Fluorescence microscopy images of blood vessels supported by perivascular cells. The top row shows vessels with perivascular cells from normal lung tissue compared to vessels supported by tumor-derived perivascular cells (bottom row). The vessels on the bottom show a higher leakage.
Media releases, information for representatives of the media Media Relations (E) A study from Bern University Hospital in collaboration with the University of Bern shows that so-called perivascular-like cells from lung tumors behave abnormally. They not only inadequately support vascular structures, but also may actively modulate the inflammatory and immune response. These findings may represent a novel stromal cancer target. Lung cancer accounts for the highest number of cancer-related deaths, with an estimated 1.6 million deaths in 2012 worldwide. Among different types of lung cancer, non-small cell lung cancer (NSCLC) is the most prevalent. Recent advances in genetic analyses led to targeted treatments that work very effectively in cases where tumors carry a specific targetable mutation. Another promising strategy focuses on redirecting the immune response to recognize and attack tumor cells.
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