Early warning system for microbial invaders

Deadly viruses are first detected by our immune system by MDA5, a receptor that recognizes viral RNA soon after it infects the cell. Yale University researchers show that pairs of these molecules assemble along this viral RNA in long filaments, which scientists Yorgo Modis and Ian Berke propose trigger a partner signaling molecule, MAVS (seen in red), which in turn instructs the cell to mount an antiviral inflammatory response. Read the article
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