How can bats harbor so many viruses without developing symptoms?

Publication of the CIRI in the journal Science Advances on November 23, 2022. CNRS press alert on November 23, 2022. Bats are asymptomatic carriers of a multitude of viruses that are pathogenic to most other mammals. How has their immune system evolved to shield them from these pathogens? A team of scientists-the majority affiliated with the CNRS, Claude Bernard Lyon 1 University, and ENS de Lyon -has just published an article in Science Advances addressing that question. Part of the explanation may lie in the number of copies and diversification of the gene encoding the PKR enzyme, which is involved in the immune response to viruses. While most mammals possess a single copy of this gene, some bats have several copies, allowing them to diversify their antiviral repertoire and thus defend themselves from a wide range of viruses. This has been made possible in bats by the accumulation of multiple copies of the PKR gene, each subjected to positive selection during the evolution of these animals (Positive selection is the evolutionary acquisition by species of genetic mutations that increase their chances of reproducing.