The photoswitching rates of fluorescent dyes are as unique as a fingerprint and as readable as a barcode.
The photoswitching rates of fluorescent dyes are as unique as a fingerprint and as readable as a barcode. Researchers at the University of Würzburg develop the "photoswitching fingerprint analysis". A unique technology that for the first time allows the analysis of molecular processes and revolutionises biomedical research. Super-resolution microscopy allows fluorescence images of cells, organelles and molecular complexes to be acquired with unprecedented spatial resolution. However, this resolution is not sufficient to resolve proteins as small as a few nanometers and their interactions with other molecules or the architecture of protein complexes. It prevents, for example, the study of the molecular interplay of neurons in learning and memory processes. Overcoming dynamic resolution limits .
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