Steroid hormone metabolites activate the pyrin inflammasome

Publication of the CIRI in the journal Cell Reports on October 11, 2022. CNRS-INSB communication on November 7, 2022. The pyrin inflammasome is an immune complex known for its importance in antibacterial responses. The study published in the journal Cell Reports changes this paradigm by showing that pyrin is activated by derivatives of the sex hormones progesterone and testosterone, endogenous molecules produced in our body, without association with a bacterial infection. The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune defenses against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet, the second step is still poorly understood.
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