The top image shows the forces generated by an external magnetic field on particles embedded in the material. These interactions are simulated by a computational model that is able to guide the manufacturing and experimental process (middle image). Finally, the generated forces are transmitted to the cells cultured on the smart material (bottom image). This action on the cells will lead to changes or activation of their biological functions, such as proliferation, migration or orientation, among others.
The top image shows the forces generated by an external magnetic field on particles embedded in the material. These interactions are simulated by a computational model that is able to guide the manufacturing and experimental process ( middle image ). Finally, the generated forces are transmitted to the cells cultured on the smart material ( bottom image ). This action on the cells will lead to changes or activation of their biological functions, such as proliferation, migration or orientation, among others. Scientists from 4D-BIOMAP, an ERC research project at the Universidad Carlos III de Madrid (UC3M), have developed a new experimental method, based on magneto-active polymers, to study cellular behaviour. These compounds, which consist of a polymeric matrix (e.g., an elastomer) containing magnetic particles (e.g., iron), mechanically react by changing their shape and stiffness. This system could be used to study complex scenarios (such as brain trauma, wound healing, etc.) or to influence cellular responses, guiding their functions.
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