Moritz Niemann and André Schneider, Department of Chemistry and Biochemistry (DCB), University of Bern.
The complexity of molecular structures in the cell is amazing. Having achieved great success in elucidating these structures in recent years, biologists are now taking on the next challenge: to find out more about how they are constructed. A joint research project between two groups from the University of Bern and ETH Zurich now provides insight into a very unusual construction process in the unicellular parasite Trypanosoma brucei. Cells consist of a multitude of molecular structures, some of them exhibiting a staggering complexity. Ribosomes, the protein factories of the cell, belong to the biggest and most sophisticated complexes and are made up of RNA as well as a large number of proteins. They exist in every living being and are considered as one of the cellular machines that has changed the least through all stages of the evolution. But there are exceptions: In mitochondria, cellular organelles that serve as power plants, ribosomes look considerably different.
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