Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research
Basel
Friedrich Miescher Institute for Biomedical Research  
Discipline: Medicine/Pharmacology

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Life Sciences - Jul 21
Life Sciences
DNA has become the icon of modern bioscience but few people realize that it was Friedrich Miescher, who - almost a century before Watson and Crick - laid the chemical groundwork for the molecular breakthroughs that followed. Today, 150 years after Miescher's first ‘discovery' of DNA, we want to highlight his remarkable work.
Life Sciences - Jun 10
Life Sciences

Characterizing chromosome structure is fundamental to a better understanding of gene expression. Current experimental methods helped to build mechanistic models of chromosome folding, however they could not be formally validated so far by independent techniques.

Life Sciences - May 22
Life Sciences

From yeast to man, the genome is partitioned into subnuclear compartments, with active euchromatin spatially separated from silent heterochromatin, which is often found at the nuclear periphery.

Life Sciences - Apr 23
Life Sciences

Our actions are driven by “internal states” such as anxiety, stress or thirst - which will strongly affect and motivate our behaviors.

Life Sciences - Apr 8

Guillaume Diss joined the FMI as a new Quantitative Biology group leader on March 1. His research focuses on understanding the mechanisms whereby genetic variation translates into phenotypic variation - for example, in diseases.

Life Sciences - Mar 19
Life Sciences

Epigenetic memory of transcriptional gene silencing has been observed in several organisms. However, it was not known whether mechanisms exist that convey transgenerational memory of a silencing “experience”, without silencing the gene permanently.

Life Sciences - May 30
Life Sciences

UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by the DNA repair machinery, acting as a molecular sunscreen.

Health - Apr 25
Health

Intestinal organoids are three-dimensional structures derived from a single intestinal stem cell. They are great tools for applications ranging from fundamental biology to personalized and regenerative medicine.

Life Sciences - Apr 17
Life Sciences

Chromatin remodelers have the ability to move nucleosomes, which represent a physical barrier for access to DNA.

Life Sciences - Mar 25
Life Sciences

Puberty is a period of extensive changes of body morphology and function. As much as we are familiar with these life-altering changes, relatively little is known about what sets the whole process in motion.

Life Sciences - Mar 13

Five of our postdocs were recently awarded the prestigious EMBO and Maria Sklodowska-Curie Actions (MSCA) Fellowships. These grants are highly competitive and known worldwide for promoting innovative and interdisciplinary research.




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Medicine and Life Sciences