Have crystals grown, or not? Tobias Mühlethaler checks his protein solutions in the crystal production facility at PSI. (Photo: Paul Scherrer Institute/Mahir Dzambegovic)
Have crystals grown, or not? Tobias Mühlethaler checks his protein solutions in the crystal production facility at PSI. (Photo: Paul Scherrer Institute/Mahir Dzambegovic) - Researchers at the Paul Scherrer Institute PSI and the Italian Institute of Technology IIT have developed a novel substance that disables a protein in the cell skeleton, leading to cell death. In this way, substances of this type can prevent, for example, the growth of tumours. To accomplish this, the researchers combined a structural biological method with the computational design of active agents. The study appeared in the journal Angewandte Chemie International Edition . The cell skeleton, also called the cytoskeleton, pervades all of our cells as a dynamic network of thread-like protein structures. It gives cells their form, aids in the transport of proteins and larger cell components, and plays a crucial role in cell division.
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