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In today's medical landscape, antibiotics are pivotal in combatting bacterial infections. These potent compounds, produced by bacteria and fungi, act as natural defenses against microbial attacks. A team of researchers delved into the intricate world of glycopeptide antibiotics - a vital resource in countering drug-resistant pathogens - to uncover their evolutionary origins.

Slow waves that usually only occur in the brain during sleep are also present during wakefulness in people with epilepsy and may protect against increased brain excitability associated with the condition, finds a new study led by researchers at UCL.

Researchers at CHU Sainte-Justine find a way to use 3D printing to produce heart valves for eventual use in surgery on children with cardiac defects. In a breakthrough in pediatric cardiac science, Canadian researchers have successfully produced a bio-ink that could someday be used to print functional, durable heart valves, offering hope for improving the prognosis of children with heart defects.

MIT and MGH researchers design a local, gel-based drug-delivery platform that may provoke a system-wide immune response to metastatic tumors. For most metastatic cancer types, there are no reliably effective treatments. Therapies may slow the growth of tumors, but they will not eradicate them. Occasionally, however, treating a tumor in one location will cause untreated tumors elsewhere in the body to shrink or even regress completely - a dramatic but exceedingly rare phenomenon known as the abscopal effect.

Cruciate ligament injuries are among the most common injuries in sport. Researchers from the ZHAW and ZHdK have developed the ExerUp game in collaboration with a practice partner to help people return to their previous level of activity in addition to physiotherapy . A movement-based game is designed to support injured athletes after a cruciate ligament injury as part of physiotherapy and rehabilitation.

Researchers said very high levels of HDL-C linked to dementia risk in this study were uncommon and not diet related, but more likely to reflect a metabolic disorder. The findings may help doctors to recognise a group of older patients potentially at risk of dementia, particularly in those aged 75 and older.

Flavonoids & Co: Microorganisms in the human gut utilise so-called beta-elimination to break down plant natural products and thus make them available to humans. Fruit and vegetables contain a variety of plant natural products such as flavonoids, which give fruits their colour and are said to have health-promoting properties.

University of Waterloo researchers are pioneering a method to detect breast cancer in women early enough for them to receive life-saving treatment. The innovative technology will be cheaper and safer than common cancer diagnostic tools. The innovative technology aims to be more accurate as well as cheaper to provide than today's most common diagnostic tools such as X-ray mammography, ultrasound and magnetic resonance imaging (MRI).

One in 200 newborns is admitted to a neonatal unit with sepsis caused by a bacteria commonly carried by their mothers - much greater than the previous estimate, say Cambridge researchers. The team has developed an ultra-sensitive test capable of better detecting the bacteria, as it is missed in the vast majority of cases.

UCLA researchers detail how prostate cancers grow more aggressively to evade treatment Science + Technology UCLA researchers detail how prostate cancers grow more aggressively to evade treatment Key takeaways Some prostate cancers evolve into a rare, treatment-resitant tumor known as a small cell neuroendocrine, or SCN, cancer.

Insights that pave the way for novel therapeutic approaches to tackle cancer, fibrosis, and many age-related conditions have been uncovered by a team of scientists, including researchers from UCL. The research, published in Nature Cell Biology and led by the Laboratory of Medical Sciences (MRC-LMS), identifies a new target for a class of drugs that selectively eliminate cells that are known to provoke inflammation.

TUM researchers develop rapid test for severe infections Researchers have developed a method for assessing the number and structure of aggregated blood platelets (or thrombocytes) that can potentially help quantify the risk of a severe COVID-19 infection. As a result, they have identified a predictive biomarker for the seriousness of a COVID-19 infection.

A special gel with chemotherapy against peritoneal cancer, that is what start-up UPyTher is working on. The new technology could save many lives in the future. Each year, more than one million people worldwide contract peritoneal cancer. It is often the result of metastasis from colon, stomach, or ovarian cancer to the peritoneal cavity.

McGill researchers have made a breakthrough in diagnostic technology, inventing a 'lab on a chip' that can be 3D-printed in just 30 minutes. The chip has the potential to make on-the-spot testing widely accessible. As part of a recent study, the results of which were published in the journal  Advanced Materials, the McGill team developed capillaric chips that act as miniature laboratories.

Topics Western researchers have unveiled crucial insights into the sleep health of middle-aged and older adults in Canada, identifying social determinants that contribute to disparities in sleep satisfaction, efficiency, and duration. The study revealed that men report sleeping better than women, and contrary to previously held beliefs, sleep actually improves with age.

Heidelberg scientists unveil genetic programmes controlling the development of cellular diversity in the cerebellum of humans and other mammals The evolution of higher cognitive functions in human beings has so far mostly been linked to the expansion of the neocortex - a region of the brain that is responsible, inter alia, for conscious thought, movement and sensory perception.

Brain scans of former NFL players show lasting impact of collision sports New research from Johns Hopkins Medicine adds to a growing stack of evidence that collision sports including football, soccer, and boxing may lead to dementia and other forms of cognitive disorders Kristen Crocker / Published Nov 29, 2023 In a new study using brain scans of former NFL athletes, Johns Hopkins Medicine researchers say they found high levels of a repair protein present long after a traumatic brain injury such as a concussion takes place.

AI breakthrough may lead to highly personalized medicine in the treatment of serious diseases Machine learning is now helping researchers analyze the makeup of unfamiliar cells, which could lead to more personalized medicine in the treatment of cancer and other serious diseases. Researchers at the University of Waterloo developed GraphNovo, a new program that provides a more accurate understanding of the peptide sequences in cells.

Efficient removal of abnormal myelin allows survival of nerve fibers targeted by adaptive immune cells, according to a novel study by scientists of the University Hospital Würzburg. Myelin is an insulating sheath around axons - the processes connecting nerve cells - that is mostly composed of lipids and proteins.

Bonn researchers uncover contribution of Cylicin proteins to male fertility For successful fertilization, sperm should move forward rapidly and be shaped correctly. The unique structure of the sperm cells forms during spermiogenesis. Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit "Life & Health" at the University of Bonn have found that fertility problems in both mice and humans can be caused by loss of so-called cylicines.