The series of folding steps represents successive reactions. Starting from the simple cyclobutanol starting material (’piece of paper’), an isolable intermediate compound can be produced (’origami hat’). By adding a Brønsted acid activator, an intramolecular cyclisation is triggered, which leads to high value-added tetralin derivatives (’origami boat’). Alternatively, so-called nucleophiles can be introduced by activating the benzylic carbon-fluorine bond (’origami heart’).
"Molecular origami" creates new structures in a single operation / Team from the University of Münster presents study in "Nature Communications". The series of folding steps represents successive reactions. Starting from the simple cyclobutanol starting material ('piece of paper'), an isolable intermediate compound can be produced ('origami hat'). By adding a Brønsted acid activator, an intramolecular cyclisation is triggered, which leads to high value-added tetralin derivatives ('origami boat'). Alternatively, so-called nucleophiles can be introduced by activating the benzylic carbon-fluorine bond ('origami heart'). Münster University - Gilmour Group Fluorine is found rarely in naturally occurring organic molecules. However, this chemical element is indispensable for the production of pharmaceuticals or agrochemicals.
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