The diagram shows how resolution-inducing lipid mediators ?switch on? healing macrophages. Macrophages are depicted (CD68 red, CD206 green) in the atherosclerotic lesion after administration of Resolvin D2 and Maresin 1. (Illustration: O. Söhnlein, LMU)
Atherosclerosis - commonly known as "hardening of the arteries" - occurs when deposits on the inner walls of vessels lead to chronic inflammation and narrowing of the vessels. That can restrict blood flow or block it entirely, ultimately triggering a cardiac infarction or a stroke. Treatment strategies up to now focus primarily on inhibiting the inflammation reaction. Researchers led by Professor Oliver Söhnlein from the Institute for Cardiovascular Prevention at LMU have now developed a completely new treatment strategy which focuses on stimulating the body's own healing processes. Active substances contained in fish oil and other sources play a key role in this, improving atherosclerosis in mice tested. The scientists reported their results in the professional journal Circulation Research. In recent years, research results have shown that not only the occurrence, but also the resolution of inflammations is an active process of the immune defense system.
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