Tumor stem cells from prostate cancer. The coloring with different fluorochromes highlights the extensive network of mitochondria (red/green) surrounding the cell nuclei (blue).
Tumor stem cells from prostate cancer. The coloring with different fluorochromes highlights the extensive network of mitochondria (red/green) surrounding the cell nuclei (blue). A study by investigators at the Institute of Oncology Research (IOR, affiliated to USI Universitą della Svizzera italiana) reveals a new way to eliminate cancer stem cells (CSC) in prostate tumours and enhance treatment efficacy. The study is published in the scientific journal Cell Metabolism. Prostate cancer is a leading cause of death in developed countries. After initial response to hormonal therapies, many patients develop highly aggressive, hormone-refractory tumours for which there are currently limited therapeutic options. Investigators at the Institute of Oncology Research in Bellinzona, directed by Prof. Carlo V. Catapano, have uncovered a novel mechanism that promotes expansion of CSCs in prostate cancer by controlling mitochondrial division and showed that blocking this process leads to the progressive loss of CSCs and has a dramatic impact on tumour growth in multiple prostate cancer models.
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