Illustration of the concept using 3D fluorescence images as biological templates for cell migration simulations. Red: vessels, green: megacaryocytes, dark blue: Hemapoietic stem cells, cyan: Neutrophils. Scale bar: 100 µm. (Image: Rudolf-Virchow-Zentrum / Universität Würzburg)
07/19/2019 - Würzburg Scientists found that megakaryocytes act as "bouncers" and thus modulate bone marrow niche properties and cell migration dynamics. The study was published in the Journal "Haematologica". Hematopoiesis is the process of forming blood cells, which occurs predominantly in the bone marrow. The bone marrow produces all types of blood cells: red blood cells, platelets, and white blood cells (leucocytes). One of the most prominent white blood cell types are neutrophils - they help the body fight against infections and are the most abundant subpopulation of leukocytes. They are short-lived and highly mobile, and can enter parts of tissue where other cells/molecules cannot. All hematopoietic cells that develop in the bone marrow must cross the blood vessel wall to enter the circulation system.
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