news

In the ICARUS-BREAST 01 study, more than half of patients with metastatic breast cancer experienced a reduction or complete disappearance of their disease thanks to treatment, and in some patients, this response has now lasted for more than two years. Dr Barbara Pistilli, Head of the Breast Pathology Committee at Gustave Roussy, and Guillaume Montagnac, an Inserm researcher in the "Tumor Cell Dynamics" unit he heads at Gustave Roussy, are please

In people living with obesity, visceral adipose tissue - located deep around the organs - can become fibrous and rigid. This phenomenon, known as fibrosis , disrupts normal fat function and contributes to metabolic complications such as insulin resistance and type 2 diabetes. A team of researchers from Sorbonne University, Inserm and AP-HP, working in the Nutriomics laboratory, has identified a new therapeutic strategy to counter the effects of fibrosis.

What if the study of bacteria could illuminate our understanding of human immunity? In recent years, scientists have been exploring unexpected links between human proteins involved in the body's defense mechanisms and certain bacterial immune proteins. Focusing on conserved immune domains originating from bacteria, termed "ancestral immune", a team of researchers from Institut Curie, Institut Pasteur, and Inserm identified a novel human immune protein, SIRal.

A team from the Institut Curie, Inserm and CNRS has uncovered a hitherto unknown molecular mechanism linking estrogens (female sex hormones) to the aggravation of certain cancers not traditionally considered hormone-dependent, such as melanoma, gastric cancer and thyroid cancer.minine sex hormones) to the aggravation of certain cancers not traditionally considered hormone-dependent, such as melanoma, gastric cancer and thyroid cancer.

Characteristic depressive episodes are the most common mental disorders worldwide. One in five people will suffer from depression in their lifetime, with suicidal risk responsible for several thousand deaths a year in France.

Human fibroblasts observed by fluorescence microscopy. Mitochondria are marked in red, fibroblast core DNA is marked in blue © Nivea Dias Amoedo/Inserm A deterioration in skin quality, its ability to heal, and its normal aging, is often observed in people with chronic hyperglycemia. A team of researchers from Inserm, the University of Bordeaux and LVMH Recherche has investigated how hyperglycemia alters the human dermis, and in particular the cells involved in its healing, the fibroblasts.

While glioblastoma is a highly aggressive brain tumor that currently offers little hope of cure, researchers at the CANTHER laboratory (CNRS / Inserm / University of Lille / Lille University Hospital / Pasteur Institute of Lille) and the Laboratoire de Bioimagerie et Pathologies (CNRS / University of Strasbourg) have succeeded in identifying different forms of this tumor and mapping them precisely by analyzing the activity of gene regulatory factors.

Food additive mixtures are an everyday feature of our diets, especially through ultra-processed foods. Until recently, safety evaluations of these additives have been conducted substance by substance due to a lack of data on the effect of them ingested together. In a new study, researchers from Inserm, INRAE, Sorbonne Paris Nord University, Paris Cité University and Cnam, as part of the Nutritional Epidemiology Research Team (CRESS-EREN), examined the possible links between exposure to mixtures of commonly consumed food additives and the onset of type 2 diabetes.

Many cases of sudden cardiac death could be avoided thanks to artificial intelligence. As part of a new study to be published in European Heart Journal, a network of artificial neurons imitating the human brain was developed by researchers from Inserm, Paris Cité University and the Paris public hospitals group (AP-HP), in collaboration with their colleagues in the USA.

Mouse macrophages visualized using confocal microscopy, showing the nuclei (blue) and the actin network (orange). Mónica Fernández Monreal, Bordeaux Imaging Center Macrophages, key cells of the immune system, play a central role in cleaning the body by ingesting and destroying pathogens (bacteria, viruses, etc.) and damaged cells.

Motoneurones (stained by immunohistochemistry for ChAT) of the lumbar section of the spinal cord in ALS mouse models. Scale 100 mm © Simon J Guillot, Daniel Beckett ,Matei Bolborea Amyotrophic Lateral Sclerosis (ALS), Charcot's disease, or Lou Gehrig's disease is a severe neurodegenerative disease that leads to progressive paralysis of muscles involved in voluntary movement.

The Remember project provides new insights into post-traumatic stress disorder © Inserm Following a shocking, dangerous or frightening experience, such as a terrorist attack, many people develop post-traumatic stress disorder (PTSD). In order to improve its management, numerous scientific studies are examining the neurobiological processes underlying the development of this disorder.

MASH is a growing pandemic worldwide, with obesity and diabetes on the rise. It is also an area of significant unmet medical need. François Pattou Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease (NAFLD), impacts roughly 30% of the global adult population.

With the rise of antibiotics in the 1930s, phage therapy (i.e. the use of viruses called bacteriophages to fight bacterial infections) was abandoned. Today, with the rise of antibiotic resistance making the treatment of bacterial infections increasingly difficult, phage therapy is once again attracting the interest of doctors and researchers, despite the complexity of its application due to the great diversity and specificity of bacteriophages.

The higher we climb, the lower the oxygen supply to our bodies. Since 2019, a research team from Inserm, Grenoble Alpes University and Grenoble Alpes University Hospital has been investigating the health consequences of oxygen restriction. Their work has taken them to Peru, to Rinconada, the world's highest city (5,300 m), which has become a veritable open-air laboratory.

Unsplash Teams from the departments of clinical and biological hematology, obstetrics and gynecology, pharmacovigilance, medical intensive care, infectiology, as well as the clinical research unit of theHôpital Cochin-Port Royal AP-HP, Université Paris Cité, Inserm and the HEMAPREG network, coordinated by Mr Pierre Pinson and Drs Ismael Boussaid and Rudy Birsen, have conducted a study on pregnancy-associated hematological cancers.

Myotubular myopathy is a rare genetic disease caused by mutations in the MTM1 gene. A study carried out in animals by researchers from Inserm, CNRS and the University of Strasbourg at the IGBMC, in collaboration with American teams, has shed light on the underlying mechanisms of this disease. Published in the journal Science , these studies suggest that vitamin K supplementation could improve certain symptoms of the disease, opening up new therapeutic prospects.

Central Africa, especially the Democratic Republic of the Congo (DRC), is highly affected by successive mpox outbreaks. Until now, the extent of genetic diversity of the virus had not been well characterised in this region of the world. For the first time, as part of the AFROSCREEN project and the PANAFPOX project , teams from the Institut National de Recherche Biomédicale (INRB) in DRC, IRD and Inserm have provided important new information on the genetic diversity of mpox virus circulating in DRC and on the predominant route of transmission.

Nirsevimab is an antibody targeting the respiratory syncytial virus (RSV). Available in France since September 2023, it is indicated in neonates and infants for the prevention of bronchiolitis caused by RSV. AdobeStock Nirsevimab is an antibody targeting the respiratory syncytial virus (RSV). Available in France since September 2023, it is indicated in neonates and infants for the prevention of bronchiolitis caused by RSV.

L'alimentation serait responsable d'environ 30% des décès dus aux maladies cardiovasculaires. Cardiovascular diseases are the leading cause of mortality in Western Europe, accounting for 1/3 of deaths in 2019. Diet is thought to be responsible for around 30% of such deaths. Nutrition-related prevention policies therefore constitute a major public health challenge for these diseases.