Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research
Friedrich Miescher Institute for Biomedical Research  
Discipline: Medicine/Pharmacology

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Life Sciences - Mar 19
Life Sciences
Epigenetic memory of transcriptional gene silencing has been observed in several organisms. However, it was not known whether mechanisms exist that convey transgenerational memory of a silencing “experience”, without silencing the gene permanently.
Life Sciences - Mar 13

Five of our postdocs were recently awarded the prestigious EMBO and Maria Sklodowska-Curie Actions (MSCA) Fellowships. These grants are highly competitive and known worldwide for promoting innovative and interdisciplinary research.

Life Sciences - Feb 26
Life Sciences

The heterochromatin of eukaryotes contains repetitive DNA, which can lead to genome instability when transcribed.

Life Sciences - Feb 5

Transcription of our genes mostly begins in regions of the genome called CpG islands. These are rich in the dinucleotide CpG (thus the name), critical for gene activity and devoid of DNA methylation.

Health - Jan 22

Botond Roska, who has a research group at the FMI and is co-director of the Institute of Ophthalmology Basel (IOB), is awarded the 2019 Louis-Jeantet Prize for Medicine, as announced yesterday. As one of the best-endowed awards in Europe, the Prize fosters scientific excellence and supports fundamental biological research that is of considerable significance for medicine.

Life Sciences - Jan 2

Our cutting-edge technology platforms are key enablers of research at the FMI. One of the biggest of these, with the largest number of users, is the Facility for Advanced Imaging and Microscopy (FAIM).

Careers - Mar 7

Susan Gasser, who has led the FMI for the past 15 years, has stepped down from her role as Director of the FMI, while she continues to lead her research team within the institute. Silvia Arber and Dirk Schübeler, FMI senior group leaders highly regarded for their scientific excellence and strong leadership skills, have been appointed co-directors of the FMI ad interim, from March 1st onwards.

Life Sciences - Feb 12
Life Sciences

The two ex-PhD students from the group of Georg Keller are recognized in the category "Neurosciences and Diseases of the Nervous System" for a study in which they shed light on neural circuits in the cortex that underlie the integration of movement and visual feedback.

Life Sciences - Jan 28

Two hallmarks of the integrated stress response of cells are the inhibition of translation and the formation of stress granules (SGs) and processing bodies (PBs). However, it is not well understood how both processes are coupled.

Life Sciences - Jan 14

Upon exit from self-renewal, embryonic cell stems differentiate into different types of tissues - a process regulated by various complex mechanisms. Recent work published by the Betschinger group shows the importance of the lysosome - which is directly associated with cellular metabolism and nutrition - in developmental progression.

Life Sciences - Dec 17, 2018
Life Sciences

For more than 100 years, biologists have known that cells contain various kinds of membraneless organelles and conjectured what organizing principles underlie them.

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Medicine and Life Sciences