Chemists develop new synthesis method for producing fluorinated piperidines

Pressure vessel (autoclave) for the hydrogenation of fluorinated pyridines. The
Pressure vessel (autoclave) for the hydrogenation of fluorinated pyridines. The reactions are carried out at a hydrogen pressure of 50 bar (normal atmospheric pressure is 1 bar). © Frank Glorius
Synthetic molecules are essential for many products in our lives: medicines, crop protection agents or special materials such as Teflon. These molecules have several components, which can be combined in a variety of ways, resulting in different properties. Both so-called piperidines and fluorinated groups are particularly important. Piperidines are small, ring-shaped chemical compounds. Since, as a result of their particular properties, fluorine atoms bring about dramatic changes in the properties of certain products -they are often integrated in pharmaceuticals. Hence around twenty percent of all medicines sold worldwide contain fluorine. Up to now, however, combining fluorine atoms and piperidines has always been an extremely laborious process.
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