S Pierre Gönczy, Douglas Hanahan, and Tobias J. Kippenberg (credit: Alain Herzog/EPFL)
Professors Pierre Gönczy and Douglas Hanahan (School of Life Sciences), and Professor Tobias J. Kippenberg (School of Basic Sciences/School of Engineering) have been awarded ERC Advanced Grants. The ERC Advanced Grants are given each year to established, leading principal investigators to fund long-term funding for "ground-breaking, high-risk" research projects in any field. This year, the ERC has awarded an Advanced Grant to three EPFL professors. Pierre Gönczy (School of Life Sciences/ISREC) CENGIN: "Deciphering and engineering centriole assembly" Deciphering and engineering the assembly of cellular organelles is a fundamental pursuit in biology. The centriole is an evolutionarily conserved organelle that is critical for countless cellular processes, including signaling, motility and division. Centrioles exhibit a striking architecture that stems in part from the self-assembling properties of a set of evolutionarily conserved proteins identified in the last decade. The CENGIN project will tackle two important challenges ahead of the field: develop assays to probe the dynamics of centriole assembly with molecular precision and engineer building blocks towards assembling synthetic centrioles. This will help reveal and modulate the mechanisms by which these proteins together build a functional organelle. Douglas Hanahan (School of Life Sciences/ISREC)
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