Breakthrough allows researchers to watch molecules "wiggle"

A new crystallographic technique developed at the University of Leeds is set to transform scientists' ability to observe how molecules work. A research paper, published Methods, describes a new way of doing time-resolved crystallography, a method that researchers use to observe changes within the structure of molecules. Although fast time-resolved crystallography (Laue crystallography) has previously been possible, it has required advanced instrumentation that is only available at three sites worldwide. Only a handful of proteins have been studied using the traditional technique. The new method will allow researchers across the world to carry out dynamic crystallography and is likely to provide a major boost in areas of research that rely on understanding how molecules work, such as the development of novel smart materials or new drugs. Understanding how structure and dynamics are linked to function is key to designing better medicines that are targeted at specific states of molecules, helping to avoid unwanted side effects. “A time-resolved structure is a bit like having a movie for crystallographers,” said Professor Arwen Pearson, who led a team of researchers in the University's Faculty of Biological Sciences and School of Chemistry.