genome is partitioned into subnuclear compartments, with active euchromatin spatially separated from silent heterochromatin, which is often found at the nuclear periphery. This spatial distribution correlates with gene expression and contributes to cell-type integrity.
Life Sciences - Apr 25
Life Sciences

Intestinal organoids are three-dimensional structures derived from a single intestinal stem cell. They are great tools for applications ranging from fundamental biology to personalized and regenerative medicine.

Life Sciences - Apr 17
Life Sciences

Chromatin remodelers have the ability to move nucleosomes, which represent a physical barrier for access to DNA.

Life Sciences - Mar 25
Life Sciences

Puberty is a period of extensive changes of body morphology and function. As much as we are familiar with these life-altering changes, relatively little is known about what sets the whole process in motion.

Life Sciences - Mar 13

Five of our postdocs were recently awarded the prestigious EMBO and Maria Sklodowska-Curie Actions (MSCA) Fellowships. These grants are highly competitive and known worldwide for promoting innovative and interdisciplinary research.

Life Sciences - Feb 26
Life Sciences

The heterochromatin of eukaryotes contains repetitive DNA, which can lead to genome instability when transcribed.

Life Sciences - Apr 23
Life Sciences

Our actions are driven by “internal states” such as anxiety, stress or thirst - which will strongly affect and motivate our behaviors.

Life Sciences - Apr 8

Guillaume Diss joined the FMI as a new Quantitative Biology group leader on March 1. His research focuses on understanding the mechanisms whereby genetic variation translates into phenotypic variation - for example, in diseases.

Life Sciences - Mar 19
Life Sciences

Epigenetic memory of transcriptional gene silencing has been observed in several organisms. However, it was not known whether mechanisms exist that convey transgenerational memory of a silencing “experience”, without silencing the gene permanently.

Career - Mar 7

Susan Gasser, who has led the FMI for the past 15 years, has stepped down from her role as Director of the FMI, while she continues to lead her research team within the institute. Silvia Arber and Dirk Schübeler, FMI senior group leaders highly regarded for their scientific excellence and strong leadership skills, have been appointed co-directors of the FMI ad interim, from March 1st onwards.

Life Sciences - Feb 12
Life Sciences

The two ex-PhD students from the group of Georg Keller are recognized in the category "Neurosciences and Diseases of the Nervous System" for a study in which they shed light on neural circuits in the cortex that underlie the integration of movement and visual feedback.




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Medicine and Life Sciences