Mass spectrometry-based draft of the mouse proteome

A scientist at the Chair of Proteomics and Bioanalytics working at the mass spectrometer. Image: B. Küster / TUM - Proteins control and organize almost every aspect of life. The totality of all proteins in a living organism, a tissue or a cell is called the proteome. Using mass spectrometry, researchers at the TUM School of Life Sciences characterize the proteome, or protein complement of the genome, in important model organisms. In 2014, a team at the Chair of Proteomics and Bioanalytics reported a draft human proteome for the first time, followed by that of the model plant Arabidopsis thaliana in 2020, and now that of the most common laboratory mouse. The laboratory mouse ranks among the most important experimental systems for biomedical research and molecular reference maps of such models are essential informational tools. "We present a quantitative draft of the mouse proteome and phosphoproteome constructed from 41 healthy tissues.