Consistency is the key to success in bread baking and biology

ANN ARBOR-Whether you're baking bread or building an organism, the key to success is consistently adding ingredients in the correct order and in the right amounts, according to a new genetic study by University of Michigan researchers. Using the baker's yeast Saccharomyces cerevisiae, Patricia Wittkopp and her colleagues developed a novel way to disentangle the effects of random genetic mutations and natural selection on the evolution of gene expression. Their findings are scheduled for online publication on March 16. "These results tell us that the effects of mutations available for natural selection to act on can play a large role in how an organism evolves. The approach we developed allows us to test what those influences are and to better understand how evolution works," said Wittkopp, an associate professor in the U-M Department of Ecology and Evolutionary Biology and in the Department of Molecular, Cellular and Developmental Biology. The first authors are EEB graduate student Brian Metzger and former MCDB graduate student David Yuan. In their study, the U-M researchers used the TDH3 gene, which helps baker's yeast cells convert sugar into energy used for growth.